Jeffrey Alan Hubbell

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Recently, functionalized superparamagnetic iron oxide nanoparticles (SPIONs) have been utilized for protein separation and therapeutic delivery of DNA and drugs. The development of new methods and tools for the targeting and identification of specific biom ...

Type 1 diabetes is an autoimmune disease marked by the destruction of insulin-producing beta cells in the pancreatic islets. Strategies to delay onset or prevent the autoimmune recognition of beta cell antigens or T cell-mediated killing of beta cells have ...

The present invention relates to polymeric structures, in the form of flat membrane-like surfaces or micro- nanostructures such as capsules, characterized in that it comprises a substantially two-dimensional layer of covalently-bonded monomers of R-substit ...

Ligands that specifically bind to articular cartilage tissues are disclosed, including uses for targeting therapeutics towards articular cartilage tissue and new materials for articular cartilage. The ligands are effective in vivo to target therapeutic mat ...

The application describes ligands for binding targets, the ligands preferably including peptides having at least one sulfated or sulfonated amino acid. The ligand preferably specifically binds to heparin binding sites of biomolecules. Compositions, systems ...

A major challenge for therapeutic delivery of angiogenic agents such as vascular endothelial growth factor (VEGF) is to achieve sustained, low dose signaling leading to durable neovessel formation. To this end, we recently created a variant of VEGF(121), T ...

We present new polymeric amphiphiles derived from N-acryloyl derivatives of the cyclic secondary amines: morpholine, piperidine, and azocane polymerized by reversible addition -fragmentation transfer (RAFT) polymerization. Both homopolymerization and block ...

By binding growth factors (GFs), the ECM tightly regulates their activity. We recently reported that the heparin-binding domain II of fibronectin acts as a promiscuous high-affinity GF-binding domain. Here we hypothesized that fibrin, the provisional ECM d ...

Growth factors are very promising molecules to enhance bone regeneration. However, their translation to clinical use has been seriously limited, facing issues related to safety and cost-effectiveness. These problems derive from the vastly supra-physiologic ...

Photocatalytic lithography (PCL) is an inexpensive, fast, and robust method of oxidizing surface chemical moieties to produce patterned substrates. This technique has utility in basic biological research as well as various biochip applications. We report o ...

To investigate the migration response of cells to changes in their biophysical environment, a novel uniaxial cell stimulation device (UCSD) has been designed and tested. The device is capable of applying very precise user-defined static or dynamic mechanic ...

Nanoarray fabrication is a multidisciplinary endeavor encompassing materials science, chemical engineering, and biology. We formed nanoarrays via a new technique, porphyrin-based photocatalytic nanolithography. The nanoarrays, with controlled features as s ...

Antigen targeting and adjuvancy schemes that respectively facilitate delivery of antigen to dendritic cells and elicit their activation have been explored in vaccine development. Here we investigate whether nanoparticles can be used as a vaccine platform b ...

The extracellular matrix of dense, avascular tissues presents a barrier to entry for polymer-based therapeutics, such as drugs encapsulated within polymeric particles. Here, we present an approach by which polymer nanoparticles, suffciently small to enter ...

Protein therapeutics represent a powerful class of clinically approved drugs for the prevention and treatment of various diseases. Once administered, the biological fate of protein therapeutics is governed by the body's various complex biochemical and biop ...

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat acute pain, fever, and inflammation and are being explored in a new indication in cancer. Side effects associated with long-term use of NSAIDs such as gastrointestinal damage and elevat ...

Poly(ethylene glycol)-stabilized poly(propylene sulfide) core (PEG-PPS) nanoparticles (NPs) smaller than 50 nm efficiently travel to draining lymph nodes and interact with antigen-presenting cells (APCs) to induce potent immune responses following intrader ...

Tissue-engineered grafts for the urinary tract are being investigated for the potential treatment of several urologic diseases. These grafts, predominantly tubular-shaped, usually require in vitro culture prior to implantation to allow cell engraftment on ...

The main problem associated with the administration of anti-cancer medication is that the drug is delivered throughout the body causing undesirable side effects. Therefore, it is important to synthesize drug carriers capable of minimizing the adverse side ...

Fibrin plays an important role in wound healing and regeneration, and enjoys widespread use in surgery and tissue engineering. The enzymatic activity of Factor XIIIa was employed to covalently incorporate exogenous bioactive peptides within fibrin during c ...

Jeffrey Alan Hubbell

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Superparamagnetic Nanoparticles as a Powerful Systems Biology. Characterization Tool in the Physiological Context

Bioengineering strategies for inducing tolerance in autoimmune diabetes

Two-dimensional polymeric structures and method for producing thereof

Polypeptide ligands for targeting cartilage and methods of use thereof

Compositions and methods for use of bioactive agents derived from sulfated and sulfonated amino acids

The role of actively released fibrin-conjugated VEGF for VEGF receptor 2 gene activation and the enhancement of angiogenesis

RAFT homo- and copolymerization of N-acryloyl-morpholine, piperidine, and azocane and their self-assembled structures

Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix

Extracellular matrix-inspired growth factor delivery systems for bone regeneration

Phototocatalytic Lithography of Poly(propylene sulfide) Block Copolymers: Toward High-Throughput Nanolithography for Biomolecular Arraying Applications

Part I: A novel in-vitro system for simultaneous mechanical stimulation and time-lapse microscopy in 3D

Porphyrin-based Photocatalytic Nanolithography A NEW FABRICATION TOOL FOR PROTEIN ARRAYS

Exploiting lymphatic transport and complement activation in nanoparticle vaccines

Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage

Drug development: longer-lived proteins

Preparation of Well-Defined Ibuprofen Prodrug Micelles by RAFT Polymerization

Polymer micelles with pyridyl disulfide-coupled antigen travel through lymphatics and show enhanced cellular responses following immunization

High-density collagen gel tubes as a matrix for primary human bladder smooth muscle cells

Investigating the acoustic release of doxorubicin from targeted micelles

Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension