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Jeffrey Alan Hubbell

Cette personne n’est plus à l’EPFL

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Publications associées (229)

Analytical ultracentrifugation to support the development of biomaterials and biomedical devices

Jutta Christine Wandrey, Jeffrey Alan Hubbell, Conlin O'Neil, Urara Hasegawa

Analytical ultracentrifugation (AUC) primarily serves to investigate hydrodynamic and thermodynamic properties of natural and synthetic macromolecules and colloids in solution, dispersion or suspension. Beside such more conventional use, AUC can support ma ...

2011

Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing

Mikaël Martino, Jeffrey Alan Hubbell, Mayumi Mochizuki Martino, Federico Tortelli

Although growth factors naturally exert their morphogenetic influences within the context of the extracellular matrix microenvironment, the interactions among growth factors, their receptors, and other extracellular matrix components are typically ignored ...

2011

Enzymatic- and temperature-sensitive controlled release of ultrasmall superparamagnetic iron oxides (USPIOs) (vol 9, pg 7, 2011)

Jeffrey Alan Hubbell, Conlin O'Neil

2011

Nanoparticle conjugation of antigen enhances cytotoxic T-cell responses in pulmonary vaccination

Jeffrey Alan Hubbell, Melody Swartz, Marie Ballester, Armando Stano, Karen Dane, Benjamin John Marsland

The ability of vaccines to induce memory cytotoxic T-cell responses in the lung is crucial in stemming and treating pulmonary diseases caused by viruses and bacteria. However, most approaches to subunit vaccines produce primarily humoral and only to a less ...

National Academy of Sciences2011

Engineered aprotinin for improved stability of fibrin biomaterials

Jeffrey Alan Hubbell, Peter Frey, Stephane Kontos, Kristen Lorentz

Fibrin has been long used clinically for hemostasis and sealing, yet extension of use in other applications has been limited due to its relatively rapid resorption in vivo, even with addition of aprotinin or other protease inhibitors. We report an engineer ...

2011

Biocompatible dispersions of carbon nanotubes: a potential tool for intracellular transport of anticancer drugs

Jeffrey Alan Hubbell

The use of the biocompatible amphiphilic diblock copolymer poly(ethylene glycol-b-propylene sulfide) (PEG(44)PPS(20)) allows a tuned loading of doxorubicin onto the surface of non-functionalized multi-walled carbon nanotubes and an efficient cell internali ...

Royal Society of Chemistry2011

Nano-sized drug-loaded micelles deliver payload to lymph node immune cells and prolong allograft survival

Jeffrey Alan Hubbell, Melody Swartz, Conlin O'Neil, Alice Anna Tomei, Jackson Eby, Karen Dane

By delivering immunomodulatory drugs in vivo directly to lymph nodes draining an injection site, an opportunity exists to increase drug bioavailability to local immune cells. Importantly, particles smaller than 100 nm are efficiently transported through ly ...

Elsevier2011

Assessing the Role of Poly(ethylehe glycol-bl-propylene sulfide) (PEG-PPS) Block Copolymers in the Preparation of Carbon Nanotube Biocompatible Dispersions

Jeffrey Alan Hubbell, Conlin O'Neil, Davide Demurtas

Amphiphilic block copolymers based on hydrophobic polysulfides (poly(propylene sulfide), PPS) and hydrophilic polyethers (poly(ethylene glycol), PEG) have been used to solubilize and disperse single-walled carbon nanotubes (SWNTs). The obtained highly conc ...

American Chemical Society2010

Dynamic Perspective on the Function of Thermoresponsive Nanopores from in Situ AFM and ATIZ-IR Investigations

Jeffrey Alan Hubbell, Harry Heinzelmann, Ana Maria Popa

This article describes the morphological and chemical characterization of stimuli-responsive functionalized silicon surfaces provided in parallel by atomic force spectroscopy (A FM) and Fourier transform infrared spectroscopy (FT-IR) enhanced by the single ...

2010

Nanoparticles for immunotherapy

Jeffrey Alan Hubbell, Melody Swartz, Conlin O'Neil, Sai Reddy, Eleonora Simeoni

Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. ...

2010

Biomimetic materials in tissue engineering

Mikaël Martino, Jeffrey Alan Hubbell, Jennifer Patterson

Biomaterial matrices are being developed that mimic the key characteristics of the extracellular matrix, including presenting adhesion sites and displaying growth factors in the context of a viscoelastic hydrogel. This review focuses on two classes of mate ...

Elsevier2010

DRUG DEVELOPMENT Longer-lived proteins

Jeffrey Alan Hubbell

2010

Controlled release nanoparticle-embedded coatings reduce the tissue reaction to neuroprostheses

Philippe Renaud, Jeffrey Alan Hubbell, André Mercanzini, Philippe Colin, Jean-Charles Bensadoun, Sai Reddy

Controlled release coatings were developed for neuroprostheses with the aim of combating the tissue reaction following implantation in the brain. The coatings consist of poly(propylene sulfide) drug-eluting nanoparticles embedded in a poly(ethylene oxide) ...

Elsevier2010

The effect of matrix characteristics on fibroblast proliferation in 3D gels

Matthias Lütolf, Jeffrey Alan Hubbell, Martin Ehrbar, Simone Rizzi

Engineering synthetic hydrogels on a molecular basis to introduce natural features that are important in instructing cell behavior is becoming increasingly crucial in biomaterial-based approaches for regenerative medicine and in cell biology to study cell– ...

Elsevier2010

A facile strategy for the modification of polyethylene substrates with non-fouling, bioactive poly(poly(ethylene glycol) methacrylate) brushes

Jeffrey Alan Hubbell, Harm-Anton Klok, Brian Pullin

This manuscript reports a facile strategy for the modification of polyethylene, a widely used biomaterial, with a thin non-biofouling coating that can act as a platform to introduce biochemical cues to control and direct, e.g., cell adhesion and proliferat ...

Wiley-Blackwell2010

Synthesis of Pyridyl Disulfide-Functionalized Nanoparticles for Conjugating Thiol-Containing Small Molecules, Peptides, and Proteins

Jeffrey Alan Hubbell, Conlin O'Neil, Urara Hasegawa

Previously we reported emulsion polymerization of propylene sulfide with Pluronic F127 as an emulsifier, yielding nanoparticles (NPs) in the 25 nm size range. Immunologically functional NPs were prepared by adding an antigen Pluronic conjugate to the polym ...

2010

In vitro uptake of amphiphilic, hydrogel nanoparticles by J774A.1 cells

Jeffrey Alan Hubbell

We here report improved synthesis and in vitro interactions of amphiphilic hydrogel nanoparticles with the macrophage cell line J774A.1. Nanoparticles comprising dispersed hydrophobic nanodomains of poly(propylene glycol) within a continuous phase of hydro ...

2010

Engineering integrin signaling for promoting embryonic stem cell self-renewal in a precisely defined niche

Jeffrey Alan Hubbell, Jong Eun Ihm, Yun Suk Jo, Mayumi Mochizuki Martino, Stephane Kontos, Seung Tae Lee, Jungim Yun

We present development and use of a 3D synthetic extracellular matrix (ECM) analog with integrin- specific adhesion ligands to characterize the microenvironmental influences in embryonic stem cell (ESC) self-renewal. Transcriptional analysis of 24 integrin ...

Elsevier2010

Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2

Jeffrey Alan Hubbell, Jennifer Patterson

Bioactive hydrogels formed by Michael-type addition reactions of end-functionalized poly(ethylene glycol) macromers with cysteine-containing peptides have been described as extracellular matrix mimetics and tissue engineering scaffolds. Although these mate ...

Elsevier2010

Block copolymers and uses thereof

Jeffrey Alan Hubbell, Melody Swartz, Conlin O'Neil

An encoding/decoding apparatus and method using a low-density parity-check code (LDPC code) is disclosed. Basic column group information, serving as a set of information regarding positions of rows with weight 1, is extracted from a reference column in eac ...

2010

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