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Jeffrey Alan Hubbell

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Publications associées (229)

Engineering antigens for in situ erythrocyte binding induces T-cell deletion

Jeffrey Alan Hubbell, Stephane Kontos, Iraklis Kourtis, Karen Dane

Antigens derived from apoptotic cell debris can drive clonal T-cell deletion or anergy, and antigens chemically coupled ex vivo to apoptotic cell surfaces have been shown correspondingly to induce tolerance on infusion. Reasoning that a large number of ery ...

Natl Acad Sciences2013

Proteolytic Processing Regulates Placental Growth Factor Activities

Jeffrey Alan Hubbell, Stéphanie Elisabeth Metzger, Martin Ehrbar, Manuel Koch

Placental growth factor (PlGF) is a critical mediator of blood vessel formation, yet mechanisms of its action and regulation are incompletely understood. Here we demonstrate that proteolytic processing regulates the biological activity of PlGF. Specificall ...

Amer Soc Biochemistry Molecular Biology Inc2013

Proangiogenic Hydrogels Within Macroporous Scaffolds Enhance Islet Engraftment in an Extrahepatic Site

Mikaël Martino, Jeffrey Alan Hubbell

The transplantation of allogeneic islets in recent clinical trials has shown substantial promise as a therapy for type 1 diabetes; however, long-term insulin independence remains inadequate. This has been largely attributed to the current intravascular, he ...

Mary Ann Liebert, Inc2013

Erythrocyte-binding therapeutics

Jeffrey Alan Hubbell, Stephane Kontos, Karen Dane

Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared a ...

2013

Translating materials design to the clinic

Jeffrey Alan Hubbell

Nature Publishing Group2013

Vesicle Photonics

Jeffrey Alan Hubbell, Demetri Psaltis, Andreas Vasdekis, Sylvie Roke

Amphiphiles, under appropriate conditions, can self-assemble into nanoscale thin membrane vessels (vesicles) that encapsulate and hence protect and transportmolecular payloads.Vesicles assemble naturally within cells but can also be artificially synthesize ...

Annual Reviews2013

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A(165)

Mikaël Martino, Jeffrey Alan Hubbell, Melody Swartz

Synergy in the downstream signaling pathways of the vascular endothelial growth factor receptor-2 (VEGFR-2) and the integrin alpha v beta 3 is critical for blood vessel formation. Thus, agents that activate both receptors could possess efficient pro-angiog ...

Elsevier2013

Tenascin C Promiscuously Binds Growth Factors via Its Fifth Fibronectin Type III-Like Domain

Jeffrey Alan Hubbell, Jeffrey James Rice, Federico Tortelli

Tenascin C (TNC) is an extracellular matrix protein that is upregulated during development as well as tissue remodeling. TNC is comprised of multiple independent folding domains, including 15 fibronectin type III-like (TNCIII) domains. The fifth TNCIII dom ...

Public Library of Science2013

Methode pour la preparation des copolymeres blocs pour systemes auto-assembles multifonctionnels

Nicola Tirelli, Jeffrey Alan Hubbell

The invention provides methods for the preparation of multiblock copolymers, dispersions of multiblock copolymers, vesicles and micelles containing multiblock copolymers, and oxidative degradation products of multiblock copolymers. ...

2012

Nanomaterials for Drug Delivery

Jeffrey Alan Hubbell

American Association for the Advancement of Science2012

Engineering Approaches to Immunotherapy

Jeffrey Alan Hubbell, Melody Swartz, Sachiko Hirosue

As the science of immunology grows increasingly mechanistic, motivation for developing quantitative, design-based engineering approaches has also evolved, both for therapeutic interventions and for elucidating immunological pathways in human disease. This ...

American Association for the Advancement of Science2012

Engineered insulin-like growth factor-1 for improved smooth muscle regeneration

Lirong Yang, Jeffrey Alan Hubbell, Peter Frey, Kristen Lorentz

Insulin-like growth factor-1 (IGF-1) has been shown to induce potent mitogenic responses in various cell types, yet its sustained local delivery is still an underdeveloped domain in the clinic. We report here an engineered IGF-1 that facilitates extended l ...

2012

Polymer micelles with pyridyl disulfide-coupled antigen travel through lymphatics and show enhanced cellular responses following immunization

Jeffrey Alan Hubbell, Melody Swartz, Conlin O'Neil, Jackson Eby, Sachiko Hirosue, Karen Dane

Poly(ethylene glycol)-stabilized poly(propylene sulfide) core (PEG-PPS) nanoparticles (NPs) smaller than 50 nm efficiently travel to draining lymph nodes and interact with antigen-presenting cells (APCs) to induce potent immune responses following intrader ...

Elsevier Sci Ltd2012

Single cell analysis of porcine and human urothelial cells

Jeffrey Alan Hubbell, Yann Barrandon, Peter Frey, Hans Mattias Larsson, François Gorostidi

Wiley-Blackwell2012

In-vivo performance of high-density collagen gel tubes for urethral regeneration in a rabbit model

Lionel Ambroise Micol, Jeffrey Alan Hubbell, Peter Frey

Congenital malformations or injuries of the urethra can be treated using existing autologous tissue, but these procedures are sometimes associated with severe complications. Therefore, tissue engineering may be advantageous for generating urethral grafts. ...

Elsevier2012

Exploring the growth factor-binding properties of osteopontin

Mikaël Martino, Jeffrey Alan Hubbell, Federico Tortelli

Wiley-Blackwell2012

Long-term maintenance of mouse embryonic stem cell pluripotency by manipulating integrin signaling within 3D scaffolds without active Stat3

Jeffrey Alan Hubbell, Stephane Kontos, Seung Tae Lee, Jungim Yun

We engineered an acellular biomimetic microenvironment to regulate stem cell fate and applied it to maintain mouse embryonic stem (ES) cell self-renewal. In the 3D environment formed using hydrogel scaffolds in which specific integrin ligation was provided ...

Elsevier Sci Ltd2012

Twenty-Third Annual Pezcoller Symposium: Engineering Influences in Cancer Research

Jeffrey Alan Hubbell

The cross-disciplinary focus of the meeting highlighted recent progress in physical and genetic analysis and engineering of cancer disease models. As the central theme, mechanical forces affecting cell signaling, growth, differentiation, and metastasis wer ...

2012

Compressed fibrin-collagen scaffolds for enhancing bladder tissue regeneration: a bioreactor cell culture system

Jeffrey Alan Hubbell, Peter Frey, Eva-Maria Balet, Elif Vardar

Wiley-Blackwell2012

Embryonic Stem Cell-Based Cardiopatches Improve Cardiac Function in Infarcted Rats

Jeffrey Alan Hubbell

Pluripotent stem cell-seeded cardiopatches hold promise for in situ regeneration of infarcted hearts. Here, we describe a novel cardiopatch based on bone morphogenetic protein 2-primed cardiac-committed mouse embryonic stem cells, embedded into biodegradab ...

AlphaMed Press2012

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