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Theo Lasser

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Publications associées (125)

Visible light optical coherence correlation spectroscopy

Heinrich Hofmann, Marcel Leutenegger, Theo Lasser, Stéphane Broillet, Arno Pino Bouwens, Lionel André Maurizi, Daniel Pawel Szlag

Optical coherence correlation spectroscopy (OCCS) allows studying kinetic processes at the single particle level using the backscattered light of nanoparticles. We extend the possibilities of this technique by increasing its signal-to-noise ratio by a fact ...

Optical Society of America2014

Quantitative cerebral blood flow imaging with extended-focus optical coherence microscopy

Theo Lasser, Corinne Berclaz, Tristan Bolmont, Arno Pino Bouwens, Daniel Pawel Szlag

Quantitative three-dimensional blood flow imaging is a valuable technique to investigate the physiology of the brain. Two-photon microscopy (2PM) allows quantification of the local blood flow velocity with micrometric resolution by performing repeated line ...

Optical Society of America2014

Use of waste products for detecting amyloidogenic proteinaceous material in living mammals

Theo Lasser, Patrick Fraering, Tristan Bolmont, Taoufiq Harach

Method for detecting amyloidogenic proteinaceous material induced by a proteopathy, for instance Alzheimer's disease, characterized by the fact that said amyloidogenic proteinaceous material is detected in a mammal waste product, such as feces. ...

2013

Engineering absorption losses in plasmonic nanostructures

Theo Lasser, Olivier Martin, Krishnan Thyagarajan, Banafsheh Abasahl

2013

HILBERT TRANSFORM RELATIONS IN FREQUENCY-DOMAIN OPTICAL-COHERENCE TOMOGRAPHIC IMAGING

Theo Lasser, Chandra Sekhar Seelamantula

Interferometric imaging techniques typically embed the object phase information in the magnitude during the measurement process. During reconstruction, the phase is recovered from the magnitude by certain approximations on the measured magnitude and underl ...

2013

High speed laser Doppler perfusion imaging system e.g. blood flow imaging system, detects laser Doppler signal and/or laser speckle signal from light reflected from selected blood vessel area, to obtain flow data

Theo Lasser

An instrument for high-speed laser perfusion imaging comprises a laser source, a detector, a signal-processing unit, data memory, and a screen to display the results. A section of the sample surface is illuminated with laser light; the reemitted light from ...

2013

How to display data by color schemes compatible with red-green color perception deficiencies

Theo Lasser

Visualization of data concerns most scientists. The use of color is required in order to display multidimensional information. In addition, color encoding a univariate image can improve the interpretation significantly. However up to 10% of the adult male ...

Optical Society of America2013

Quantitative lateral and axial flow imaging with optical coherence microscopy and tomography

Theo Lasser, Tristan Bolmont, Arno Pino Bouwens, Daniel Pawel Szlag

Optical coherence tomography (OCT) and optical coherence microscopy (OCM) allow the acquisition of quantitative three-dimensional axial flow by estimating the Doppler shift caused by moving scatterers. Measuring the velocity of red blood cells is currently ...

Optical Society of America2013

Mapping molecular statistics with balanced super-resolution optical fluctuation imaging (bSOFI)

Marcel Leutenegger, Theo Lasser, Claudio Dellagiacoma, Corinne Berclaz, Noelia Laura Bocchio, Stefan Geissbuehler

Super-resolution optical fluctuation imaging (SOFI) achieves 3D super-resolution by computing temporal cumulants or spatio-temporal cross-cumulants of stochastically blinking fluorophores. In contrast to localization microscopy, SOFI is compatible with wea ...

2012

Diabetes imaging — quantitative assessment of islets of Langerhans distribution in murine pancreas using extended-focus optical coherence microscopy

Anthony Christopher Davison, Theo Lasser, Martin Villiger, Dimitri Nestor Alice Van De Ville, Anne Grapin-Botton, Corinne Berclaz, Joan Goulley, Erica Martin-Williams, Arno Pino Bouwens

Diabetes is characterized by hyperglycemia that can result from the loss of pancreatic insulin secreting β-cells in the islets of Langerhans. We analyzed ex vivo the entire gastric and duodenal lobes of a murine pancreas using extended-focus Optical Cohere ...

2012

Assessment of transferrin recycling by Triplet Lifetime Imaging in living cells

Theo Lasser, Harm-Anton Klok, Zuzana Kadlecova

An optical method is presented that allows the measurement of the triplet lifetime of a fluorescent molecule. This is a characteristic specific to each fluorophore. Based on differences in triplet lifetimes of two fluorescent species (autofluorescence vers ...

Optical Soc Amer2012

Fast three-dimensional imaging of gold nanoparticles in living cells with photothermal optical lock-in Optical Coherence Microscopy

Christian Santschi, Theo Lasser, Martin Villiger, Corinne Berclaz, Christophe Pache, Matthew Gibson, Joan Goulley, Noelia Laura Bocchio, Arno Pino Bouwens

We introduce photothermal optical lock-in Optical Coherence Microscopy (poli-OCM), a volumetric imaging technique, which combines the depth sectioning of OCM with the high sensitivity of photothermal microscopy while maintaining the fast acquisition speed ...

Optical Society of America2012

Triplet imaging of oxygen consumption during the contraction of a single smooth muscle cell (A7r5)

Iwan Märki, Marcel Leutenegger, Theo Lasser, Kai Johnsson, Matthias Geissbühler, Dimitri Nestor Alice Van De Ville, Boris Hinz, Thiemo Spielmann, Aurélie Formey de Saint Louvent

Triplet imaging is a novel optical technique that allows investigating oxy- gen metabolism at the single cell and the sub-cellular level. The method combines high temporal and spatial resolution, which are required for the monitoring of fast kinetics of ox ...

Springer Science+Business Media2012

Cumulant microscopy

Theo Lasser, Claudio Dellagiacoma, Stefan Geissbuehler

The invention describes a method and a microscopy system for imaging and analysing stochastically and independently blinking point-like emitters. A multiple-order cumulants analysis in conjunction with an established blinking model enables the extraction o ...

2012

Zero-crossing approach to high-resolution reconstruction in frequency-domain optical-coherence tomography

Marcel Leutenegger, Theo Lasser, Chandra Sekhar Seelamantula, Arno Pino Bouwens

We address the problem of high-resolution reconstruction in frequency-domain optical-coherence tomography (FDOCT). The traditional method employed uses the inverse discrete Fourier transform, which is limited in resolution due to the Heisenberg uncertainty ...

2012

Real-time Full Field Laser Doppler Imaging

Marcel Leutenegger, Theo Lasser, Tyler Nerton Thacher

We present a full field laser Doppler imaging instrument that enables real-time in vivo assessment of blood flow in dermal tissue and skin. The instrument monitors the blood perfusion in an area of about 50cm2 with 480 x 480 pixels per frame at a rate of 1 ...

Amer Inst Physics2012

Nonlinear Correlation Spectroscopy (NLCS)

Iwan Märki, Marcel Leutenegger, Theo Lasser, Jean-Pierre Wolf, Luigi Bonacina, Noelia Laura Bocchio, Stefan Geissbuehler

We present a novel concept for optical spectroscopy called nonlinear correlation spectroscopy (NLCS). NLCS analyses coherent field fluctuations of the second and third harmonic light generated by diffusing nanoparticles. Particles based on noncentrosymmetr ...

American Chemical Society2012

Label-free imaging of cerebral β-amyloidosis with extended-focus optical coherence microscopy

Theo Lasser, Martin Villiger, Corinne Berclaz, Christophe Pache, Patrick Fraering, Tristan Bolmont, Mitko Dimitrov, Arno Pino Bouwens

We demonstrate label-free imaging of cerebral β-amyloidosis ex vivo and in a living mouse model of Alzheimer's disease using extended focus Fourier domain optical coherence microscopy (xfOCM). xfOCM provides 3D, high-resolution images of individual β-amylo ...

Society for Neuroscience2012

Comparison between SOFI and STORM

Theo Lasser, Claudio Dellagiacoma, Stefan Geissbühler

A straightforward method to achieve super-resolution consists of taking an image sequence of stochastically blinking emitters using a standard wide-field fluorescence microscope. Densely packed single molecules can be distinguished sequentially in time usi ...

2011

Nanofluidic biosensor and its use for rapid measurement of biomolecular interactions in solution and methods

Theo Lasser, Nicolas Durand, Yannick Sébastien Fournier

A method and device for the rapid detection of biomolecules (320) diffusing in a nanometer-confined slit (204) is claimed. In particular, the present invention relates to a novel concept of fluidic side apertures (205) that facilitates the filling of the d ...

2011

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