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Matthias Lütolf

Cette personne a quitté l’EPFL

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Publications associées (176)

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Methods & compounds useful in hematopoietic stem cell medicine

Matthias Lütolf, Nicola Vannini, Johan Auwerx, Mukul Girotra, Olaia Maria Naveiras Torres-Quiroga

The present invention relates to a specific marker for stem cells having long-term multi-lineage blood reconstitution capability and uses thereof for the preparation of cell composition in view of hematopoietic stem cell medicine and in particular regenera ...

2016

Recapitulating macro-scale tissue self-organization through organoid bioprinting

Matthias Lütolf, Moritz Hofer, Mikhail Nikolaev

A 3D bioprinting approach has been developed to facilitate tissue morphogenesis by directly depositing organoid-forming stem cells in an extracellular matrix, with the ability to generate intestinal epithelia and branched vascular tissue constructs. ...

NATURE RESEARCH2021

Microfluidic Patterning of Protein Gradients on Biomimetic Hydrogel Substrates

Matthias Lütolf, Steffen Cosson

This protocol describes a versatile microfluidic method to generate tethered protein gradients of virtually any user-defined shape on biomimetic hydrogel substrates. It can be applied to test, in a microenvironment of physiologically relevant stiffness, ho ...

Elsevier Academic Press Inc2014

Sorting Live Stem Cells Based on Sox2 mRNA Expression

Matthias Lütolf, Jeffrey Alan Hubbell, Peter Frey, Hans Mattias Larsson

While cell sorting usually relies on cell-surface protein markers, molecular beacons (MBs) offer the potential to sort cells based on the presence of any expressed mRNA and in principle could be extremely useful to sort rare cell populations from primary i ...

Public Library of Science2012

Automated analysis of single stem cells in microfluidic traps

Matthias Lütolf, Olivier Burri, Alessandra Griffa, Stefan Kobel, Arne Seitz, Mukul Girotra

We report a reliable strategy to perform automated image cytometry of single (non-adherent) stem cells captured in microfluidic traps. The method rapidly segments images of an entire microfluidic chip based on the detection of horizontal edges of microflui ...

2012

Open-source microscope add-on for structured illumination microscopy

Matthias Lütolf, Theo Lasser, Aleksandra Radenovic, John McKinney, Georg Fantner, Olivier François Venzin, Mélanie Thérèse Marie Hannebelle, Tomas Lukes, Samuel Mendes Leitão, Antonius Chrisnandy, Chiara Toniolo, Andrew Charles Oates, Esther Braun, Prabhu Prasad Swain, Nathan Cyprien Arsène Ronceray

Super-resolution techniques expand the abilities of researchers who have the knowledge and resources to either build or purchase a system. This excludes the part of the research community without these capabilities. Here we introduce the openSIM add-on to ...

Nature Portfolio2024

Three dimensional hydrogels for culturing organoids

Matthias Lütolf, Nikolche Gjorevski

The invention provides hydrogels and methods for three-dimensional (3D) culture of adult epithelial stem cells and uses thereof. ...

2017

Measuring reporter activity domain in EPI aggregates and Gastruloids.ijm

Matthias Lütolf, Olivier Burri, Romain Guiet, Mehmet Ugur Girgin

This imagej macro analyses the reporter intensity activity and expression domain in EPI aggregates and Gastruloids. ...

Zenodo2022

In vitro human cell-based models: What can they do and what are their limitations?

Matthias Lütolf

It is said that all models are wrong, but some are useful. In vitro human cell-based models are a prime example of this maxim. We asked researchers: when is your model system useful? How can it be made more useful? What are its limitations? ...

CELL PRESS2024

Method for preparing topographically structured microarrays

Matthias Lütolf, Samy Gobaa

A method for preparing a topographically structured hydrogel microarray is described comprising the steps of a) providing one or more types of biomolecule(s) on top of micropillars of an array of micropillars, preferably by means of robotical spotting, b) ...

2013

Matthias Lutolf, interviewed by Peter Loskill (Vice-Chair of EUROoC, the European-Organ-on-Chip-Society)

Matthias Lütolf

CELL PRESS2021

Arrays of discrete cell culture microenvironments, methods of making such arrays and uses thereof

Matthias Lütolf, Adrian Ranga

The invention pertains to a combinatorial method of identifying the hydrogel formulations controlling phenotype and fate of difficult-to-culture cell types. ...

2016

Three dimensional models of tissue fibrosis

Matthias Lütolf, Kristina Schoonjans, Saba Rezakhani, Ece Yildiz, Giovanni Sorrentino

The invention provides a method for obtaining a three-dimensional (3D) cellular model of tissue fibrosis, such as liver fibrosis, comprising culturing epithelial cells in a 3D hydrogel in conditions suitable for a three-dimensional cellular cluster formati ...

2020

High-Throughput Screening Of Stem Cell Microenvironments

Matthias Lütolf

Wiley-Blackwell2013

Device for manipulating mammalian cells with high collection capability

Matthias Lütolf, Nathalie Brandenberg, Sylke Höhnel

2021

The NAD plus Salvage Pathway Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance and Asymmetric Division

Matthias Lütolf, Bart Deplancke, Nicola Vannini, Carlos Canto Alvarez, Mukul Girotra, Aurélien Laurent Jean-Charles Oggier, Dongryeol Ryu, Eija Riitta Pirinen, Olaia Maria Naveiras Torres-Quiroga, Pernille Yde Rainer, Gennady Nikitin, Vasco Ledebur de Antas de Campos, Joanna Ratajczak, Josefine Catharina Pedersen Tratwal, George Coukos, Sonja Giger, Shanti Rojas-Sutterlin, Yang Li

AMER SOC HEMATOLOGY2018

Breaking the Barriers in Engineering Organoids and Tissues with Advanced Materials

Matthias Lütolf

2020

Organoid tissue engineering

Matthias Lütolf, Yoji Tabata, Nathalie Brandenberg, Nikolche Gjorevski, Mikhail Nikolaev, Sara Filipa Da Silva Geraldo Alves

The invention relates to methods for developing and maintaining organoids and the organoids produced thereby. ...

2018

Microfluidic devices

Matthias Lütolf, Jisoo Park

The present disclosure relates to a microfluidic device comprising: a substrate; a culture chamber (130); a loading channel (170) in fluid communication with the culture chamber; at least one auxiliar channel (170-1, 5 170-2) extending from and in fluid co ...

2023

Natural polymer-derived scaffold material and methods for production thereof

Matthias Lütolf, Jeffrey Alan Hubbell, Peter Frey, Hans Mattias Larsson, Simone Allazetta, Elif Vardar

The invention relates to a scaffold material comprising a carrier and embedded microbeads for use in tissue engineering applications such as soft tissues therapeutic treatment. The scaffold provides a short-term bulking effect coupled with a long-term func ...

2017