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Matthias Lütolf

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Publications associées (180)

Engineering biomimetic hydrogels for induced recruitment of mesenchymal stem cells in vitro and in vivo

Matthias Lütolf, Philipp Sebastian Lienemann, Martin Ehrbar, Olaia Maria Naveiras Torres-Quiroga

Wiley-Blackwell2012

Keynote: Engineering homing and differentiation of mesenchymal progenitor cells during bone healing

Matthias Lütolf, Philipp Sebastian Lienemann, Martin Ehrbar

Wiley-Blackwell2012

Automated analysis of single stem cells in microfluidic traps

Matthias Lütolf, Olivier Burri, Alessandra Griffa, Stefan Kobel, Arne Seitz, Mukul Girotra

We report a reliable strategy to perform automated image cytometry of single (non-adherent) stem cells captured in microfluidic traps. The method rapidly segments images of an entire microfluidic chip based on the detection of horizontal edges of microflui ...

2012

In Vivo Modulation of Mitochondrial Activity Determines HSC Engraftment and Post-Transplant Survival in Mice

Matthias Lütolf, Aline Roch, Nicola Vannini, Johan Auwerx, Richardus Houtkooper, Mukul Girotra, Eija Riitta Pirinen, Olaia Maria Naveiras Torres-Quiroga, Vasco Ledebur de Antas de Campos

Amer Soc Hematology2012

High-throughput approaches for the analysis of extrinsic regulators of stem cell fate

Matthias Lütolf, Adrian Ranga

The complexity of stem cell niches poses a tremendous challenge to understanding mechanisms of extrinsic regulation of stem cell fate. In order to better understand niche signaling and its effect on stem cell fate choices, in vitro systems are being engine ...

2012

Sorting Live Stem Cells Based on Sox2 mRNA Expression

Matthias Lütolf, Jeffrey Alan Hubbell, Peter Frey, Seung Tae Lee, Hans Mattias Larsson

While cell sorting usually relies on cell-surface protein markers, molecular beacons (MBs) offer the potential to sort cells based on the presence of any expressed mRNA and in principle could be extremely useful to sort rare cell populations from primary i ...

Public Library of Science2012

Controlled Breast Cancer Microarrays for the Deconvolution of Cellular Multilayering and Density Effects upon Drug Responses

Matthias Lütolf, Stefan Kobel

Background: Increasing evidence shows that the cancer microenvironment affects both tumorigenesis and the response of cancer to drug treatment. Therefore in vitro models that selectively reflect characteristics of the in vivo environment are greatly needed ...

Public Library of Science2012

High-throughput clonal analysis of neural stem cells in microarrayed artificial niches

Matthias Lütolf, Samy Gobaa

To better understand the extrinsic signals that control neural stem cell (NSC) fate, here we applied a microwell array platform which allows high-throughput clonal analyses of NSCs, cultured either as neurospheres or as adherent clones, exposed to poly(eth ...

2012

Keynote: Deconstructing and reconstructing stem cell niches

Matthias Lütolf, Adrian Ranga, Samy Gobaa

Wiley-Blackwell2012

Predicting stem cell fate changes by differential cell cycle progression patterns

Matthias Lütolf, Daniel Sage, Daniel Andreas Schmitter, Yuya Okawa, Marlen Knobloch

Stem cell self-renewal, commitment and reprogramming rely on a poorly understood coordination of cell cycle progression and execution of cell fate choices. Using existing experimental paradigms, it has not been possible to probe this relationship systemati ...

Company of Biologists2012

Elucidating the Role of Matrix Stiffness in 3D Cell Migration and Remodeling

Matthias Lütolf, Katarzyna Mosiewicz, Adrian Ranga, Philipp Sebastian Lienemann, Martin Ehrbar

Reductionist in vitro model systems which mimic specific extracellular matrix functions in a highly controlled manner, termed artificial extracellular matrices (aECM), have increasingly been used to elucidate the role of cell-ECM interactions in regulating ...

Elsevier2011

Artificial niche microarrays for probing single stem cell fate in high throughput

Matthias Lütolf, Stefan Kobel, Samy Gobaa, Andrea Negro

To understand the regulatory role of niches in maintaining stem-cell fate, multifactorial in vitro models are required. These systems should enable analysis of biochemical and biophysical niche effectors in a combinatorial fashion and in the context of a p ...

Nature Publishing Group2011

In vitro platforms for tissue engineering: implications for basic research and clinical translation

Matthias Lütolf

Clinical translation of engineered tissues into regenerative medicine applications, and the effort to reduce the use of animals for the screening of drugs and other compounds, result in an increasing demand for human tissues engineered in vitro for implant ...

Wiley-Blackwell2011

Biomaterials meet microfluidics: building the next generation of artificial niches

Matthias Lütolf, Stefan Kobel

Biomaterials are increasingly being developed as in vitro microenvironments mimicking in vivo stem cell niches. However, current macroscale methodologies to produce these niche models fail to recapitulate the spatial and temporal characteristics of the com ...

Elsevier2011

Engineering 3D cell instructive microenvironments by rational assembly of artificial extracellular matrices and cell patterning

Matthias Lütolf, Adrian Ranga, Martin Ehrbar

Engineered artificial microenvironments hold enormous potential as models to study developmental, physiological, pathological, and regenerative processes under highly defined conditions. Such platforms aim at bridging the gap between traditional in vitro 2 ...

2011

Programmable microfluidic patterning of protein gradients on hydrogels

Matthias Lütolf, Steffen Cosson, Simone Allazetta

Computer-controlled hydrodynamic flow focusing was utilized to generate tethered protein gradients of any user-defined shape on the surface of soft synthetic hydrogels. ...

Royal Society of Chemistry2010

The effect of matrix characteristics on fibroblast proliferation in 3D gels

Matthias Lütolf, Jeffrey Alan Hubbell, Martin Ehrbar, Simone Rizzi

Engineering synthetic hydrogels on a molecular basis to introduce natural features that are important in instructing cell behavior is becoming increasingly crucial in biomaterial-based approaches for regenerative medicine and in cell biology to study cell– ...

Elsevier2010

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

Matthias Lütolf, Nora Leonardi

Freshly isolated muscle stem cells (MuSCs) exhibit robust regenerative capacity in vivo that is rapidly lost in culture. Using a bioengineered substrate to recapitulate key biophysical and biochemical niche features in conjunction with a novel highly autom ...

American Association for the Advancement of Science2010

Optimization of microfluidic single cell trapping for long-term on-chip culture

Matthias Lütolf, Philippe Renaud, Jonas Marcel Lätt, Stefan Kobel, Ana Valero

The poor efficiency of microfluidic single cell trapping is currently restricting the full potential of state-of-the-art single cell analyses. Using fluid dynamics simulations in combination with particle image velocimetry to systematically optimize trap a ...

Royal Society of Chemistry2010

High-Fidelity Printing Strategies for Printing 3D Vascular Hydrogel Structures

Matthias Lütolf, Philippe Renaud, Jürgen Brugger, Thomas Michael Braschler, Kristopher Pataky

Vascularization arguably poses the most significant hurdle for the success of most biomaterials-based tissue engineering therapies. In this work, we report two printing strategies that permit the 3D Inkjet printing of fluorescent alginate hydro gels into o ...

Soc Imaging Science & Technology, 7003 Kilworth Lane, Springfield, Va 22151 Usa2009

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