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Heinrich Hofmann

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Publications associées (121)

The in vivo performance of magnetic particle-loaded injectable, in situ gelling, carriers for the delivery of local hyperthermia

Olivier Jordan, Heinrich Hofmann, Antonin Faes, Alke Fink, Daniel Ruefenacht

In situ forming implants are attractive for minimally invasive localized therapies such as aneurysm embolization. As for the superparamagnetic iron oxide nanoparticles (SPIONs), their deposition/injection in a target tissue area allows magnetically induced ...

2010

Synthesis and Characterization of SiO2 Coated γ-Fe2O3 Nanocomposite Powder for Hyperthermic Application

Heinrich Hofmann

SiO2 coated γ-Fe2O3 nanocomposite powder has been successfully synthesized by chemical vapor condensation process and its feasibility on hyperthermic application was investigated in this study. The power loss of SiO2 coated γ-Fe2O3 nanocomposite powder whi ...

2010

Control of morphology and nanostructure of copper and cobalt oxalates: Effect of complexing ions, polymeric additives and molecular weight

Nathalie Jongen, Paul Bowen, Heinrich Hofmann, Jacques Lemaître, Alke Fink

Precipitated oxalates are often nanostructured and can be used as precursors for nanostructured oxides for different applications. The modification of the particle shape and nanostructures of both copper and cobalt oxalates has been demonstrated using poly ...

2010

In vivo labelling of resting monocytes in the reticuloendothelial system with fluorescent iron oxide nanoparticles prior to injury reveals that they are mobilized to infarcted myocardium

Heinrich Hofmann, Alke Fink, Jean-Noël Hyacinthe

To evaluate the feasibility of loading resting monocytes/macrophages by intravenous (i.v.) injection of fluorescent iron oxide nanoparticles prior to injury and tracking of these cells in the very same animal to myocardial infarction (MI) by magnetic reson ...

Oxford University Press2010

Fabrication and Characterisation of Cathode Support-tubes for Micro-tubular SOFC Application

Stefan Diethelm, Paul Bowen, Heinrich Hofmann, Jan Van Herle, John Espen Rossen

Tubes of diameter

2009

Exposure to super-paramagnetic iron oxide nanoparticles reduces dendritic cell-dependent antigen-specific T-cell proliferation

Heinrich Hofmann, Alke Fink

Swiss Medical Publishers Ltd / EMH Swiss Medical Publishers2009

Nanostructured Ceramic Coatings for Drug Delivery

Heinrich Hofmann, Laurent-Dominique Piveteau, Arnaud Tourvieille de Labrouhe, Karin Dittmar

Drug eluting stents (DES) have been successfully implemented in clinical practice in the treatment against coronary artery disease. Compared to the implantation of bare metal stents, restenosis rates decreased significantly after stenting of DES into coron ...

Materials Research Society, 506 Keystone Drive, Warrendale, Pa 15086-7573 Usa2009

Particle Size Distribution Measurements of Manganese-Doped ZnS Nanoparticles

Heinrich Hofmann, Alke Fink

We performed particle size and particle size distribution measurements for L-cysteine-stabilized ZnS/Mn nanoparticles in the size region below 10 nm. For this we applied transmission electron microscopy (TEM), analytical ultracentrifugation (AUC), dynamic ...

2009

Magnetic, paramagnetic and/or superparamagnetic nanoparticles

Heinrich Hofmann, Alke Fink, Benedikt Steitz, Andrija Finka, Jatuporn Salaklang

The present invention relates to nanoparticles having a mean diameter of < 500nm and comprising, at their surface, a selected material. The nanoparticles are taken up by cells under physiological conditions and can be used to isolate interaction partners o ...

2009

Ceramic particles and layers for functional application

Heinrich Hofmann

Besides 'bulk' structural and functional ceramic, a third interesting group of inorganic or ceramic materials exists: particles used for medical applications like contrast agent as building blocks for photonic crystals, as thin or thick layers with control ...

2009

Surface-Functionalized Ultrasmall Superparamagnetic Nanoparticles as Magnetic Delivery Vectors for Camptothecin

Heinrich Hofmann

The linking of therapeutic drugs to ultrasmall superparamagnetic iron oxide nanoparticles (USPIOs) allowing intracellular release of the active drug via cell-specific mechanisms would achieve tumor-selective magnetically-enhanced drug delivery. To validate ...

Wiley-Blackwell2009

Local moderate magnetically induced hyperthermia using an implant formed in situ in a mouse tumor model

Olivier Jordan, Heinrich Hofmann, Alke Fink

Purpose: We investigate a new heat delivery technique for the local treatment of solid tumors. The technique involves injecting a formulation that solidifies to form an implant in situ. This implant entraps superparamagnetic iron oxide nanoparticles (SPION ...

Taylor & Francis2009

Cathode-supported micro-tubular SOFCs based on Nd1.95NiO4 + δ: Fabrication and characterisation of dip-coated electrolyte layers

Paul Bowen, Heinrich Hofmann, Jan Van Herle, Ulrich Aschauer, Josef Andreas Schuler, Henning Lübbe

Fabrication conditions to obtain dense electrolyte double layers on a porous micro-tubular cathode substrate were investigated. Porous tubes of a nickelate material, Nd1.95NiO4 + δ, were fabricated by cold-isostatic pressing (CIP) and sintering. Thin ﬁlms ...

2009

Superparamagnetic Nanoparticles as a Powerful Systems Biology. Characterization Tool in the Physiological Context

Heinrich Hofmann, Alke Fink, Jeffrey Alan Hubbell, Benedikt Steitz, Conlin O'Neil, Marc Moniatte, Andrija Finka, Jatuporn Salaklang

Recently, functionalized superparamagnetic iron oxide nanoparticles (SPIONs) have been utilized for protein separation and therapeutic delivery of DNA and drugs. The development of new methods and tools for the targeting and identification of specific biom ...

Wiley-Blackwell2008

Growth modification of hematite by phosphonate additives

Paul Bowen, Heinrich Hofmann, Ulrich Aschauer

The hydroxylated surface structures of seven morphologically important crystallographic surfaces of hematite were calculated allowing the determination of the surface energies and, consequently,the hematite equilibrium morphology. The docking of two organi ...

2008

Dielectrophoresis-based particle exchanger for the manipulation and surface functionalization of particles

Heinrich Hofmann, Philippe Renaud, Nicolas Demierre, Raphaël Tornay, Jeffrey Alan Hubbell, Thomas Michael Braschler, Benedikt Steitz, Andrija Finka

We present a microfluidic device where micro- and nanoparticles can be continuously functionalized in flow. This device relies on an element called particle exchanger, which allows for particles to be taken from one medium and exposed to some reagent while ...

2008

Application of pulsed-magnetic field enhances non-viral gene delivery in primary cells from different origins

Heinrich Hofmann, Alke Fink, Benedikt Steitz

Primary cell lines are more difficult to transfect when compared to immortalized/transformed cell lines, and hence new techniques are required to enhance the transfection efficiency in these cells. We isolated and established primary cultures of synoviocyt ...

2008

Effect of cell media on polymer coated superparamagnetic iron oxide nanoparticles (SPIONs): Colloidal stability, cytotoxicity, and cellular uptake studies

Heinrich Hofmann, Alke Fink, Benedikt Steitz, Andrija Finka, Jatuporn Salaklang

The influence of the composition of the polymer coated polyvinyl alcohol (PVA), vinyl alcohol/vinyl amine copolymer (A-PVA) and polyethylenimine (PEI) coated superparamagnetic iron oxide nanoparticles (SPIONs) on the colloidal stability, cytotoxicity and c ...

2008

Investigation of immune responses to engineered nanoparticles

Heinrich Hofmann

Swiss Medical Publishers Ltd / EMH Swiss Medical Publishers2008

Optical properties of annealed Mn2+-doped ZnS nanoparticles

Heinrich Hofmann, Alke Fink, Yvonne Axmann, Benedikt Steitz

Cysteine stabilized ZnS and Mn2+-doped ZnS nanoparticles were synthesized by a wet chemical route. Using the ZnS:Mn2+ nanoparticles as seeds, silica-coated ZnS (ZnS@Si) and ZnS:Mn2+ (ZnS:Mn2+@Si) nanocomposites were formed in water by hydrolysis and conden ...

2008

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