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Heinrich Hofmann

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Publications associées (121)

Engineered nanoparticles for gene delivery in a bleomycin-injured lung fibrosis model

Heinrich Hofmann, Alke Fink

Swiss Medical Publishers Ltd / EMH Swiss Medical Publishers2008

Solder Doped Polycaprolactone Scaffold Enables Solder Doped Polycaprolactone Scaffold Enables. Reproducible Laser Tissue Soldering

Heinrich Hofmann, Alke Fink, Vianney Bernau

During the last 40 years a focus in research was put on sutureless tissue fusion, to handle the limits of conventional suturing such as vascular wall damage due to the enetrating needle, intraluminal foreign body reactions caused by non-absorbable suture m ...

2008

In-situ electrical addressing of one-dimensional gold nanoparticle assemblies

Heinrich Hofmann, Frédéric Juillerat

Substrates with 1-dimensional nanosize grooves were prepared using extreme-ultraviolet interference lithography (EUV-IL), wherein gold nanoparticles were self-assembled to form 1-dimensional structures. To measure the electrical properties of gold nanopart ...

2008

Superparamagnetic iron oxide nanoparticle coupled tissue soldering

Heinrich Hofmann, Alke Fink, Benedikt Steitz

The invention relates to superparamagnetic iron oxide nanoparticles for use in sutureless thermal mediated tissue fusion. The nanoparticles are dispersed in a biocompatible solder material and heated by application of an alternating electromagnetic field. ...

2007

Superparamagnetic iron oxide nanoparticles (SPIONs): from synthesis to in vivo studies - A summary of the synthesis, characterization, in vitro and in vivo investigations of SPIONs with particular focus on surface and colloidal properties

Heinrich Hofmann, Alke Fink

In this work, we present a short summary of the synthesis and characterization of superparamagnetic iron oxide nanoparticles and their behavior in vitro and in vivo. Therefore, we have used various characterization techniques to deduce the physical particl ...

2007

PRODUCTION AND BIOFUNCTIONALIZATION OF MAGNETIC NANOBEADS FOR MAGNETIC SEPARATION OF MESSENGER RNA

Heinrich Hofmann, Alke Fink, Benedikt Steitz

The synthesis of nanosized beads of superparamagnetic iron oxide nanoparticles coated with 3-(aminopropyl)triethoxysilane is reported in this paper. The resulting beads are agglomerates of SPIONs with an open fractal like structure. These beads have been e ...

2007

Superparamagnetic iron oxide binding and uptake as imaged by magnetic resonance is mediated by the integrin receptor Mac-1 (CD11b/CD18): Implications on imaging of atherosclerotic plaques

Heinrich Hofmann, Alke Fink, Benedikt Steitz

Introduction: Superparamagnetic iron oxide nanoparticles (SPIONs) have been successfully used for magnetic resonance imaging (MRI) of atherosclerotic plaques. Endocytosis into monocytes/macrophages has been proposed as the mechanism for SPION uptake, but a ...

2007

Characterization of PEI-coated superparamagnetic iron oxide nanoparticles for transfection: Size distribution, colloidal properties and DNA interaction

Heinrich Hofmann, Alke Fink, Benedikt Steitz

Superparamagnetic iron oxide nanoparticles (SPIONs) were coated with polyethylenimine. Here, we briefly describe the synthesis as well as DNA:PEI:SPION complexes and the characterization of the compounds according to their particle size, zeta-potential, mo ...

2007

Positional Control of Superparamagnetic Iron Oxide Nanoparticles in Silica Beads U

Heinrich Hofmann, Alke Fink, Sandrine Gay, Benedikt Steitz, Franziska Krauss

2007

Fixed bed reactor for solid phase surface derivatization of superparamagnetic nanoparticles

Heinrich Hofmann, Alke Fink, Benedikt Steitz, Andrija Finka, Jatuporn Salaklang

The functionalization of nanoparticles is conditio sine qua non in studies of specific interaction with a biological target. Often, their biological functionality is achieved by covalent binding of bioactive molecules on a preexisting single surface coatin ...

2007

INJECTABLE SUPERPARAMAGNETIC NANOPARTICLES FOR TREATMENT BY HYPERTHERMIA AND USE FOR FORMING AN HYPERTHERMIC IMPLANT

Olivier Jordan, Heinrich Hofmann, Mathieu Chastellain, Alke Fink

The injectable formulation for treatment by hyperthermia comprises a liquid carrier and heat-generating superparamagnetic iron oxide nanoparticles having a mean diameter not greater than 20 nm. Said injectable formulation is able to form in-situ a hyperthe ...

2006

SU-8 nanocomposite photoresist with low stress properties for microfabrication applications

Heinrich Hofmann, Philippe Renaud, Arnaud Bertsch, Sébastien Jiguet

2006

Domain structure and optical properties of colloidal photonic crystal

Heinrich Hofmann

Thin colloidal photonic crystals were grown using shear-flow crystallization of polystyrene colloidal nanoparticles. The arrays consist of two types of domains, which are clearly visible on scanning electron microscopy patterns. Both domains have cubic clo ...

2006

A thermodynamic model for the precipitation of nanostructured copper oxalates

Paul Bowen, Heinrich Hofmann, Jacques Lemaître, Lucica Soare

A thermodynamic model is developed for the precipitation of copper oxalate from aqueous solutions of copper nitrate and sodium oxalate in a small well-mixed batch reactor. This model is then used to explain the discrepancy between experimental pH evolution ...

2006

Nanoparticules à noyau métallique recouvert de silice

Heinrich Hofmann, Alke Fink

The invention relates to nanoparticles based on a metal, on a metal alloy or on a metal derivative coated with a silica layer, in which the silica is crystalline silica, in particular crystalline silica in the cristobalite form. They may be prepared from n ...

2006

Systemic Distribution and Elimination of Plain and with Cy3.5 Functionalized Poly(vinyl alcohol) Coated Superparamagnetic Maghemite Nanoparticles After Intraarticular Injection in Sheep In Vivo

Heinrich Hofmann, Alke Fink, Benedikt Steitz

PVA coated and fluorescent dye (Cy3.5) functionalized vinyl alcohol/vinyl amine copolymer coated superparamagnetic iron oxide nanoparticles (SPION) were evaluated for systemic distribution and elimination after intraarticular injection in sheep. Observatio ...

2006

Gene Expression in Synovial Membrane Cells After Intraarticular Delivery of Plasmid-Linked Superparamagnetic Iron Oxide Particles—A Preliminary Study in Sheep

Heinrich Hofmann, Alke Fink, Benedikt Steitz

This study evaluated in vivo gene deliver y and subsequent gene expression within cells of the synovium in the presence of static and pulsating magnetic field application following intraar ticular injection of super paramagnetic iron oxide nanopar ticles l ...

2006

Interaction of Functionalized Superparamagnetic Iron Oxide Nanoparticles with Brain Structures

Heinrich Hofmann, Alke Fink

Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) com-bined with magnetic resonance imaging (MRI) are under clinical evaluation to enhance detection of neurodegenerative diseases. A major improvement would be to link therapeutic drugs to the SPIONs to a ...

2006

Pièce en céramique pigmentée

Heinrich Hofmann, Alke Fink

NOVELTY - The component partially or wholly comprises pigmented ceramic. The pigment comprises nanoparticles of metal of group IB in periodic table, alkaline metals or their alloy, coated with a layer of silica such as crystalline silica. The crystalline s ...

2006

SU-8 nanocomposite coatings with improved tribological performance for MEMS

Heinrich Hofmann, Stefano Mischler, Philippe Renaud, Arnaud Bertsch, Sébastien Jiguet

The increasing interests in micro-electro-mechanical systems (MEMS) has raised the requirement for photoresist materials with improved friction and wear properties for mechanically loaded 3D shaped microstructures. In this work, SU8 photoresist layers rein ...

2006

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