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Heinrich Hofmann

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Publications associées (121)

Highly stretchable dielectric elastomer composites containing high volume fractions of silver nanoparticles

Heinrich Hofmann, Jose Enrico Quijano Quinsaat

The dielectric permittivity (epsilon') of a polymeric material can be significantly increased when blended with conductive fillers at concentrations approaching the percolation threshold. However, reproducible synthesis of such composites is after decades ...

Royal Society of Chemistry2015

The In-Vivo Use of Superparamagnetic Iron Oxide Nanoparticles to Detect Inflammation Elicits a Cytokine Response but Does Not Aggravate Experimental Arthritis

Heinrich Hofmann, Lionel André Maurizi

Background Superparamagnetic Iron Oxide Nanoparticles (SPION) are used in diagnostic imaging of a variety of different diseases. For such in-vivo application, an additional coating with a polymer, for example polyvinyl alcohol (PVA), is needed to stabilize ...

Public Library of Science2015

Monitoring the effects of dexamethasone treatment by MRI using in vivo iron oxide nanoparticle-labeled macrophages

Heinrich Hofmann, Géraldine Sylvie Coullerez, Lionel André Maurizi

Introduction: Rheumatoid arthritis (RA) is a chronic disease causing recurring inflammatory joint attacks. These attacks are characterized by macrophage infiltration contributing to joint destruction. Studies have shown that RA treatment efficacy is correl ...

Biomed Central Ltd2014

Continuous Production of Tailored Silver Nanoparticles by Polyol Synthesis and Reaction Yield Measured by X-ray Absorption Spectroscopy: Toward a Growth Mechanism

Paul Bowen, Heinrich Hofmann, Frank Nüesch, Andrea Testino, Christian Ludwig, Jose Enrico Quijano Quinsaat

Two complementary topics are discussed: (i) the continuous production of silver nanoparticles (AgNPs) and (ii) the measurement of reaction yield by X-ray absorption near-edge spectroscopy (XANES). The continuous polyol synthesis of AgNPs in grams amount an ...

Amer Chemical Soc2014

Ex situ evaluation of the composition of protein corona of intravenously injected superparamagnetic nanoparticles in rats

Heinrich Hofmann, Morteza Mahmoudi, Usawadee Sakulkhu, Lionel André Maurizi, Marie-Gabrielle Chantal Brigitte Ollivier Beuzelin

It is now well recognized that the surfaces of nanoparticles (NPs) are coated with biomolecules (e. g., proteins) in a biological medium. Although extensive reports have been published on the protein corona at the surface of NPs in vitro, there are very fe ...

Royal Soc Chemistry2014

Aqueous stabilisation of carbon-encapsulated superparamagnetic alpha-iron nanoparticles for biomedical applications

Heinrich Hofmann, Géraldine Sylvie Coullerez, Sandra Caroline Galmarini, Lionel André Maurizi, Marie-Gabrielle Chantal Brigitte Ollivier Beuzelin

Carbon-based nanomaterials, such as carbon-encapsulated magnetic nanoparticles (CEMNP, core@shell), show a wide range of desirable properties for applications in the biomedical field (clinical MRI, hyperthermia), for energy production and storage (hydrogen ...

Royal Society of Chemistry2014

Syntheses of cross-linked polymeric superparamagnetic beads with tunable properties

Heinrich Hofmann, Vanessa Mai Dao, Usawadee Sakulkhu, Lionel André Maurizi

A novel, rapid and reproducible method to synthesize functionalized magnetic beads with an original shape is presented. By coating Fe2O3 nanoparticles with PVA, it was possible to tune the size, the number of iron oxide nanoparticles encapsulated and the o ...

RSC Publishing2014

MULTIFUNCTIONALIZED SPIONs FOR NUCLEAR TARGETING: CELL UPTAKE AND GENE EXPRESSION

Heinrich Hofmann, Alke Fink, Jatuporn Salaklang

Superparamagnetic iron oxide nanoparticles (SPIONs) are used in many biological applications, which necessitate intracellular targeting. Here, we investigate intracellular localization and gene expression in HeLa cells after treatment with functionalized S ...

World Scientific Publ Co Pte Ltd2014

Visible light optical coherence correlation spectroscopy

Heinrich Hofmann, Marcel Leutenegger, Theo Lasser, Stéphane Broillet, Arno Pino Bouwens, Lionel André Maurizi, Daniel Pawel Szlag

Optical coherence correlation spectroscopy (OCCS) allows studying kinetic processes at the single particle level using the backscattered light of nanoparticles. We extend the possibilities of this technique by increasing its signal-to-noise ratio by a fact ...

Optical Society of America2014

Amino-polyvinyl Alcohol Coated Superparamagnetic Iron Oxide Nanoparticles are Suitable for Monitoring of Human Mesenchymal Stromal Cells In Vivo

Heinrich Hofmann, Lionel André Maurizi

Mesenchymal stromal cells (MSCs) are promising candidates in regenerative cell-therapies. However, optimizing their number and route of delivery remains a critical issue, which can be addressed by monitoring the MSCs' bio-distribution in vivo using super-p ...

Wiley-Blackwell2014

Nanotechnology in medicine: European research and its implications

Heinrich Hofmann

In this study, we explore and discuss nanoparticles and nanoscale materials and their use in medicine (nanomedicine) and pharmaceutics (nanopharmaceutics). The study is aimed at shedding light on this highly multidisciplinary research field and at examinin ...

E M H Swiss Medical Publishers Ltd2014

Protein Corona Composition of Superparamagnetic Iron Oxide Nanoparticles with Various Physico-Chemical Properties and Coatings

Heinrich Hofmann, Jatuporn Salaklang, Morteza Mahmoudi, Usawadee Sakulkhu, Lionel André Maurizi

Because of their biocompatibility and unique magnetic properties, superparamagnetic iron oxide nanoparticles NPs (SPIONs) are recognized as some of the most prominent agents for theranostic applications. Thus, understanding the interaction of SPIONs with b ...

Nature Publishing Group2014

Impact Of Amino-Pva Coated Nanoparticles On Viability And Cytokine Secretion Of Human Immune Cells Obtained From Healthy Donors And Patients With Rheumatoid Arthritis

Heinrich Hofmann, Lionel André Maurizi

Bmj Publishing Group2014

A fast and reproducible method to quantify magnetic nanoparticle biodistribution

Heinrich Hofmann, Usawadee Sakulkhu, Lionel André Maurizi

The quantification of nanoparticles, particularly superparamagnetic iron oxide nanoparticles (SPIONs), both in vitro and in vivo has become highly important in recent years. Some methods, such as induced coupled plasma (ICP) spectroscopy and UV-visible che ...

Royal Society of Chemistry2014

Impact of PVA Coated Nanoparticles On Cellular Viability and Functionality of Immune Cells Obtained From Healthy Donors and Patients With Rheumatoid Arthritis Or Osteoarthritis

Heinrich Hofmann, Géraldine Sylvie Coullerez

Wiley-Blackwell2013

Dielectric properties of silver nanoparticles coated with silica shells of different thicknesses

Heinrich Hofmann, Jose Enrico Quijano Quinsaat

Core/shell nanoparticles having metallic silver nanoparticle cores of similar to 38 nm in diameter and silica shells of different thicknesses ranging from similar to 3.6-20 nm were prepared. For the silica coating, a slightly modified Stober method was use ...

RSC Publishing2013

Improved dynamic response assessment for intra-articular injected iron oxide nanoparticles

Heinrich Hofmann, Alke Fink, Jatuporn Salaklang

The emerging importance of nanoparticle technology, including iron oxide nanoparticles for monitoring development, progression, and treatment of inflammatory diseases such as arthritis, drives development of imaging techniques. Studies require an imaging p ...

Wiley-Blackwell2012

Evaluation of uptake and transport of ultrasmall superparamagnetic iron oxide nanoparticles by human brain-derived endothelial cells

Heinrich Hofmann

Aim: Ultrasmall superparamagnetic iron oxide nanoparticles (USPIO-NPs) are under development for imaging and drug delivery; however, their interaction with human blood brain barrier models is not known. Materials & Methods: The uptake, reactive oxygen spec ...

2012

Metabolic pathway and distribution of superparamagnetic iron oxide nanoparticles: in vivo study

Heinrich Hofmann

Background: Experimental tissue fusion benefits from the selective heating of superparamagnetic iron oxide nanoparticles (SPIONs) under high frequency irradiation. However, the metabolic pathways of SPIONs for tissue fusion remain unknown. Hence, the goal ...

2011

Erratum to "Magnetic and in vitro heating properties of implants formed in situ from injectable formulations and containing superparamagnetic iron oxide nanoparticles (SPIONs) embedded in silica microparticles for magnetically induced local hyperthermia" (vol 323, pg 1054, 2011)

Olivier Jordan, Heinrich Hofmann, Alke Fink

2011

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