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Heinrich Hofmann

Cette personne a quitté l’EPFL

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Publications associées (116)

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Systemic Distribution and Elimination of Plain and with Cy3.5 Functionalized Poly(vinyl alcohol) Coated Superparamagnetic Maghemite Nanoparticles After Intraarticular Injection in Sheep In Vivo

Heinrich Hofmann, Alke Fink, Benedikt Steitz

PVA coated and fluorescent dye (Cy3.5) functionalized vinyl alcohol/vinyl amine copolymer coated superparamagnetic iron oxide nanoparticles (SPION) were evaluated for systemic distribution and elimination after intraarticular injection in sheep. Observatio ...

2006

Significance of surface charge and shell material of superparamagnetic iron oxide nanoparticle (SPION) based core/shell nanoparticles on the composition of the protein corona

Heinrich Hofmann, Lionel André Maurizi, Usawadee Sakulkhu, Géraldine Sylvie Coullerez

As nanoparticles (NPs) are increasingly used in many applications their safety and efficient applications in nanomedicine have become concerns. Protein coronas on nanomaterials' surfaces can influence how the cell "recognizes" nanoparticles, as well as the ...

Royal Soc Chemistry2015

Functionalization of iron oxide nanoparticles with methacrylate-based monomers for preparation of nanocomposites

Heinrich Hofmann

Nanocomposites with a high and uniform loading of magnetic nanoparticles are very desirable for various applications. In this study, a simple and scalable route for preparing nanocomposites with a high and uniform loading of magnetic nanoparticles is prese ...

AMER INST PHYSICS2018

Control of morphology and nanostructure of copper and cobalt oxalates: Effect of complexing ions, polymeric additives and molecular weight

Heinrich Hofmann, Paul Bowen, Jacques Lemaître, Alke Fink, Nathalie Jongen

Precipitated oxalates are often nanostructured and can be used as precursors for nanostructured oxides for different applications. The modification of the particle shape and nanostructures of both copper and cobalt oxalates has been demonstrated using poly ...

2010

A thermodynamic model for the precipitation of nanostructured copper oxalates

Heinrich Hofmann, Paul Bowen, Jacques Lemaître, Lucica Soare

A thermodynamic model is developed for the precipitation of copper oxalate from aqueous solutions of copper nitrate and sodium oxalate in a small well-mixed batch reactor. This model is then used to explain the discrepancy between experimental pH evolution ...

2006

Folic acid on iron oxide nanoparticles: platform with high potential for simultaneous targeting, MRI detection and hyperthermia treatment of lymph node metastases of prostate cancer

Heinrich Hofmann, Josefina Adriana Maria Bastiaansen, Marijana Mionic Ebersold, Débora Bonvin

The overexpression of the folate receptor in most cancers has been widely exploited to specifically deliver folic acid (FA) coupled nanomedicines to tumors. However, complex coupling chemistry is often used to bind FA to the nanoparticles. Furthermore, ver ...

Royal Society of Chemistry2017

Effect of cell media on polymer coated superparamagnetic iron oxide nanoparticles (SPIONs): Colloidal stability, cytotoxicity, and cellular uptake studies

Heinrich Hofmann, Alke Fink, Benedikt Steitz, Andrija Finka

The influence of the composition of the polymer coated polyvinyl alcohol (PVA), vinyl alcohol/vinyl amine copolymer (A-PVA) and polyethylenimine (PEI) coated superparamagnetic iron oxide nanoparticles (SPIONs) on the colloidal stability, cytotoxicity and c ...

2008

Magnetic, paramagnetic and/or superparamagnetic nanoparticles

Heinrich Hofmann, Alke Fink, Benedikt Steitz, Andrija Finka

The present invention relates to nanoparticles having a mean diameter of < 500nm and comprising, at their surface, a selected material. The nanoparticles are taken up by cells under physiological conditions and can be used to isolate interaction partners o ...

2009

Visible light optical coherence correlation spectroscopy

Heinrich Hofmann, Theo Lasser, Marcel Leutenegger, Arno Pino Bouwens, Daniel Pawel Szlag, Lionel André Maurizi, Stéphane Broillet

Optical coherence correlation spectroscopy (OCCS) allows studying kinetic processes at the single particle level using the backscattered light of nanoparticles. We extend the possibilities of this technique by increasing its signal-to-noise ratio by a fact ...

Optical Society of America2014

The impact of synthetic amorphous silica (E 551) on differentiated Caco-2 cells, a model for the human intestinal epithelium

Heinrich Hofmann

For several decades, food-grade synthetic amorphous silica (SAS) have been used as a technological additive to reduce caking of food powders. Human exposure is thus inevitable and safety concerns are taken seriously. The toxicity of silica in general and S ...

PERGAMON-ELSEVIER SCIENCE LTD2020

Solder Doped Polycaprolactone Scaffold Enables Solder Doped Polycaprolactone Scaffold Enables. Reproducible Laser Tissue Soldering

Heinrich Hofmann, Alke Fink, Vianney Bernau

During the last 40 years a focus in research was put on sutureless tissue fusion, to handle the limits of conventional suturing such as vascular wall damage due to the enetrating needle, intraluminal foreign body reactions caused by non-absorbable suture m ...

2008

Ceramic particles and layers for functional application

Heinrich Hofmann

Besides 'bulk' structural and functional ceramic, a third interesting group of inorganic or ceramic materials exists: particles used for medical applications like contrast agent as building blocks for photonic crystals, as thin or thick layers with control ...

2009

Enhancement of the efficiency of non-viral gene delivery by application of pulsed magnetic field

Heinrich Hofmann, Alke Fink, Benedikt Steitz

New approaches to increase the efficiency of non-viral gene delivery are still required. Here we report a simple approach that enhances gene delivery using permanent and pulsating magnetic fields. DNA plasmids and novel DNA fragments (PCR products) contain ...

2006

ATP and NADPH coated iron oxide nanoparticles for targeting of highly metabolic tumor cells

Dominique Bonvin, Heinrich Hofmann

The metabolic activity of tumor cells is known to be higher as compared to that of normal cells, which has been previously exploited to deliver nanomedicines to highly metabolic tumor cells. Unfortunately, current strategies, which are mostly based on comp ...

Royal Society of Chemistry2017

Optical properties of annealed Mn2+-doped ZnS nanoparticles

Heinrich Hofmann, Alke Fink, Benedikt Steitz

Cysteine stabilized ZnS and Mn2+-doped ZnS nanoparticles were synthesized by a wet chemical route. Using the ZnS:Mn2+ nanoparticles as seeds, silica-coated ZnS (ZnS@Si) and ZnS:Mn2+ (ZnS:Mn2+@Si) nanocomposites were formed in water by hydrolysis and conden ...

2008

Polymer Adsorption on Iron Oxide Nanoparticles for One-Step Amino-Functionalized Silica Encapsulation

Heinrich Hofmann, Lionel André Maurizi

This paper presents an original method to obtain, in one step, core/shell nanoparticles grafted covalently with polymer and functionalized with amino groups. By combining polyvinyl alcohol (PVA) and silica precursors, we were able to obtain silica-coated a ...

Hindawi Publishing Corporation2015

Versatility of Pyridoxal Phosphate as a Coating of Iron Oxide Nanoparticles

Heinrich Hofmann, Josefina Adriana Maria Bastiaansen, Ulrich Aschauer, Marijana Mionic Ebersold, Débora Bonvin

Pyridoxal 5'-phosphate (PLP) is the most important cofactor of vitamin B-6-dependent enzymes, which catalyses a wide range of essential body functions (e.g., metabolism) that could be exploited to specifically target highly metabolic cells, such as tumour ...

Mdpi Ag2017

Effects of PVA-coated nanoparticles on human T helper cell activity

Heinrich Hofmann, Lionel André Maurizi

Superparamagnetic iron oxide nanoparticles (SPION) are used as high-sensitive enhancer for magnetic resonance imaging, where they represent a promising tool for early diagnosis of destructive diseases such as rheumatoid arthritis (RA). Since we could demon ...

Elsevier2016

The In-Vivo Use of Superparamagnetic Iron Oxide Nanoparticles to Detect Inflammation Elicits a Cytokine Response but Does Not Aggravate Experimental Arthritis

Heinrich Hofmann, Lionel André Maurizi

Background Superparamagnetic Iron Oxide Nanoparticles (SPION) are used in diagnostic imaging of a variety of different diseases. For such in-vivo application, an additional coating with a polymer, for example polyvinyl alcohol (PVA), is needed to stabilize ...

Public Library of Science2015

Nanoparticules à noyau métallique recouvert de silice

Heinrich Hofmann, Alke Fink

The invention relates to nanoparticles based on a metal, on a metal alloy or on a metal derivative coated with a silica layer, in which the silica is crystalline silica, in particular crystalline silica in the cristobalite form. They may be prepared from n ...

2006