Séance de cours

Microscopie électronique : bases et techniques

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Dans cours

MICRO-428: Metrology

The course deals with the concept of measuring in different domains, particularly in the electrical, optical, and microscale domains. The course will end with a perspective on quantum measurements, which could trigger the ultimate revolution in metrology. ...

Description

Cette séance de cours couvre les composantes fondamentales des microscopes électroniques, y compris les sources d'électrons, les lentilles et les détecteurs. Il explique les interactions des électrons avec les échantillons, les principes de travail de SEM, TEM et FIB, et les facteurs influençant la résolution. On discute des avantages de chaque technique, des exigences relatives aux échantillons et des méthodes de préparation. Les modes d'imagerie tels que SE, BS et EDX dans SEM sont expliqués, ainsi que les méthodes de nanofabrication utilisant SEM/FIB. La séance se penche également sur la corrélation entre AFM et SEM et met en valeur des applications comme la tomographie de rigidité et l'imagerie 3D.

Enseignant·e·s (3)

Claudio Bruschini

Claudio Bruschini holds an MSc in high energy physics from the University of Genova and a PhD in Applied Sciences from the Vrije Universiteit Brussel (VUB). He started his career with INFN (Italy, 1993), in the WA92 CERN collaboration (particle physics), and then moved to CERN as a Fellow in the European GP-MIMD2 project, attached to the NA48 collaboration (particle physics, parallel programming, 1994-1995). He then started his close collaboration with EPFL, first in the DeTeC (Demining Technology Center) project (sensors for landmine detection/humanitarian demining, 1996-1997). After DeTeC's end, he started the first of a series of fruitful collaborations with the Vrije Universiteit Brussel (VUB) on humanitarian demining related R&D (1998). This was followed by the EUDEM survey project (The European Union in Humanitarian Demining, 1998), the EUDEM2 three year EC sponsored support measure (www.eudem.info, 2001-2004), and the DELVE support action (www.delve.vub.ac.be, 2007). In parallel he started working within the EPFL's AQUA group (Advanced Quantum Architectures, Edoardo Charbon), on topics as diverse as ultrasonic sensors for in-air application, optical 3D and high speed 2D sensing, sensor networks, or tracking/motion capture systems, in particular for the preparation of research projects. This culminated in the European MEGAFRAME (www.megaframe.eu, FP6, 2006-2010, SPAD arrays and related in-pixel time stamping electronics in deep submicron CMOS technology) and SPADnet (www.spadnet.eu, FP7, 2010-2014, networked SPAD arrays for Positron Emission Tomography) projects, coordinated by EPFL-AQUA. As from 2009 he also worked with Dario Floreano on the management of the CURVACE Curved Artificial Compound Eyes FP7 project (www.curvace.org), coordinated by EPFL-LIS. He was also active with CHUV (Lausanne University Hospital) within EndoTOFPET-US (endoscopic PET) as well as on a CTI project devoted to the development of a new hand-held standalone tool for tracer-guided medical procedures. In 2014 he had also the pleasure of joining the EPFL ICLAB of Christian Enz during its ramp-up phase, collaborating on device related topics (SNF GigaRadMOST) and biomedical R&D (NanoTera WiseSkin). Claudio is now fully with EPFL’s Advanced Quantum Architecture (AQUA). He has also been active as independent scientific consultant, under the label CBR Scientific Consulting, on the preparation of (European) R&D project proposals and the execution of individual studies, and worked in 2006 for a local start-up as operations manager and R&D advisor.... but this is another story. An unauthorized early biography is available at http://lami.epfl.ch/team/claudiob/...

Source officielle

Concepts associés (32)

Corrélation (statistiques)

En probabilités et en statistique, la corrélation entre plusieurs variables aléatoires ou statistiques est une notion de liaison qui contredit leur indépendance. Cette corrélation est très souvent réduite à la corrélation linéaire entre variables quantitatives, c’est-à-dire l’ajustement d’une variable par rapport à l’autre par une relation affine obtenue par régression linéaire. Pour cela, on calcule un coefficient de corrélation linéaire, quotient de leur covariance par le produit de leurs écarts types.

Pearson correlation coefficient

In statistics, the Pearson correlation coefficient (PCC) is a correlation coefficient that measures linear correlation between two sets of data. It is the ratio between the covariance of two variables and the product of their standard deviations; thus, it is essentially a normalized measurement of the covariance, such that the result always has a value between −1 and 1. As with covariance itself, the measure can only reflect a linear correlation of variables, and ignores many other types of relationships or correlations.

Intraclass correlation

In statistics, the intraclass correlation, or the intraclass correlation coefficient (ICC), is a descriptive statistic that can be used when quantitative measurements are made on units that are organized into groups. It describes how strongly units in the same group resemble each other. While it is viewed as a type of correlation, unlike most other correlation measures, it operates on data structured as groups rather than data structured as paired observations.

Transmission electron cryomicroscopy

Transmission electron cryomicroscopy (CryoTEM), commonly known as cryo-EM, is a form of cryogenic electron microscopy, more specifically a type of transmission electron microscopy (TEM) where the sample is studied at cryogenic temperatures (generally liquid-nitrogen temperatures). Cryo-EM is gaining popularity in structural biology. The utility of transmission electron cryomicroscopy stems from the fact that it allows the observation of specimens that have not been stained or fixed in any way, showing them in their native environment.

Correlation coefficient

A correlation coefficient is a numerical measure of some type of correlation, meaning a statistical relationship between two variables. The variables may be two columns of a given data set of observations, often called a sample, or two components of a multivariate random variable with a known distribution. Several types of correlation coefficient exist, each with their own definition and own range of usability and characteristics. They all assume values in the range from −1 to +1, where ±1 indicates the strongest possible agreement and 0 the strongest possible disagreement.

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Séances de cours associées (64)

Composants de microscopie électronique

Couvre les composants du microscope électronique, les systèmes de vide, les aberrations, les détecteurs et les porte-échantillons.

Microscopie électronique : composants et fonctionnement

Explore l'histoire et le fonctionnement des microscopes électroniques, en se concentrant sur les composants et le pouvoir de résolution.

Microscopie électronique : TEM

Explore la microscopie électronique de transmission (TEM), couvrant les modèles de diffraction, la formation d'images et les mécanismes de contraste.

SEM et FIB avancés

Explore les techniques avancées de SEM et la technologie FIB pour l'imagerie et la préparation d'échantillons.

Microscopie électronique à balayage

Explore les principes de la microscopie électronique à balayage, les contrastes de signaux, les facteurs de résolution et les interactions d'échantillons.

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Concepts associés (32)

Corrélation (statistiques)

Pearson correlation coefficient

Intraclass correlation

Transmission electron cryomicroscopy

Correlation coefficient

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