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Publications associées (31)

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Circadian Rhythms and Mitochondria: Connecting the Dots

Carlos Canto Alvarez, Miriam Valera Alberni

Circadian rhythms provide a selective advantage by anticipating organismal nutrient needs and guaranteeing optimal metabolic capacity during active hours. Impairment of circadian rhythms is associated with increased risk of type 2 diabetes and emerging evi ...

FRONTIERS MEDIA SA2018

Circadian clock- and feeding-dependent regulation of translation initiation and elongation in the liver

Cédric Gobet

Circadian rhythms allow organisms to anticipate and adapt to periodic environmental changes related to the day-night cycle. These rhythms originate from a genetic network ticking in almost every cell of our body and the coordination between different organ ...

EPFL2018

Rhythms of the Genome: Circadian Dynamics from Chromatin Topology, Tissue-Specific Gene Expression, to Behavior

Felix Naef, Jake Yeung

Circadian rhythms in physiology and behavior evolved to resonate with daily cycles in the external environment. In mammals, organs orchestrate temporal physiology over the 24-h day, which requires extensive gene expression rhythms targeted to the right tis ...

ELSEVIER SCIENCE LONDON2018

Stem cells and the circadian clock

Benjamin Dieter Weger, Meltem Weger

The circadian timing system is a complex biological network of interacting circadian clocks that regulates 24 h rhythms of behavioral and physiological processes. One intriguing observation is that stem cell homeostasis is subject to circadian clock regula ...

Academic Press Inc Elsevier Science2017

Systems Chronobiology: Global Analysis of Gene Regulation in a 24-Hour Periodic World

Felix Naef, Jake Yeung, Jérôme Mermet

Mammals have evolved an internal timing system, the circadian clock, which synchronizes physiology and behavior to the daily light and dark cycles of the Earth. The master clock, located in the suprachiasmatic nucleus (SCN) of the brain, takes fluctuating ...

Cold Spring Harbor Lab Press, Publications Dept2017

A new promoter element associated with daily time keeping in Drosophila

Felix Naef, Eric Paquet

Circadian clocks are autonomous daily timekeeping mechanisms that allow organisms to adapt to environmental rhythms as well as temporally organize biological functions. Clock-controlled timekeeping involves extensive regulation of rhythmic gene expression. ...

Oxford University Press2017

Transcriptional regulatory logic of the diurnal cycle in the mouse liver

Matteo Dal Peraro, Bart Deplancke, Felix Naef, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger, Sunil Kumar Raghav, Irina Krier, Guillaume Rey, Alexandra Styliani Kalantzi, Jonathan Aryeh Sobel

Many organisms exhibit temporal rhythms in gene expression that propel diurnal cycles in physiology. In the liver of mammals, these rhythms are controlled by transcription-translation feedback loops of the core circadian clock and by feeding-fasting cycles ...

Public Library of Science2017

Rhythmic and clock-dependent chromatin loops regulate circadian gene expression

Jérôme Mermet

In mammals the circadian clock drives daily behavioural and physiological changes that resonate with environmental cues, which can be observed, for example, in the intricate timing of rest during the night and activity during the day in humans. The circadi ...

EPFL2017

Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome

Felix Naef, Carlos Canto Alvarez, Frédéric Bruno Martin Gachon, Loïc Dayon, Daniel Alain Dominique Marie Mauvoisin, Joanna Ratajczak, Jingkui Wang

Lysine acetylation is involved in various biological processes and is considered a key reversible post-translational modification in the regulation of gene expression, enzyme activity, and subcellular localization. This post-translational modification is t ...

Elsevier2017

Rhythmic modulation of transcriptional burst frequency in circadian gene promoters

Damien Lionel Nicolas

Isogenic cells sharing a common environment present a large degree of heterogeneity in gene expression, and stochasticity inherent to transcription substantially participates in this cell-to-cell variability. Notably, a majority of mammalian genes are tran ...

EPFL2017

Regulation of Mammalian Physiology by interconnected Circadian and Feeding Rhythms

Cédric Gobet, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger, Daniel Alain Dominique Marie Mauvoisin

Circadian clocks are endogenous timekeeping systems that adapt in an anticipatory fashion the physiology and behavior of most living organisms. In mammals, the master pacemaker resides in the suprachiasmatic nucleus and entrains peripheral clocks using a w ...

Frontiers Media Sa2017