Prof. Duboule Group

The United of Prof. Duboule laboratory at EPFL, established in 2007, focuses on studying gene regulation during mammalian embryological development, with a special emphasis on Hox genes transcription during axial extension in both in vivo mouse embryos and ES-cells derived pseudo-embryos. The research delves into understanding the regulation and function of Hox genes, crucial for comprehending individual development and evolution. The team uses cutting-edge tools of functional genomics to investigate long-range gene regulation, developmental genes, and mammalian embryos, aiming to unravel the molecular, genetic, and epigenetic mechanisms underlying axial extension.