Prof. Deplancke Group

Laboratory

The Laboratory of Systems Biology and Genetics (LSBG), led by Prof. Deplancke at EPFL, focuses on understanding genome organization, regulation, and variation. The research is divided into three pillars: Adipo, Geno, and Techno. In Adipo, they study mesenchymal stromal cell heterogeneity in adipose biology. Geno investigates how variation in the regulatory code affects diversity. Techno develops novel approaches like microfluidics and high-throughput sequencing. The lab has made significant contributions to the field, such as developing the Live-seq method to track gene activity over time and receiving an Advanced Grant from the Swiss National Science Foundation for the SinPhonies project, aiming to advance single-cell transcriptomics technologies.

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Prof. Deplancke Group

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The dynamic genetic determinants of increased transcriptional divergence in spermatids

Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems

Meeting our Makers: Uncovering the cis-regulatory activity of transposable elements using statistical learning