Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design

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The phenomenon of allostery, a general property in proteins that has been heralded as "the second secret of life" remains elusive to our understanding and even more challenging to incorporate into protein design. One example of allosteric proteins with gre ...

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Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design

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Predicting protein interactions using geometric deep learning on protein surfaces

Investigating the intra-molecular and inter-molecular effects of post-translational modifications on intrinsically disordered protein regions and structured protein regions

A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy

Towards improving full-length ribosome density prediction by bridging sequence and graph-based representations

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From Sequence to Dynamics to Function: Computational Design of Allostery and Ligand Selectivity in G-Protein Coupled Receptors

Microsecond Time-Resolved Cryo-Electron Microscopy

Computational drug development for membrane protein targets

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A new age in protein design empowered by deep learning

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Generative power of a protein language model trained on multiple sequence alignments

Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes

Poloxamers Have Vaccine-Adjuvant Properties by Increasing Dissemination of Particulate Antigen at Distant Lymph Nodes