Publications related to Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems

Related publications (16)

Antibody-based delivery of interleukin-2 modulates the immunosuppressive tumor microenvironment and achieves cure in pancreatic ductal adenocarcinoma syngeneic mice

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and deadly type of cancer, with an extremely low five-year overall survival rate. To date, current treatment options primarily involve various chemotherapies, which often prove ineffecti ...

Springer Science and Business Media LLC2025

Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota

Lucas Pierre Antoine Paoli

Suppression of chronic Arabidopsis immune responses is a widespread but typically strain-specific trait across the major bacterial lineages of the plant microbiota. We show by phylogenetic analysis and in planta associations with representative strains tha ...

NATURE PORTFOLIO2025

A dual-color PAX7 and MYF5 in vivo reporter to investigate muscle stem cell heterogeneity in regeneration and aging

Sara Ancel

Increasing evidence suggests that the muscle stem cell (MuSC) pool is heterogeneous. In particular, a rare subset of PAX7-positive MuSCs that has never expressed the myogenic regulatory factor MYF5 displays unique self-renewal and engraftment characteristi ...

2024

Supplementary files for Machine learning for histological annotation and quantification of cortical layers

Olivier Burri, Julie Meystre

Creators Meystre Julie Olivier Burri Contributors Jean Jacquemier Description This dataset contains 7 QuPath projects. The raw data images linked to these projects and located in other Zenodo datasets need to be downloaded as well. The raw data contains im ...

Zenodo2024

Standardized Production of Anti-Desmoglein 3 Antibody AK23 for Translational Pemphigus Vulgaris Research

Michaël François, Laurence Durrer, Soraya Quinche, Florence Pojer, Kelvin Ka Ching Lau

Antibody-mediated receptor activation is successfully used to develop medical treatments. If the activation induces a pathological response, such antibodies are also excellent tools for defining molecular mechanisms of target receptor malfunction and desig ...

2024

Rational design of small-molecule responsive protein switches

Bruno Emanuel Ferreira De Sousa Correia, Leo Scheller, Sailan Shui, Stephen Michael Buckley

Small-molecule responsive protein switches are powerful tools for controlling cellular processes. These switches are designed to respond rapidly and specifically to their inducer. They have been used in numerous applications, including the regulation of ge ...

2023

Increased prevalence of clonal hematopoiesis of indeterminate potential amongst people living with HIV

Jacques Fellay, Konstantin Popadin, Christian Axel Wandall Thorball

People living with human immunodeficiency virus (PLWH) have significantly increased risk for cardiovascular disease in part due to inflammation and immune dysregulation. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related acquisition an ...

Nature Portfolio2022

c-MAF coordinates enterocyte zonation and nutrient uptake transcriptional programs

Matthias Lütolf, Jakob Josef Langer

c-MAF, highly expressed in villus small intestinal enterocytes, coordinates transcriptional programs for nutrient absorption. Enterocyte-specific c-MAF inactivation impairs dietary lipid handling but also leads to tuft cell expansion and adaptive gut lengt ...

ROCKEFELLER UNIV PRESS2022

Hypoxic Incubation Conditions for Optimized Manufacture of Tenocyte-Based Active Pharmaceutical Ingredients of Homologous Standardized Transplant Products in Tendon Regenerative Medicine

Romain Hamelin, Florence Armand, Diego Chiappe

Human fetal progenitor tenocytes (hFPT) produced in defined cell bank systems have recently been characterized and qualified as potential therapeutic cell sources in tendon regenerative medicine. In view of further developing the manufacture processes of s ...

MDPI2021

Probing the importance of valency and spatial organization of immune regulator PD-1 with DNA-based nanomaterials

Maartje Martina Cornelia Bastings, Alice Comberlato, Cem Tekin, Kaltrina Paloja, Jorieke Weiden

WILEY2021

Clinical trials of mTOR inhibitors to boost immunity to viral infection in older adults

Paula Juricic Dzankic

ELSEVIER2021

The spatial organization of cGAS-TREX1 interactions

Andrea Ablasser, Paula Juricic Dzankic

Coupling DNA sensing to the initiation of immune responses necessitates auxiliary control mechanisms to avoid autoimmunity. A key factor is the exonuclease TREX1, which antagonizes DNA-mediated activation of cGAS. Two studies, by Mohr et al. (2021) and Zho ...

Cell Press - Elsevier2021

TGR5 Regulates Macrophage Inflammation in Nonalcoholic Steatohepatitis by Modulating NLRP3 Inflammasome Activation

Johan Auwerx, Kristina Schoonjans

Nonalcoholic steatohepatitis (NASH) is a chronic liver disease associated with dysregulation of liver metabolism and inflammation. G-protein coupled bile acid receptor 1 (TGR5) is a cell surface receptor that is involved in multiple metabolic pathways. How ...

2021

The circadian oscillator analysed at the single-transcript level

Eric Daniel Jacques Durandau, Felix Naef, Jake Yeung, Damien Lionel Nicolas

The circadian clock is an endogenous and self-sustained oscillator that anticipates daily environmental cycles. While rhythmic gene expression of circadian genes is well-described in populations of cells, the single-cell mRNA dynamics of multiple core cloc ...

2021

Mechanical Immunoengineering of T-cells for Therapeutic Applications

Li Tang, Armand Kurum, Kewen Lei

T cells, a key component in adaptive immunity, are central to many immunotherapeutic modalities aimed at treating various diseases including cancer, infectious diseases, and autoimmune disorders. The past decade has witnessed tremendous progress in immunot ...

American Chemical Society2020

Longitudinal expression changes are weak correlates of disease progression in Huntington's disease

Irina Krier

Huntington's disease is a severe but slowly progressive hereditary illness for which only symptomatic treatments are presently available. Clinical measures of disease progression are somewhat subjective and may require years to detect significant change. T ...

OXFORD UNIV PRESS2020