Publication

The spatial organization of cGAS-TREX1 interactions

Andrea Ablasser, Paula Juricic Dzankic
2021
Journal Articles

Abstract

Coupling DNA sensing to the initiation of immune responses necessitates auxiliary control mechanisms to avoid autoimmunity. A key factor is the exonuclease TREX1, which antagonizes DNA-mediated activation of cGAS. Two studies, by Mohr et al. (2021) and Zhou et al. (2021), uncover new aspects of this important control mechanism.

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The spatial organization of cGAS-TREX1 interactions

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