Mitochondrial ribosomal proteins as aging regulators

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Disruption of mitochondrial function and protein homeostasis plays a central role in aging. However, how these processes interact and what governs their failure in aging remain poorly understood. Here, we showed that cer- amide biosynthesis controls the de ...

BackgroundAging in postmitotic tissues is associated with clonal expansion of somatic mitochondrial deletions, the origin of which is not well understood. Such deletions are often flanked by direct nucleotide repeats, but this alone does not fully explain ...

Aging is characterized by a decline in tissue function, but the underlying changes at cellular resolution across the organism remain unclear. Here, we present the Aging Fly Cell Atlas, a single-nucleus transcriptomic map of the whole aging Drosophila. We c ...

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The mutational spectrum of the mitochondrial DNA (mtDNA) does not resemble any of the known mutational signatures of the nuclear genome and variation in mtDNA mutational spectra between different organisms is still incomprehensible. Since mitochondria are ...

To adapt mitochondrial function to the ever-changing intra- and extracellular environment, multiple mitochondrial stress response (MSR) pathways, including the mitochondrial unfolded protein response (UPRmt), have evolved. However, how the mitochondrial st ...

Organic matter (OM) is a major constituent of fine particulate matter, which contributes significantly to degradation of visibility and radiative forcing, and causes adverse health effects. However, due to its sheer compositional complexity, OM is difficul ...

Loss of mitochondrial function and proteostasis typify aging and age-associated degenerative disorders such as Alzheimer's disease and muscle aging. To date, no cure or preventive measure is available to manage these conditions. Alterations of cellular pro ...

The conceptual evolution of nicotinamide adenine dinucleotide (NAD(+)) from being seen as a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and longevity, including the sirtuin family of protein deacylases, has led to ...

Mutations in nuclear-encoded mitochondrial genes are responsible for a broad spectrum of disorders among which Leigh syndrome is the most common in infancy. No effective therapies are available for this severe disease mainly because of the limited capabili ...

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Modern biology rapidly generates a wealth of data,which can only be analysed computationally.Despite the variety of available data types,most of them aim to provide an answer to one question: how does genotypic diversity translates into phenotypes? This qu ...

The evolutionarily conserved nature of the few well-known anti-aging interventions that affect lifespan, such as caloric restriction, suggests that aging-related research in model organisms is directly relevant to human aging. Since human lifespan is a com ...

An increasing aging population poses a significant challenge to societies worldwide. A better understanding of the molecular, cellular, organ, tissue, physiological, psychological, and even sociological changes that occur with aging is needed in order to t ...

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Autophagy is a highly conserved process by which long-lived macromolecules, protein aggregates and dysfunctional/damaged organelles are delivered to lysosomes for degradation. Autophagy plays a crucial role in regulating protein quality control and cell ho ...

Mitochondrial ribosomal proteins as aging regulators

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Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging

Secondary structure of the human mitochondrial genome affects formation of deletions

Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution

Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice

Detecting the metabolism of individual yeast mutant strain cells when aged, stressed or treated with antioxidants with diamond magnetometry

Predictive health assessment for lithium-ion batteries with probabilistic degradation prediction and accelerating aging detection

Mitophagy Activation by Urolithin A to Target Muscle Aging

A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

Estimating mean molecular weight, carbon number, and OM∕OC with mid-infrared spectroscopy in organic particulate matter samples from a monitoring network

Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease

NAD(+) homeostasis in health and disease

Gene replacement therapy provides benefit in an adult mouse model of Leigh syndrome

Metabolic rescue of muscle and muscle stem cells in muscle disease

Gamified Motor Training With Tangible Robots in Older Adults: A Feasibility Study and Comparison With the Young

Multi-omics reveals abundant mitochondrial genomic and circadian expression variation in the Drosophila Genetic Reference Panel

Cross-species functional modules link proteostasis to human normal aging

Latest advances in aging research and drug discovery

Calorie restriction slows age-related microbiota changes in an Alzheimer's disease model in female mice

Autophagy and LRRK2 in the Aging Brain