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Mitochondrial ribosomal proteins as aging regulators

Related publications (31)

Autophagy and LRRK2 in the Aging Brain

Autophagy is a highly conserved process by which long-lived macromolecules, protein aggregates and dysfunctional/damaged organelles are delivered to lysosomes for degradation. Autophagy plays a crucial role in regulating protein quality control and cell ho ...

FRONTIERS MEDIA SA2019

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

Bernard Schneider, Graham Knott, Kristina Schoonjans, Johan Auwerx, Adrienne Joëlle Laurence Mottis, Vera Monica Lemos Da Silva, Hao Li, Vincenzo Sorrentino, Davide D'Amico, Mario Romani, Francesca Potenza

Little information is available about how post-transcriptional mechanisms regulate the aging process. Here, we show that the RNA-binding protein Pumilio2 (PUM2), which is a translation repressor, is induced upon aging and acts as a negative regulator of li ...

CELL PRESS2019

Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors

Patrick Descombes, Guillaume Jacot, Sara Ancel, Laura Lukjanenko, Sylviane Métairon, Sonia Karaz, Federico Sizzano, Omid Mashinchian

Research on age-related regenerative failure of skeletal muscle has extensively focused on the phenotypes of muscle stem cells (MuSCs). In contrast, the impact of aging on regulatory cells in the MuSC niche remains largely unexplored. Here, we demonstrate ...

CELL PRESS2019

MicroRNA-382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells

Johan Auwerx, Norman Lionel Moullan, Pénélope Andreux, Xu Wang

Proper mitochondrial function plays a central role in cellular metabolism. Various diseases as well as aging are associated with diminished mitochondrial function. Previously, we identified 19 miRNAs putatively involved in the regulation of mitochondrial m ...

2019

Yearlong variability of oxidative potential of particulate matter in an urban Mediterranean environment

Athanasios Nenes

The oxidative potential (OP) of fine and coarse fractions of ambient aerosols was studied in the urban environment of Athens, Greece. OP was quantified using a dithiothreitol (DTT) assay, applied to the water soluble fraction of aerosol that was extracted ...

Elsevier2019

Evolution of longevity improves immunity in Drosophila

Bruno Lemaitre

Much has been learned about the genetics of aging from studies in model organisms, but still little is known about naturally occurring alleles that contribute to variation in longevity. For example, analysis of mutants and transgenes has identified insulin ...

JOHN WILEY & SONS LTD2018

Erythrocyte's aging in microgravity highlights how environmental stimuli shape metabolism and morphology

Giovanni Dietler, Giovanni Longo

The determination of the function of cells in zero-gravity conditions is a subject of interest in many different research fields. Due to their metabolic unicity, the characterization of the behaviour of erythrocytes maintained in prolonged microgravity con ...

Nature Research2018

Multi-factorial approach in aging research

Michael Herzog, Aaron Michael Clarke, Albulena Jashari-Shaqiri

Aging affects all kinds of human functions including perception and cognition. In most perceptual studies, one paradigm is tested and it is usually found that older participants perform worse than younger participants. Implicitly, these results are taken a ...

2017

Multi-factorial approach in aging research

Michael Herzog, Aaron Michael Clarke, Albulena Jashari-Shaqiri

The developed world is aging faster than ever before. Even in the absence of neurodegenerative disease, aging affects all kinds of human functions including perception and cognition. In most perceptual studies, one paradigm is tested and it is usually foun ...

2017

Modulating NAD(+) metabolism, from bench to bedside

Elena Katsyuba, Johan Auwerx

Discovered in the beginning of the 20(th) century, nicotinamide adenine dinucleotide (NAD(+)) has evolved from a simple oxidoreductase cofactor to being an essential cosubstrate for a wide range of regulatory proteins that include the sirtuin family of NAD ...

Wiley2017

Predicting the Success of Online Petitions Leveraging Multidimensional Time-Series

Philippe Cudré-Mauroux, Karl Aberer, Julia Proskurnia, Carlos Castillo

Applying classical time-series analysis techniques to online content is challenging, as web data tends to have data quality issues and is often incomplete, noisy, or poorly aligned. In this paper, we tackle the problem of predicting the evolution of a time ...