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Dina Hofer

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Related publications (4)

Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.

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Related publications (4)

Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.

Mitochondrial and NAD plus metabolism predict recovery from acute kidney injury in a diverse mouse population

Johan Auwerx, Maroun Bou Sleiman, Yang Li, Jean-David Horacio Morel, Giacomo Vincenzo Giorgio Von Alvensleben, Alexis Maximilien Bachmann, Dina Hofer

Acute kidney failure and chronic kidney disease are global health issues steadily rising in incidence and prevalence. Animal models on a single genetic background have so far failed to recapitulate the clinical presentation of human nephropathies. Here, we ...

AMER SOC CLINICAL INVESTIGATION INC2023

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

Johan Auwerx, Dina Hofer

N-acetylaspartate (NAA) is synthesized by aspartate N-acetyltransferase (gene: Nat8l) from acetyl-coenzyme A and aspartate. In the brain, NAA is considered an important energy metabolite for lipid synthesis. However, the role of NAA in peripheral tissues r ...

2019

NAD(+) homeostasis in health and disease

Johan Auwerx, Elena Katsyuba, Mario Romani, Dina Hofer

The conceptual evolution of nicotinamide adenine dinucleotide (NAD(+)) from being seen as a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and longevity, including the sirtuin family of protein deacylases, has led to ...

2020