MEMS tools for combinatorial materials processing and high-throughput characterization

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The present invention concerns a bodily implantable or probe device and microelectrode fabrication method comprising providing at least one silicon substrate including an electronic device or unit; providing, on a first side of the silicon substrate, at le ...

Macrocycles provide an attractive modality for drug development but the identification of ligands to targets of interest is hindered by the lack of large macrocyclic compound libraries for high-throughput screening. A strategy to efficiently synthesize lar ...

There is described a mouthguard comprising an externally exposed impact protective region defined by a first material property and configured to cover a front tooth, an internally exposed occlusional cushioning region defined by a second material property ...

The invention provides microfluidic screening systems for the identification of compounds or compositions influencing cellular transcriptomes. The invention is predicated upon taking into account differences in newly synthesized mRNA in contrast to so call ...

Surface-based inflatables are composed of two thin layers of nearly inextensible sheet material joined together along carefully selected fusing curves. During inflation, pressure forces separate the two sheets to maximize the enclosed volume. The fusing c ...

Several boreholes were drilled for site comparison of a deep geological repository (DGR) in Northern Switzerland. The main target of the exploration program was the >100m thick Opalinus Clay, the designated host rock encountered at approximately 450 to 100 ...

Newer solid-phase peptide synthesis and release strategies enable the production of short peptides with high purity, allowing direct screening for desired bioactivity without prior chromatographic purification. However, the maximum number of peptides that ...

When two objects slide against each other, wear and friction occur at their interface. The accumulation of wear forms what is commonly referred to as a ``third-body''. Understanding third-body evolution has significant applications in industry, where contr ...

The different receptors in human skin show not only diversity in the stimuli to which they respond, but also variable sensitivity and directionality. This is often determined by their location or morphology, and can play an important role in filtering or a ...

Most codes of practice adopt a semi probabilistic design approach for the dimensioning and assessment of structures. Accordingly, structural safety is ensured by performing limit state verifications using design values determined with adequately calibrated ...

Background In contact sports, an impact on the jaw can generate destructive stress on the tooth-bone system. Mouthguards can be beneficial in reducing the injury risk by changing the dynamics of the trauma. The material properties of mouthguards and their ...

Silicon heterojunction (SHJ)-solar modules-when encapsulated with ethylene vinyl acetate (EVA)-are known to be extremely sensitive to water ingress. The reason for this is, however, not clear. Here, we explain the root causes of this degradation mechanism ...

A large part of building demolitions is motivated by purely socio-economic reasons. Hence, about-to-be-demolished structures, commonly made of reinforced concrete, very often present no or little degradation. When adaptive reuse of the entire building is n ...

Mitochondria are essential organelles participating in numerous cellular functions, including energy harvesting, regulation of homeostasis and apoptosis. Changes in mitochondrial number, morphology, and function not only impact cellular metabolism but also ...

With growing awareness of the vulnerability of the near-Earth space region and the anticipated surge in satellite objects, efforts are underway to assess and implement various mitigation strategies. These aim to minimize the impact of space activities and ...

Examining the performance of an existing bridge requires information on several aspects, such as design choices, material properties, and ongoing degradation processes. It often happens that some critical information is not available. The traditional appro ...

The ability to control high-voltage actuator arrays relies, to date, on expensive microelectronic processes or on individual wiring of each actuator to a single off-chip high-voltage switch. Here we present an alternative approach that uses on-chip photoco ...

Strain is an inevitable phenomenon in two-dimensional (2D) material, regardless of whether the film is suspended or supported. Moreover, strain is known to alter the physical and chemical properties, such as the band gap, charge carrier effective masses, d ...

Genetic and cellular drivers of the cellular uptake of SARS-CoV-2 can be screened at high throughput via droplet microfluidics and size-exclusion methods for the analysis of the formation of fusions between cells expressing the virus's spike protein and ce ...

The vibrational response of solid materials and structural components is substantially governed by their mechanical and geometrical properties. Low-frequency vibrations and modal frequencies are sensitive to global geometrical deviations, while high-freque ...

MEMS tools for combinatorial materials processing and high-throughput characterization

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Bodily implant microelectrode and bodily implant microelectrode fabrication method

Methods for high-throughput synthesis and screening of peptide libraries

Customized modular multi-material mouthguard and method of making the same

Improved microfluidic transcriptome based screening methods

Computational Homogenization for Inverse Design of Surface-based Inflatables

Insights from an extensive triaxial testing campaign on a shale for comparative site characterization of a deep geological repository

Solid-phase peptide synthesis in 384-well plates

Modeling friction and wear using an adaptive discrete-continuum coupling

Morphological and Material Programability of a Hall-Effect Based Soft Tactile Sensors

Influence of model uncertainty and long term deformations in action effects calculation in reinforced concrete structures

Design of Customized Mouthguards with Superior Protection Using Digital-Based Technologies and Impact Tests

A comprehensive physical model for the sensitivity of silicon heterojunction photovoltaic modules to water ingress

Reusability assessment of reinforced concrete components prior to deconstruction from obsolete buildings

Drug Screening in C. elegans to identify new pharmacological mitochondrial stress inducers

Design for demise applied to spacecraft structural panels and experiments for ClearSpace One platform

A global framework for data-informed bridge examination

Dynamic control of high-voltage actuator arrays by light-pattern projection on photoconductive switches

Atomic-scale Characterization of Strain and Gate effects on Two-dimensional Materials by Scanning Tunneling Microscopy

Screening for drivers of SARS-CoV-2 uptake

Vibrational NDT with Under-sampled Data through Physics-informed Neural Networks