Publication

Improved microfluidic transcriptome based screening methods

Christoph Merten, Leonie Kolmar, Xiaoli Ma, Hongxing Hu
2024
Patents

Abstract

The invention provides microfluidic screening systems for the identification of compounds or compositions influencing cellular transcriptomes. The invention is predicated upon taking into account differences in newly synthesized mRNA in contrast to so called old mRNA and such differences compared to control cell assays. The invention is applicable for screening in particular candidate ligand molecules such as antibodies for an effect on target cells, and thereby provides new strategies for the identification of therapeutically active compounds.

Official source

https://infoscience.epfl.ch/entities/publication/bfa519c0-6aa8-401b-ba9e-19f33d901f54

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Improved microfluidic transcriptome based screening methods

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