The journey of resveratrol from yeast to human

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Aging is characterized by a decline in tissue function, but the underlying changes at cellular resolution across the organism remain unclear. Here, we present the Aging Fly Cell Atlas, a single-nucleus transcriptomic map of the whole aging Drosophila. We c ...

Disruption of mitochondrial function and protein homeostasis plays a central role in aging. However, how these processes interact and what governs their failure in aging remain poorly understood. Here, we showed that cer- amide biosynthesis controls the de ...

Objective This study explored the impact of time-restricted eating (TRE) versus standard dietary advice (SDA) on bone health. Methods Adults with >= 1 component of metabolic syndrome were randomized to TRE (ad libitum eating within 12 hours) or SDA (food p ...

The present invention relates to an inhibitor of sphingolipids for use in the treatment or prevention of an aging related-disease and/or aging. ...

Weight loss is key to controlling the increasing prevalence of metabolic syndrome (MS) and its components, i.e., central obesity, hypertension, prediabetes and dyslipidaemia. The goals of our study were two-fold. First, we characterised the relationships b ...

Increasing interest in understanding fundamental biological processes, among which aging and nutrition, has led to the study of simple and powerful model organisms, as the round-worm Caenorhabditis elegans (C. elegans). The nematode, selected by Sydney Bre ...

Loss of mitochondrial function and proteostasis typify aging and age-associated degenerative disorders such as Alzheimer's disease and muscle aging. To date, no cure or preventive measure is available to manage these conditions. Alterations of cellular pro ...

The conceptual evolution of nicotinamide adenine dinucleotide (NAD(+)) from being seen as a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and longevity, including the sirtuin family of protein deacylases, has led to ...

Mitochondrial dysfunction is associated with aging-mediated inflammatory responses, leading to metabolic deterioration, development of insulin resistance, and type 2 diabetes. Growth differentiation factor 15 (GDF15) is an important mitokine generated in r ...

Alzheimer's disease (AD) affects an estimated 5.8 million Americans, and advanced age is the greatest risk factor. AD patients have altered intestinal microbiota. Accordingly, depleting intestinal microbiota in AD animal models reduces amyloid-beta (A beta ...

The evolutionarily conserved nature of the few well-known anti-aging interventions that affect lifespan, such as caloric restriction, suggests that aging-related research in model organisms is directly relevant to human aging. Since human lifespan is a com ...

An increasing aging population poses a significant challenge to societies worldwide. A better understanding of the molecular, cellular, organ, tissue, physiological, psychological, and even sociological changes that occur with aging is needed in order to t ...

The adipose tissue is increasingly recognized for the important role it plays in various diseases and pathological conditions, such as obesity, diabetes, cardiovascular diseases, osteoporosis, cancer, and aging. Despite its long-held reputation for being a ...

Metabolic syndrome and diabetes impact brain function and metabolism. While it is well established that rodents exposed to diets rich in saturated fat develop brain dysfunction, contrasting results abound in the literature, likely as result of exposure to ...

Aging affects all kinds of human functions including perception and cognition. In most perceptual studies, one paradigm is tested and it is usually found that older participants perform worse than younger participants. Implicitly, these results are taken a ...

Discovered in the beginning of the 20(th) century, nicotinamide adenine dinucleotide (NAD(+)) has evolved from a simple oxidoreductase cofactor to being an essential cosubstrate for a wide range of regulatory proteins that include the sirtuin family of NAD ...

The developed world is aging faster than ever before. Even in the absence of neurodegenerative disease, aging affects all kinds of human functions including perception and cognition. In most perceptual studies, one paradigm is tested and it is usually foun ...

Ectopic lipid accumulation in the liver is implicated in metabolic disease in an age- and sex-dependent manner. The role of hepatic lipids has been well established within the scope of metabolic insults in mice, but has been insufficiently characterized un ...

The microbiome has been demonstrated to play an integral role in the maintenance of many aspects of health that are also associated with aging. In order to identify areas of potential exploration and intervention, we simultaneously characterized age-relate ...

The mechanical properties of Fe-Mn-Al-C steel are significantly enhanced after κ-carbide precipitation via aging; however, most aging treatments are energy demanding because they require relatively high temperatures and extended holding times. This researc ...

The journey of resveratrol from yeast to human

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Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution

Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging

The effects of time-restricted eating and weight loss on bone metabolism and health: a 6-month randomized controlled trial

Treatment and prevention of aging related-disease and/or aging by the inhibition of sphingolipids

The Effects of Time-Restricted Eating versus Standard Dietary Advice on Weight, Metabolic Health and the Consumption of Processed Food: A Pragmatic Randomised Controlled Trial in Community-Based Adults

Microfluidic culture platforms for C. elegans bacterial interaction and digestion studies at single-organism resolution

Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease

NAD(+) homeostasis in health and disease

Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice

Calorie restriction slows age-related microbiota changes in an Alzheimer's disease model in female mice

Cross-species functional modules link proteostasis to human normal aging

Latest advances in aging research and drug discovery

The role of the transcriptional regulator BCL6 in adipose tissue development and remodeling

Neurochemical Modifications in the Hippocampus, Cortex and Hypothalamus of Mice Exposed to Long-Term High-Fat Diet

Multi-factorial approach in aging research

Modulating NAD(+) metabolism, from bench to bedside

Multi-factorial approach in aging research

Sexual dimorphism in hepatic lipids is associated with the evolution of metabolic status in mice

Aging and sarcopenia associate with specific interactions between gut microbes, serum biomarkers and host physiology in rats

Hot deformation of a Fe-Mn-Al-C steel susceptible of κ-carbide precipitation