The journey of resveratrol from yeast to human

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Discovered in the beginning of the 20th century, nicotinamide adenine dinucleotide (NAD+) has evolved from a simple oxidoreductase cofactor to being an essential cosubstrate for a wide range of regulatory proteins that include most notoriously the sirtuin ...

Objective: Augmenting nicotinamide adenine dinucleotide (NAD(+)) availability may protect skeletal muscle from age-related metabolic decline. Dietary supplementation of NAD(+) precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) appe ...

Age-associated changes in chromatin structure have a major impact on organismal longevity. Despite being a central part of the ageing process, the organismal responses to the changes in chromatin organization remain unclear. Here we show that moderate dist ...

Caloric restriction (CR) has been shown to prevent the onset of insulin resistance and to delay age-related physiological decline in mammalian organisms. SIRT1, a NAD(+) -dependent deacetylase enzyme, has been suggested to mediate the adaptive responses to ...

Even in the absence of neurodegenerative disease, aging strongly affects vision. Whereas optical deficits are well documented, much less is known perceptual deficits. In most perceptual studies, one paradigm is tested and it is usually found that older par ...

The biological effects of urolithins remain poorly characterized, despite wide-spread human exposure via the dietary consumption of their metabolic precursors, the ellagitannins, which are found in the pomegranate fruit, as well as in nuts and berries. We ...

The developed world is aging faster than ever before. Even in the absence of neurodegenerative disease, aging affects all kinds of human functions including perception and cognition. In most perceptual studies, one paradigm is tested and it is usually foun ...

Studies of the real-time dynamics of embryonic development require a gentle embryo handling method, the possibility of long-term live imaging during the complete embryogenesis, as well as of parallelization providing a population's statistics, while keepin ...

Ageing affects many visual functions. Here, we investigated the effects of ageing on vernier acuity and backward masking using the shine-through paradigm. We divided healthy older adults (> 60 years) into two groups depending on whether vernier duration wa ...

As centenarians well represent the model of healthy aging, there are many important implications in revealing the underlying molecular mechanisms behind such successful aging. By combining NMR metabonomics and shot-gun lipidomics in serum we analyzed metab ...

The journey of resveratrol from yeast to human

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Role of ACMSD in regulation of NAD+ metabolism and mitochondrial function

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells

The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress

SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent Fasting

Is there a common cause for perceptual decline in the aging brain?

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

The effects of aging on perception and cognition

Aging and perception

An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging

Ageing and visual spatiotemporal processing

Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity