Interference of silver nanoparticles with essential metal homeostasis in a novel enterohepatic fish in vitro system

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Solvent resistant and pH-stable nanofiltration membranes play a crucial role in solvent or water reuse across various industries, including pharma, chemical, dairy and mining, where stringent pH conditions and chemical stability are imperative. Previous re ...

The ultimate thinness of graphene pores makes them ideal as a high-flux selective layer for manipulating molecular transport. However, due to the limited understanding of the formation of ångstrom (Å)-scale pores, controlling pore size and understanding ga ...

Efferocytosis, the efficient clearance of apoptotic cells (ACs) by phagocytes, is vital for maintaining tissue homeostasis. Here, we reveal the role of the secreted protein NimB1 in reducing apoptotic cell recognition and binding in the early stages of eff ...

Background & Aims: Current therapies for the treatment of alcohol-related liver disease (ALD) have proven largely ineffective. Patients relapse and the disease progresses even after liver transplantation. Altered epigenetic mechanisms are characteristic of ...

Background Excessive inflammation, hemolysis, and accumulation of labile heme play an essential role in the pathophysiology of multi-organ dysfunction syndrome (MODS) in sepsis. Alpha1-antitrypsin (AAT), an acute phase protein with heme binding capacity, i ...

In this issue of Cell, Nie and co-authors report that the microbe-derived bile acid (BA) 3-succinylated cholic acid protects against the progression of metabolic dysfunction-associated liver disease. Intriguingly, its protective mechanism does not involve ...

Breast cancer (BC) is the most diagnosed cancer and a leading cause of cancer-related mortality for women worldwide (Bray Bsc et al. 2024). It is a heterogeneous disease with 19 special histopathological subtypes and 5 molecular subtypes (Tavassoli and Dev ...

Introduction: Glaucoma, the leading cause of irreversible blindness globally, affects more than 70 million people across the world. When initial treatments prove ineffective, especially for cases with high intraocular pressure (IOP), the preferred approach ...

The natural compound Cyclo Histidine-Proline (CHP) was initially discovered in the brain, but thereafter evaluated in the context of diabetes because of its hypoglycemic action. The pharmacokinetics and the toxicological profile of CHP showed it can be dos ...

A simple predictive biomarker for fatty liver disease is required for individuals with insulin resistance. Here, we developed a supervised machine learning-based classifier for fatty liver disease using fecal 16S rDNA sequencing data. Based on the Kangbuk ...

Brain edema is considered as a common feature associated with hepatic encephalopathy (HE). However, its central role as cause or consequence of HE and its implication in the development of the neurological alterations linked to HE are still under debate. I ...

Transporters of the SLC25 mitochondrial carrier superfamily bridge cytoplasmic and mitochondrial metabolism by channeling metabolites across mitochondrial membranes and are pivotal for metabolic homeostasis. Despite their physiological relevance as gatekee ...

Background: There is increasing evidence that children or young adults having acquired liver disease in childhood display neurocognitive impairment which may become more apparent as they grow older. The molecular, cellular and morphological underpinnings o ...

Oxidative stress is a natural phenomenon in the body. Under physiological conditions intracellular reactive oxygen species (ROS) are normal components of signal transduction cascades, and their levels are maintained by a complex antioxidants systems partic ...

Type C hepatic encephalopathy (HE) is a severe neuropsychiatric complication of chronic liver disease, for which the prognosis is poor in the absence of liver transplantation. Cirrhosis in type C HE leads to a toxic accumulation of ammonia in the blood, wh ...

BSEP (ABCB11) is an ATP-binding cassette transporter that is expressed in hepatocytes and extrudes bile salts into the canaliculi of the liver. BSEP dysfunction, caused by mutations or induced by drugs, is frequently associated with severe cholestatic live ...

In eukaryotes, RNA is synthesised in the nucleus, spliced, and exported to the cytoplasm where it is translated and finally degraded. Any of these steps could be subject to temporal regulation during the circadian cycle, resulting in daily fluctuations of ...

The control of the aggregation of biomedical nanoparticles (NP) in physiological conditions is crucial as clustering may change completely the way they interact with the biological environment. Here we show that Au nanoparticles, functionalized by an anion ...

Disruption of mitochondrial function and protein homeostasis plays a central role in aging. However, how these processes interact and what governs their failure in aging remain poorly understood. Here, we showed that cer- amide biosynthesis controls the de ...

Cell-based drug carriers present an interesting approach to improve the targeted delivery of therapeutic drugs in vivo. Specifically, bacterial cells possess interesting properties such as motility and sensing that allow some strains to selectively target ...

Interference of silver nanoparticles with essential metal homeostasis in a novel enterohepatic fish in vitro system

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Stereochemical tuning, post-synthesis crosslinking and quaternizing to tune the membrane performance of ultra-stable polyamine nanofiltration membranes

A holistic approach for incorporating sub-angstrom gas-sieving pores in single-layer graphene: from atomic simulations to large area membranes

The secreted Nimrod protein NimB1 negatively regulates early steps of apoptotic cell phagocytosis in Drosophila

Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1

Alpha1-antitrypsin improves survival in murine abdominal sepsis model by decreasing inflammation and sequestration of free heme

A microbial-derived succinylated bile acid to safeguard liver health

ER+ breast cancer in 3D scaffold ex vivo for transcriptomics-based functional drug screening and personalized medicine

A new self-adjustable glaucoma valve

Characterization of Cyclo His-Pro for the prevention and treatment of liver disease and muscular dystrophy

Machine learning-derived gut microbiome signature predicts fatty liver disease in the presence of insulin resistance

Lessons on brain edema in HE: from cellular to animal models and clinical studies

Dissecting the role of the mitochondrial carrier SLC25A47

High field brain proton magnetic resonance spectroscopy and volumetry in children with chronic, compensated liver disease-A pilot study

Overview of oxidative stress findings in hepatic encephalopathy: From cellular and ammonium-based animal models to human data

New insights into rodent brain microstructure and metabolism in hepatic encephalopathy

Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP

Comprehensive analysis of the circadian nuclear and cytoplasmic transcriptome in mouse liver

Ion-bridges and lipids drive aggregation of same-charge nanoparticles on lipid membranes

Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging

Preparation and Analysis of Bacteria Surface-Modified with Polymer Nanoparticles