Intracellular recording of cardiomyocyte action potentials with nanopatterned volcano-shaped microelectrodes

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Anion exchange membrane water electrolysis (AEMWE) offers a green hydrogen production method that eliminates the need for platinum group metals (PGM) as electrocatalysts. This study employs a COMSOL (R) 6.0 model to simulate a 1x1 cm(2) Ni fibre - Raney (R ...

Subcortical brain structures such as the basal ganglia or the thalamus are involved in regulating motor and cognitive behavior. However, their contribution to perceptual consciousness is still unclear, due to the inherent difficulties of recording subcorti ...

Macrocycles offer an attractive format for drug development due to their good binding properties and potential to cross cell membranes. To efficiently identify macrocyclic ligands for new targets, methods for the synthesis and screening of large combinator ...

Neural decoding of the visual system is a subject of research interest, both to understand how the visual system works and to be able to use this knowledge in areas, such as computer vision or brain-computer interfaces. Spike-based decoding is often used, ...

The remarkable adaptability observed in marine ecosystems has often inspired researchers when developing new soft materials. The research undertaken in this thesis explores how ion chelator pair interactions influence the mechanical properties of bioinspir ...

The present invention concerns a bodily implantable or probe device and microelectrode fabrication method comprising providing at least one silicon substrate including an electronic device or unit; providing, on a first side of the silicon substrate, at le ...

Recordings of the physiological history of cells provide insights into biological processes, yet obtaining such recordings is a challenge. To address this, we introduce a method to record transient cellular events for later analysis. We designed proteins t ...

Transmembrane protein 16 F (TMEM16F) is a Ca2+-activated homodimer which functions as an ion channel and a phospholipid scramblase. Despite the availability of several TMEM16F cryogenic electron microscopy (cryo-EM) structures, the mechanism of activation ...

Background/Objectives: Biological products are emerging as therapeutic management options for intervertebral disc (IVD) degenerative affections and lower back pain. Autologous and allogeneic cell therapy protocols have been clinically implemented for IVD r ...

This thesis presents an extensive exploration of neuroelectronic interfaces, focusing on microfabrication, in silico modeling, and their applications in designing and fabricating devices for neural interfacing. The research encompasses both peripheral nerv ...

Social behaviors such as cooperation are crucial for mammals. A deeper knowledge of the neuronal mechanisms underlying cooperation can be beneficial for people suffering from pathologies with impaired social behavior. Our aim was to study the brain activit ...

Electrical stimulation of the visual nervous system could improve the quality of life of patients affected by acquired blindness by restoring some visual sensations, but requires careful optimization of stimulation parameters to produce useful perceptions. ...

This thesis focuses on developing microfluidic systems using dielectrophoresis (DEP) to manipulate and isolate biological species. It presents several innovations in electrokinetic systems, including a device for pairing cells with minimal loss during enca ...

Traditionally, studies in schizophrenia research employ a single experimental paradigm. The results typically demonstrate a significant difference between patients and controls. Subsequent studies aim to describe the underlying abnormal mechanism at the ge ...

In the field of electrochemical CO2 reduction, both continuum models and molecular dynamics (MD) models have been used to understand the electric double layer (EDL). MD often focuses on the region within a few nm of the electrode, while continuum models ca ...

Before the COVID-19 pandemic, viruses were not a major priority for the scientific community. Today, many events have changed the world and the importance of studying viruses, vaccines, and antiviral drugs is fully appreciated. The development of effective ...

Endoplasmic reticulum (ER) retention of misfolded glycoproteins is mediated by the ER-localized eukaryotic glycoprotein secretion checkpoint, UDP-glucose glycoprotein glucosyl-transferase (UGGT). The enzyme recognizes a misfolded glycoprotein and flags it ...

The application of computational biology in drug development for membrane protein targets has experienced a boost from recent developments in deep learning-driven structure prediction, increased speed and resolution of structure elucidation, machine learni ...

Atomic force microscopy (AFM) is a widely used imaging tool for obtaining a variety of information for a range of samples. Although it was initially intended to serve as a method of observing very flat solid surfaces, its use expanded into several other fi ...

Neocortical neurons can increasingly be divided into well-defined classes, but their activity patterns during quantified behavior remain to be fully determined. Here, we obtained membrane potential recordings from various classes of excitatory and inhibito ...

Intracellular recording of cardiomyocyte action potentials with nanopatterned volcano-shaped microelectrodes

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Membrane electrode assembly simulation of anion exchange membrane water electrolysis

Subcortical correlates of consciousness with human single neuron recordings

Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation

Predicting Visual Stimuli From Cortical Response Recorded With Wide-Field Imaging in a Mouse

From Surfactants to 3D Printing: How Ion-Chelator Pair Interactions Affect the Mechanical Properties of Bioinspired Materials

Bodily implant microelectrode and bodily implant microelectrode fabrication method

Recording physiological history of cells with chemical labeling

Structural heterogeneity of the ion and lipid channel TMEM16F

Banked Primary Progenitor Cells for Allogeneic Intervertebral Disc (IVD) Therapy: Preclinical Qualification and Functional Optimization within a Cell Spheroid Formulation Process

Modeling, fabrication and validation of 3D neural interfaces for peripheral nerves and brain organoids

Involvement of prelimbic cortex neurons and related circuits in the acquisition of a cooperative learning by pairs of rats

Decoding electroencephalographic responses to visual stimuli compatible with electrical stimulation

Dielectrophoretic Manipulation of Biological Species: Novel Microfluidic Approaches to Study Cell-Cell Interactions and the Role of Alpha-Synuclein in Neurodegeneration

Variability is the rule: Neurophysiology and contextual visual processing in schizophrenia

Contrasting Views of the Electric Double Layer in Electrochemical CO2 Reduction: Continuum Models vs Molecular Dynamics

Peptide-based virucidal drugs

Rescue of secretion of rare-disease-associated misfolded mutant glycoproteins in UGGT1 knock-out mammalian cells

Computational drug development for membrane protein targets

Advancements in Nanomechanical Characterization and Biomolecular Imaging with Atomic force Microscopy

Membrane potential dynamics of excitatory and inhibitory neurons in mouse barrel cortex during active whisker sensing