Publications by Mahmut Selman Sakar

Related publications (47)

A model for cellular mechanotransduction and contractility at finite strain

William Curtin, Mahmut Selman Sakar, Nikolaos Bouklas

In this work we introduce a theoretical and computational modeling framework for the contractile response of single cells triggered by external mechanical stimuli. The structural response due to the formation and dissociation of stress fibers is modeled fo ...

2018

A model for cellular mechanotransduction and contractility at finite strain

William Curtin, Mahmut Selman Sakar, Nikolaos Bouklas

In this work we introduce a theoretical and computational modeling framework for the contractile response of single cells triggered by external mechanical stimuli. The structural response due to the formation and dissociation of stress fibers is modeled fo ...

2018

Acoustic Levitation apparatus (Robotics Practicals)

Mahmut Selman Sakar, Amit Yedidia Dolev, Lorenzo Francesco John Noseda, Bora Yalcin

The following data contain the information and files, which are required to recreate and build the experimental setup that is described in the Laboratory manual. Further details can be found in the associated publication “A graduate laboratory experiment t ...

Zenodo2023

Microengineered devices enable long-term imaging of the ventral nerve cord in behaving adult Drosophila

Mahmut Selman Sakar, Pavan P Ramdya, Murat Kaynak, Semih Günel, Chin-Lin Chen, Florian Aymanns, Victor Lobato Rios, Jonas Friedrich Braun, Laura Joan Hermans

The dynamics and connectivity of neural circuits continuously change on timescales ranging from milliseconds to an animal's lifetime. Therefore, to understand biological networks, minimally invasive methods are required to repeatedly record them in behavin ...

Nature Research2022

Modeling the mechanosensitive collective migration of cells on the surface and the interior of morphing soft tissues

Mahmut Selman Sakar, Jaemin Kim

Cellular contractility, migration, and extracellular matrix (ECM) mechanics are critical for a wide range of biological processes including embryonic development, wound healing, tissue morphogenesis, and regeneration. Even though the distinct response of c ...

Springer Science and Business Media LLC2024

Engineered Extracellular Matrices with Integrated Wireless Microactuators to Study Mechanobiology

Mahmut Selman Sakar, Erik Mailand, Nikolaos Bouklas, Fazil Emre Uslu

Mechanobiology explores how forces regulate cell behaviors and what molecular machinery are responsible for the sensing, transduction, and modulation of mechanical cues. To this end, probing of cells cultured on planar substrates has served as a primary ex ...

Wiley2021

Addressable Acoustic Actuation of 3D Printed Soft Robotic Microsystems

Mahmut Selman Sakar, Murat Kaynak, Pietro Luciano Jakobus Dirix

A design, manufacturing, and control methodology is presented for the transduction of ultrasound into frequency-selective actuation of multibody hydrogel mechanical systems. The modular design of compliant mechanisms is compatible with direct laser writing ...

2020

Tissue Engineering with Mechanically Induced Solid‐Fluid Transitions

Mahmut Selman Sakar, Jaemin Kim, Ece Özelçi, Erik Mailand, Nikolaos Bouklas, Matthias Rüegg

Epithelia are contiguous sheets of cells that stabilize the shape of internal organs and support their structure by covering their surfaces. They acquire diverse morphological forms appropriate for their specific functions during embryonic development, suc ...

Wiley2021

Colloidal self-assembly of soft neural interfaces from injectable photovoltaic microdevices

Mahmut Selman Sakar, Zhangjun Huang, Murat Kaynak, Haiyan Jia

Biomimetic retinas with a wide field of view and high resolution are in demand for neuroprosthetics and robot vision. Conventional neural prostheses are manufactured outside the application area and implanted as a complete device using invasive surgery. He ...

2023

Active biomaterials for mechanobiology

Mahmut Selman Sakar, Berna Ayse Özkale Edelmann

Active biomaterials offer novel approaches to study mechanotransduction in mammalian cells. These material systems probe cellular responses by dynamically modulating their resistance to endogenous forces or applying exogenous forces on cells in a temporall ...

2020

3D Printed Acoustically Programmable Soft Microactuators

Mahmut Selman Sakar, Murat Kaynak, Amit Yedidia Dolev

The concept of creating all-mechanical soft microrobotic systems has great potential to address outstanding challenges in biomedical applications, and introduce more sustainable and multifunctional products. To this end, magnetic fields and light have been ...

2023

Modular soft robotic microdevices for dexterous biomanipulation

Francesco Stellacci, Mahmut Selman Sakar, Ahmet Bekdemir, Murat Kaynak, Ece Özelçi, Berna Ayse Özkale Edelmann, Lucio Feo Pancaldi-Giubbini, Raquel Filipa Penacho Parreira

We present a methodology for building biologically inspired, soft microelectromechanical systems (MEMS) devices. Our strategy combines several advanced techniques including programmable colloidal self-assembly, light-harvesting with plasmonic nanotransduce ...

2019

Soft micromachines with programmable motility and morphology

Mahmut Selman Sakar

Nature provides a wide range of inspiration for building mobile micromachines that can navigate through confined heterogenous environments and perform minimally invasive environmental and biomedical operations. For example, microstructures fabricated in th ...

Nature Research2016

Targeted worker removal reveals a lack of flexibility in brood transport specialisation with no compensatory gain in efficiency

Mahmut Selman Sakar, Laurent Keller, Fazil Emre Uslu

Division of labour is widely thought to increase the task efficiency of eusocial insects. Workers can switch their task to compensate for sudden changes in demand, providing flexible task allocation. In combination with automated tracking technology, we de ...

Nature Research2024

Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy

Georg Fantner, Li Tang, Mahmut Selman Sakar, Yugang Guo, Murat Kaynak, Mélanie Thérèse Marie Hannebelle, Armand Kurum, Kewen Lei, Lucia Bonati, Yuqing Xie, Min Gao, Veronika Cencen

Cancer cells enriched in cholesterol in their plasma membrane impair T-cell-mediated cytotoxicity, which can be augmented by stiffening the cancer cells via cholesterol depletion, as shown in mouse models of adoptive T-cell immunotherapy. Malignant transfo ...

2021

Small-scale robotic devices for medical interventions in the brain

Mahmut Selman Sakar, Lorenzo Francesco John Noseda

This article summarizes the recent advancements in the design, fabrication, and control of microrobotic devices for the diagnosis and treatment of brain disorders. With a focus on diverse actuation methods, we discuss how advancements in materials science ...

2024

Flow driven robotic navigation of microengineered endovascular probes

Nikolaos Stergiopoulos, Diego Ghezzi, Mahmut Selman Sakar, Augusto Martins Lima, Lucio Feo Pancaldi-Giubbini, Adele Fanelli, Pietro Luciano Jakobus Dirix

Minimally invasive medical procedures, such as endovascular catheterization, have considerably reduced procedure time and associated complications. However, many regions inside the body, such as in the brain vasculature, still remain inaccessible due to th ...

Nature Research2020

A Flat Tendon-Driven Continuum Microrobot for Brain Interventions

Mahmut Selman Sakar, Lucio Feo Pancaldi-Giubbini, Lorenzo Francesco John Noseda

Navigating biomedical instruments inside the brain remains challenging and high-risk. The delicate nature of the tissues involved requires the development of cutting-edge robotic technologies to enhance precision and safety. In response to these demands, t ...

Institute of Electrical and Electronics Engineers Inc.2024

Actuated 3D microgels for single cell mechanobiology

Mahmut Selman Sakar, Ece Özelçi, Berna Ayse Özkale Edelmann, Christina Myra Tringides

We present a new cell culture technology for large-scale mechanobiology studies capable of generating and applying optically controlled uniform compression on single cells in 3D. Mesenchymal stem cells (MSCs) are individually encapsulated inside an optical ...

ROYAL SOC CHEMISTRY2022

3D printed large amplitude torsional microactuators powered by ultrasound

Mahmut Selman Sakar, Amit Yedidia Dolev, Mehdi Ali Gadiri, Junsun Hwang

Here, we introduce a design, fabrication, and control methodology for large amplitude torsional microactuators powered by ultrasound. The microactuators are 3D printed from two polymers with drastically different elastic moduli as a monolithic compliant me ...

2024