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Mahmut Selman Sakar

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Related publications (47)

Investigating Tissue Mechanics in vitro Using Untethered Soft Robotic Microdevices

Mahmut Selman Sakar, Raquel Filipa Penacho Parreira, Ece Özelçi

This paper presents the design, fabrication, and operation of a soft robotic compression device that is remotely powered by laser illumination. We combined the rapid and wireless response of hybrid nanomaterials with state-of-the-art microengineering techn ...

2021

Ultraflexible flow directed device and system

Lucio Feo Pancaldi-Giubbini, Pietro Luciano Jakobus Dirix, Mahmut Selman Sakar

A flow directed device adapted to be guided by a fuid, such as blood, flow within a tubular structure such as a blood vessel is disclosed, said device comprising a proximal end (100), a distal end (101) and an elongated body (102) in between defining a lon ...

2021

Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy

Armand Kurum, Georg Fantner, Mélanie Thérèse Marie Hannebelle, Mahmut Selman Sakar, Yuqing Xie, Li Tang, Murat Kaynak, Kewen Lei, Yugang Guo, Min Gao, Veronika Cencen, Lucia Bonati

Cancer cells enriched in cholesterol in their plasma membrane impair T-cell-mediated cytotoxicity, which can be augmented by stiffening the cancer cells via cholesterol depletion, as shown in mouse models of adoptive T-cell immunotherapy. Malignant transfo ...

2021

On-Board Mechanical Control Systems for Untethered Microrobots

Mahmut Selman Sakar, Murat Kaynak, Amit Yedidia Dolev

2021

Pulsatile Flow-Induced Fatigue-Resistant Photopolymerizable Hydrogels for the Treatment of Intracranial Aneurysms

Dominique Pioletti, Andreas Schmocker, Lucio Feo Pancaldi-Giubbini, Christophe Moser, Mahmut Selman Sakar, Oriane Poupart

An alternative intracranial aneurysm embolic agent is emerging in the form of hydrogels due to their ability to be injected in liquid phase and solidify in situ. Hydrogels have the ability to fill an aneurysm sac more completely compared to solid implants ...

2021

Engineered Extracellular Matrices with Integrated Wireless Microactuators to Study Mechanobiology

Mahmut Selman Sakar, Erik Mailand, Nikolaos Bouklas, Fazil Emre Uslu

Mechanobiology explores how forces regulate cell behaviors and what molecular machinery are responsible for the sensing, transduction, and modulation of mechanical cues. To this end, probing of cells cultured on planar substrates has served as a primary ex ...

Wiley2021

Tissue Engineering with Mechanically Induced Solid‐Fluid Transitions

Jon Märki, Matthias Rüegg, Mahmut Selman Sakar, Erik Mailand, Ece Özelçi, Nikolaos Bouklas, Odysseas Konstantinos Chaliotis, Jaemin Kim

Epithelia are contiguous sheets of cells that stabilize the shape of internal organs and support their structure by covering their surfaces. They acquire diverse morphological forms appropriate for their specific functions during embryonic development, suc ...

Wiley2021

Addressable Acoustic Actuation of 3D Printed Soft Robotic Microsystems

Pietro Luciano Jakobus Dirix, Mahmut Selman Sakar, Murat Kaynak

A design, manufacturing, and control methodology is presented for the transduction of ultrasound into frequency-selective actuation of multibody hydrogel mechanical systems. The modular design of compliant mechanisms is compatible with direct laser writing ...

2020

Flow driven robotic navigation of microengineered endovascular probes

Nikolaos Stergiopoulos, Lucio Feo Pancaldi-Giubbini, Pietro Luciano Jakobus Dirix, Diego Ghezzi, Mahmut Selman Sakar, Augusto Martins Lima, Adele Fanelli

Minimally invasive medical procedures, such as endovascular catheterization, have considerably reduced procedure time and associated complications. However, many regions inside the body, such as in the brain vasculature, still remain inaccessible due to th ...

Nature Research2020

Remotely Controlled Colloidal Assembly of Soft Microrobotic Artificial Muscle

Mahmut Selman Sakar, Raquel Filipa Penacho Parreira, Ece Özelçi

2020

Kinematic and dynamic analysis of the mosquito larvae gait

Auke Ijspeert, Laura Isabel Paez Coy, Kamilo Andres Melo Becerra, Mahmut Selman Sakar

OXFORD UNIV PRESS INC2020

Active biomaterials for mechanobiology

Mahmut Selman Sakar, Berna Ayse Özkale Edelmann

Active biomaterials offer novel approaches to study mechanotransduction in mammalian cells. These material systems probe cellular responses by dynamically modulating their resistance to endogenous forces or applying exogenous forces on cells in a temporall ...

2020

A model for 3D deformation and reconstruction of contractile microtissues

Mahmut Selman Sakar, Erik Mailand, Nikolaos Bouklas, Jaemin Kim

Tissue morphogenesis and regeneration are essentially mechanical processes that involve coordination of cellular forces, production and structural remodeling of extracellular matrix (ECM), and cell migration. Discovering the principles of cell–ECM interact ...

2020

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

Beat Fierz, Andrea Ablasser, Mahmut Selman Sakar, Murat Kaynak, Baptiste Claude André Guey, Alexiane Clara Decout, Marilena Wischnewski, Kristina Makasheva

The appearance of DNA in the cytosol is perceived as a danger signal that stimulates potent immune responses through cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS). How cells regulate the activity of cGAS toward self-DNA and guard a ...

American Association for the Advancement of Science2020

Surface and bulk stresses drive morphological changes in fibrous microtissues

Mahmut Selman Sakar, Erik Mailand, Nikolaos Bouklas

Engineered fibrous tissues consisting of cells encapsulated within collagen gels are widely used three-dimensional (3D) in vitro models of morphogenesis and wound healing. While cell-mediated matrix remodeling that occurs within these scaffolds has been ex ...

2019

Adaptive locomotion of artificial microswimmers

Mahmut Selman Sakar, Fazil Emre Uslu

Bacteria can exploit mechanics to display remarkable plasticity in response to locally changing physical and chemical conditions. Compliant structures play a notable role in their taxis behavior, specifically for navigation inside complex and structured en ...

2019

Modular soft robotic microdevices for dexterous biomanipulation

Lucio Feo Pancaldi-Giubbini, Francesco Stellacci, Ahmet Bekdemir, Mahmut Selman Sakar, Raquel Filipa Penacho Parreira, Ece Özelçi, Berna Ayse Özkale Edelmann, Murat Kaynak

We present a methodology for building biologically inspired, soft microelectromechanical systems (MEMS) devices. Our strategy combines several advanced techniques including programmable colloidal self-assembly, light-harvesting with plasmonic nanotransduce ...

2019

Compound micromachines powered by acoustic streaming

Mahmut Selman Sakar, Murat Kaynak, Furkan Ayhan

This paper presents the design, fabrication, and operation of compound micromachines powered by acoustic streaming. The machine components were directly incorporated around pillars serving as shafts without further assembly steps using a single-step in sit ...

IEEE2019

Universal Soft Robotic Microgripper

Giovanni Dietler, Mahmut Selman Sakar, Erik Mailand, Jiangtao Zhou, Zhangjun Huang, John Martin Kolinski, Haiyan Jia, Xunhui Wang

2019

Engineering Control over 3D Morphogenesis by Tissue Origami

Mahmut Selman Sakar

Cell Press - Elsevier2018

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