Publications by Diego Ghezzi | EPFL Graph Search

Related publications (48)

Gene Editing Preserves Visual Functions in a Mouse Model of Retinal Degeneration

Diego Ghezzi, Naïg Aurelia Ludmilla Chenais, Paola Vagni

Inherited retinal dystrophies (IRDs) are a large and heterogeneous group of degenerative diseases caused by mutations in various genes. Given the favorable anatomical and immunological characteristics of the eye, gene therapy holds great potential for thei ...

2019

Changes Over Time in the Electrode/Brain Interface Impedance: An Ex-Vivo Study

Sandro Carrara, Diego Ghezzi, Gian Luca Barbruni

Closed-loop neural implants based on continuous brain activity recording and intracortical microstimulation are extremely effective and promising devices to monitor and address many neurodegenerative diseases. The efficiency of these devices depends on the ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2023

A machine-learning algorithm correctly classifies cortical evoked potentials from both visual stimulation and electrical stimulation of the optic nerve

Diego Ghezzi, Eleonora Borda, Vivien Gaillet, Elodie Geneviève Zollinger

Objective. Optic nerve's intraneural stimulation is an emerging neuroprosthetic approach to provide artificial vision to totally blind patients. An open question is the possibility to evoke individual non-overlapping phosphenes via selective intraneural op ...

IOP PUBLISHING LTD2021

Three-dimensional multilayer concentric bipolar electrodes restrict spatial activation in optic nerve stimulation

Diego Ghezzi, Marta Jole Ildelfonsa Airaghi Leccardi, Eleonora Borda, Vivien Gaillet, Elodie Geneviève Zollinger

Objective. Intraneural nerve interfaces often operate in a monopolar configuration with a common and distant ground electrode. This configuration leads to a wide spreading of the electric field. Therefore, this approach is suboptimal for intraneural nerve ...

IOP Publishing Ltd2022

In vivo recording of visually evoked potentials with novel full diamond ECoG implants

Diego Ghezzi, Eleonora Borda

Implantable neuroprosthetic devices such as electrocorticography (ECoG) and intracortical microelectrodes have the potential to restore neurological functions in disabled individuals. They constitute the direct interface with the body and require long term ...

2024

Naturalistic spatiotemporal modulation of epiretinal stimulation increases the response persistence of retinal ganglion cell

Diego Ghezzi, Marta Jole Ildelfonsa Airaghi Leccardi, Naïg Aurelia Ludmilla Chenais

Objective. Retinal stimulation in blind patients evokes the sensation of discrete points of light called phosphenes, which allows them to perform visually guided tasks, such as orientation, navigation, object recognition, object manipulation and reading. H ...

2021

Wide-angle simulated artificial vision enhances spatial navigation and object interaction in a naturalistic environment

Diego Ghezzi, Sandrine Brikh

Objective. Vision restoration approaches, such as prosthetics and optogenetics, provide visual perception to blind individuals in clinical settings. Yet their effectiveness in daily life remains a challenge. Stereotyped quantitative tests used in clinical ...

2024

Upper stimulation threshold for retinal ganglion cell activation

Diego Ghezzi

Objective. The existence of an upper threshold in electrically stimulated retinal ganglion cells (RGCs) is of interest because of its relevance to the development of visual prosthetic devices, which are designed to restore partial sight to blind patients. ...

2018

Multilayer 3D electrodes for neural implants

Diego Ghezzi, Marta Jole Ildelfonsa Airaghi Leccardi, Paola Vagni

Objective. In many applications, multielectrode arrays employed as neural implants require a high density and a high number of electrodes to precisely record and stimulate the activity of the nervous system while preserving the overall size of the array as ...

2018

Locomotion of Sensor‐Integrated Soft Robotic Devices Inside Sub‐Millimeter Arteries with Impaired Flow Conditions

Diego Ghezzi, Mahmut Selman Sakar, Amit Yedidia Dolev, Lucio Feo Pancaldi-Giubbini, Adele Fanelli, Lorenzo Francesco John Noseda

One of the grand challenges in interventional cardiology and neuroradiology is to minimize the operation time and risk of damage during catheterization. These two factors drastically increase if the target location resides in small and tortuous vessels. Fl ...

Wiley2022

Bodily implant microelectrode and bodily implant microelectrode fabrication method

Sandro Carrara, Diego Ghezzi, Gian Luca Barbruni

The present invention concerns a bodily implantable or probe device and microelectrode fabrication method comprising providing at least one silicon substrate including an electronic device or unit; providing, on a first side of the silicon substrate, at le ...

2024

Capacitive-like photovoltaic epiretinal stimulation enhances and narrows the network-mediated activity of retinal ganglion cells by recruiting the lateral inhibitory network

Diego Ghezzi, Marta Jole Ildelfonsa Airaghi Leccardi, Naïg Aurelia Ludmilla Chenais

Photovoltaic retinal prostheses theoretically offer the possibility of a standalone high-resolution electrical stimulation of the retina. However, achieving focused epiretinal stimulation is particularly challenging, because of axonal activation and electr ...

2019

Polymer-based optoelectronic interface and methods for its manufacture

Diego Ghezzi, Marta Jole Ildelfonsa Airaghi Leccardi, Laura Ferlauto

A polymer-based optoelectronic interface comprises an elastomeric substrate (10) and a plurality of discrete photovoltaic pixel elements (20) disposed on top of the substrate. Each pixel element comprises at least one active layer comprising a semiconducti ...

2018

Photovoltaic organic interface for neuronal stimulation in the near-infrared

Diego Ghezzi, Marta Jole Ildelfonsa Airaghi Leccardi, Laura Ferlauto, Naïg Aurelia Ludmilla Chenais, Elodie Geneviève Zollinger

Organic materials, such as conjugated polymers, are attractive building blocks for bioelectronic interfaces. In particular, organic semiconductors show excellent performance in light-mediated excitation and silencing of neuronal cells and tissues. However, ...

2020

Advances in visual prostheses: engineering and biological challenges

Diego Ghezzi, Eleonora Borda

Vision is an extraordinary sense through which we can appreciate the beauty of the world we live in, gain invaluable knowledge and communicate with others using visual expression and arts. On the contrary, blindness is a threatening medical condition disru ...

IOP Publishing Ltd2022

A microfabricated nerve-on-a-chip platform for rapid assessment of neural conduction in explanted peripheral nerve fibers

Stéphanie Lacour, Diego Ghezzi, Sandra Gribi

Peripheral nerves are anisotropic and heterogeneous neural tissues. Their complex physiology restricts realistic in vitro models, and high resolution and selective probing of axonal activity. Here, we present a nerve-on-a-chip platform that enables rapid e ...

Nature Research2018

The role of the visual field size in artificial vision

Diego Ghezzi

Objective. Artificial vision has been and still is the subject of intense research. The ultimate goal is to help blind people in their daily life. Approaches to artificial vision, including visual prostheses and optogenetics, have strongly focused on resto ...

IOP Publishing Ltd2023

Flow driven robotic navigation of microengineered endovascular probes

Nikolaos Stergiopoulos, Diego Ghezzi, Mahmut Selman Sakar, Augusto Martins Lima, Lucio Feo Pancaldi-Giubbini, Adele Fanelli, Pietro Luciano Jakobus Dirix

Minimally invasive medical procedures, such as endovascular catheterization, have considerably reduced procedure time and associated complications. However, many regions inside the body, such as in the brain vasculature, still remain inaccessible due to th ...

Nature Research2020

Transient Neurovascular Interface for Minimally Invasive Neural Recording and Stimulation

Diego Ghezzi, Philippe Reymond, Laura Ferlauto, Adele Fanelli, Elodie Geneviève Zollinger

Neural interfaces are used to mitigate the burden of traumatic injuries, neurodegenerative diseases, and mental disorders. However, the transient or permanent placement of an interface in close contact with the neural tissue requires invasive surgery, pote ...

Wiley2021

Photovoltaic retinal prosthesis restores high-resolution responses to single-pixel stimulation in blind retinas

Diego Ghezzi, Marta Jole Ildelfonsa Airaghi Leccardi, Naïg Aurelia Ludmilla Chenais

Retinal prostheses hold the promise of restoring vision in totally blind people. However, a decade of clinical trials highlighted quantitative limitations hampering the possibility of reaching this goal. A key challenge in retinal stimulation is to indepen ...

2021