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Andrea Ablasser

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Related publications (44)

Regulation of cGAS- and RLR-mediated immunity to nucleic acids

Pathogen-derived nucleic acids are crucial signals for innate immunity. Despite the structural similarity between those and host nucleic acids, mammalian cells have been able to evolve powerful innate immune signaling pathways that originate from the detec ...

NATURE PUBLISHING GROUP2020

Structural mechanism of cGAS inhibition by the nucleosome

Rudolf Hovius, Simone Cavadini, Beat Fierz, Andrea Ablasser, Sélène-Véronique Glück, Baptiste Claude André Guey, Alexiane Clara Decout, Kristina Makasheva, Pauline Ambre Melenec

The DNA sensor cGAS initiates innate immune responses following microbial infection, cellular stress, and cancer1. Upon activation by double-stranded DNA, cytosolic cGAS produces 2’3’ cyclic GMP-AMP and triggers inflammatory cytokine and type I interferon ...

2020

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

Beat Fierz, Andrea Ablasser, Mahmut Selman Sakar, Murat Kaynak, Baptiste Claude André Guey, Alexiane Clara Decout, Marilena Wischnewski, Kristina Makasheva

The appearance of DNA in the cytosol is perceived as a danger signal that stimulates potent immune responses through cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS). How cells regulate the activity of cGAS toward self-DNA and guard a ...

American Association for the Advancement of Science2020

COPA silences STING

Sophie Marie Elisabeth Rivara, Andrea Ablasser

Two studies published in this issue of JEM, by Lepelley et al. (https://doi.org/10.1084/jem.20200600) and Deng et al. (https:// doi.org/10.1084/jem.20201045), and two additional manuscripts by Mukai et al. (https://doi.org/10.1101/2020.05.20. 107664 Prepri ...

ROCKEFELLER UNIV PRESS2020

Sting inhibitors

Luc Reymond, Andrea Ablasser, Simone Margret Haag

The present invention relates to compounds, compositions for use and methods for the treatment of a STING associated disease, condition, or disorder. ...

2019

Latest advances in aging research and drug discovery

Andrea Ablasser

An increasing aging population poses a significant challenge to societies worldwide. A better understanding of the molecular, cellular, organ, tissue, physiological, psychological, and even sociological changes that occur with aging is needed in order to t ...

IMPACT JOURNALS LLC2019

cGAS in action: Expanding roles in immunity and inflammation

Andrea Ablasser, Jane Jingyi Chen

American Association for the Advancement of Science2019

A carrier for cyclic dinucleotides

Andrea Ablasser, Baptiste Claude André Guey

Cyclic dinucleotides (CDNs) are potent activators of the innate immune sensor STING. The identification of a CDN importer sheds new light on the regulation of extracellular CDNs. ...

NATURE PUBLISHING GROUP2019

Virology: Poxins Soothe the STING

Andrea Ablasser, Alexiane Clara Decout

The mammalian cyclic dinucleotide 2', 3'-cGAMP is a potent inducer of innate immune responses produced upon detection of cytosolic DNA by cGAS. The mechanisms underlying the control of intracellular cGAMP levels remained unclear. In a new study, Eaglesham ...

CELL PRESS2019

Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling

Alix Martin, Thomas Charles Henry Rossi, Ensieh Farahani, Andrea Ablasser, Bing Zhang

The innate immune system is crucial for eventual control of infections, but may also contribute to pathology. Listeria monocytogenes is an intracellular Gram-positive bacteria and a major cause of food-borne disease. However, important knowledge on the int ...

NATURE PUBLISHING GROUP2019

Sting inhibitors

Luc Reymond, Andrea Ablasser, Simone Margret Haag

The present invention relates to compounds, compositions for use and methods for the treatment of a STING associated disease, condition, or disorder. ...

2019

Sting inhibitors

Luc Reymond, Andrea Ablasser, Simone Margret Haag

The present invention relates to compounds, compositions for use and methods for the treatment of a STING associated disease, condition, or disorder. ...

2019

Inflammation clues in STING protein structure

Andrea Ablasser

The STING protein aids intracellular defences by triggering inflammation. Studies that uncover how STING is activated might lead to strategies for targeting this protein in the treatment of cancer or autoimmune diseases. ...

NATURE PUBLISHING GROUP2019

Human cGAS Has a Slightly Different Taste for dsDNA

Andrea Ablasser, Alexiane Clara Decout

2018

Innate immunosensing of DNA in cellular senescence

Andrea Ablasser, Sélène-Véronique Glück

2018

Phase separation focuses DNA sensing

Andrea Ablasser

American Association for the Advancement of Science2018

Targeting STING with covalent small-molecule inhibitors

Gerardo Turcatti, Luc Reymond, Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Andrea Ablasser, Muhammet Fatih Gülen, Simone Margret Haag, Michael Christian Heymann, Alexiane Clara Decout

2018

Signalling strength determines proapoptotic functions of STING

Freddy Radtke, Ute Koch, Andrea Ablasser, Muhammet Fatih Gülen

Mammalian cells use cytosolic nucleic acid receptors to detect pathogens and other stress signals. In innate immune cells the presence of cytosolic DNA is sensed by the cGAS-STING signalling pathway, which initiates a gene expression programme linked to ce ...

Springer Nature2017

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

Andrea Ablasser, Muhammet Fatih Gülen, Sélène-Véronique Glück, Niklas Arndt Schmacke, Baptiste Claude André Guey

2017

ReGLUation of cGAS

Andrea Ablasser

The detection of cytosolic DNA by the sensor cGAS triggers potent antiviral responses. New data now propose that cGAS is regulated on a post-translational level by glutamylation. ...

Nature Publishing Group2016

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