Publication

The cGAS-STING pathway as a therapeutic target in inflammatory diseases

Andrea Ablasser, Alexiane Clara Decout
2021
Reviews

Abstract

The cGAS-STING pathway drives innate immune activation in response to cytosolic DNA. This is important for immunity to bacteria and viruses, but aberrant cGAS-STING activity is also linked to inflammatory disease. Here, Ablasser and colleagues discuss how cGAS-STING signalling contributes to various autoimmune, inflammatory and degenerative diseases and describe the novel therapeutics targeting this pathway.

Official source

https://infoscience.epfl.ch/entities/publication/d70453ba-f762-4dd1-ba17-274ded96af6a

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