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Andrea Ablasser

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Publications associées (40)

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Virology: Poxins Soothe the STING

Andrea Ablasser, Alexiane Clara Decout

The mammalian cyclic dinucleotide 2', 3'-cGAMP is a potent inducer of innate immune responses produced upon detection of cytosolic DNA by cGAS. The mechanisms underlying the control of intracellular cGAMP levels remained unclear. In a new study, Eaglesham ...

CELL PRESS2019

Sting inhibitors

Andrea Ablasser, Luc Reymond, Simone Margret Haag

The present invention relates to compounds, compositions for use and methods for the treatment of a STING associated disease, condition, or disorder. ...

2019

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

Beat Fierz, Mahmut Selman Sakar, Andrea Ablasser, Murat Kaynak, Kristina Makasheva, Alexiane Clara Decout, Baptiste Claude André Guey, Marilena Wischnewski

The appearance of DNA in the cytosol is perceived as a danger signal that stimulates potent immune responses through cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS). How cells regulate the activity of cGAS toward self-DNA and guard a ...

American Association for the Advancement of Science2020

Inside Job: Viruses Transfer cGAMP between Cells

Andrea Ablasser, Muhammet Fatih Gülen

The DNA sensor, cyclic GMP-AMP synthase (cGAS), is essential for the detection of viral infection. In a recent issue of Science, two studies, Bridgeman et al. (2015) and Gentili et al. (2015), report a novel mechanism for propagating an antiviral signal be ...

Cell Press2015

The role of cGAS in innate immunity and beyond

Andrea Ablasser, Muhammet Fatih Gülen

The sensing of foreign DNA is crucial for host defense against several pathogens. In the cytosol the enzyme cyclic GMP-AMP synthase (cGAS) is critical for the recognition of pathogen-derived DNA and provides key signals that initiate immune responses. Beyo ...

2016

Cgas super-enzymes for cancer immunotherapy

Andrea Ablasser, Natasha Ella Samson, Alexander Scott Keller

The present invention relates to anti-tumor lymphocytes, and a variant cyclic GMP-AMP synthase (cGAS) carrying an amino acid substitution of one or both arginines at amino acid positions 255 and 236 and/or an amino acid substitution of one or both lysines ...

2023

Regulation of the cGAS-STING Pathway

Bing Zhang, Andrea Ablasser, Pengbiao Xu

The cGAS-cGAMP-STING pathway is essential for immune defense against pathogens. Upon binding DNA, cGAS synthesizes cGAMP, which activates STING, leading to potent innate immune effector responses. However, lacking specific features to distinguish between s ...

Annual Reviews2025

Editorial overview 'Network news: Reporting from the frontlines of cell signaling'

Andrea Ablasser

CURRENT BIOLOGY LTD2020

STING inhibition in myocardial remodelling following myocardial infarction

Andrea Ablasser

OXFORD UNIV PRESS2021

Sting inhibitors

Andrea Ablasser, Luc Reymond, Simone Margret Haag

The present invention relates to compounds, compositions for use and methods for the treatment of a STING associated disease, condition, or disorder. ...

2019

Phase separation focuses DNA sensing

Andrea Ablasser

American Association for the Advancement of Science2018

The crl5spsb3 ubiquitin ligase targets nuclear cgas for degradation

Andrea Ablasser, Pengbiao Xu, Lingyun Li

The present invention relates to a variant of cyclic GMP-AMP synthase (cGAS) carrying an amino acid substitution at one or more of (i) asparagine at amino acid position 513, (ii) asparagine at amino acid position 514, (iii) aspartic acid at amino acid posi ...

2024

Sting inhibitors

Andrea Ablasser, Luc Reymond, Simone Margret Haag

The present invention relates to compounds, compositions for use and methods for the treatment of a STING associated disease, condition, or disorder. ...

2019

DNA sensor in standby mode during mitosis

Andrea Ablasser

American Association for the Advancement of Science2021

The cGAS-STING pathway as a therapeutic target in inflammatory diseases

Andrea Ablasser, Alexiane Clara Decout

The cGAS-STING pathway drives innate immune activation in response to cytosolic DNA. This is important for immunity to bacteria and viruses, but aberrant cGAS-STING activity is also linked to inflammatory disease. Here, Ablasser and colleagues discuss how ...

NATURE RESEARCH2021

STING-Inhibition after myocardial infarction

Andrea Ablasser

SPRINGER WIEN2021

ReGLUation of cGAS

Andrea Ablasser

The detection of cytosolic DNA by the sensor cGAS triggers potent antiviral responses. New data now propose that cGAS is regulated on a post-translational level by glutamylation. ...

Nature Publishing Group2016

A carrier for cyclic dinucleotides

Andrea Ablasser, Baptiste Claude André Guey

Cyclic dinucleotides (CDNs) are potent activators of the innate immune sensor STING. The identification of a CDN importer sheds new light on the regulation of extracellular CDNs. ...

NATURE PUBLISHING GROUP2019

Targeting STING with covalent small-molecule inhibitors

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Gerardo Turcatti, Andrea Ablasser, Luc Reymond, Muhammet Fatih Gülen, Alexiane Clara Decout, Simone Margret Haag

2018

COPA silences STING

Andrea Ablasser, Sophie Marie Elisabeth Rivara

Two studies published in this issue of JEM, by Lepelley et al. (https://doi.org/10.1084/jem.20200600) and Deng et al. (https:// doi.org/10.1084/jem.20201045), and two additional manuscripts by Mukai et al. (https://doi.org/10.1101/2020.05.20. 107664 Prepri ...

ROCKEFELLER UNIV PRESS2020