Publication

Cgas super-enzymes for cancer immunotherapy

Andrea Ablasser, Natasha Ella Samson, Alexander Scott Keller
2023
Patents

Abstract

The present invention relates to anti-tumor lymphocytes, and a variant cyclic GMP-AMP synthase (cGAS) carrying an amino acid substitution of one or both arginines at amino acid positions 255 and 236 and/or an amino acid substitution of one or both lysines at amino acid positions 254 and 258; or a nucleic acid molecule encoding said variant cGAS for use in the treatment of a tumor in a subject.

Official source

https://infoscience.epfl.ch/entities/publication/de99171f-19dd-412b-8904-5935595eabcd

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Cgas super-enzymes for cancer immunotherapy

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