Home

Person

Hatice Altug

About
Privacy
Disclaimer

Graph Chatbot

Related publications (119)

Page 2 of 6

Artificial intelligence-coupled plasmonic infrared sensor for detection of structural protein biomarkers in neurodegenerative diseases

Hilal Lashuel, Hatice Altug, Rajasekhar Kolla, Deepthy Kavungal, Pedro José Santana Ribeiro Magalhães, Senthil Kumar Thangaraj

Diagnosis of neurodegenerative disorders (NDDs) including Parkinson's disease and Alzheimer's disease is challenging owing to the lack of tools to detect preclinical biomarkers. The misfolding of proteins into oligomeric and fibrillar aggregates plays an i ...

AMER ASSOC ADVANCEMENT SCIENCE2023

Ultrasensitive hyperspectral imaging and biodetection enabled by dielectric metasurfaces

Volkan Cevher, Hatice Altug, Filiz Yesilköy, Andreas Tittl, Yasaman Jahani, Eduardo Romero Arvelo

Metasurfaces based on resonant subwavelength photonic structures enable novel ways of wavefront control and light focusing, underpinning a new generation of flat-optics devices. Recently emerged all-dielectric asymmetric metasurfaces, composed of arrays of ...

Nature Publishing Group2019

Label-free, scalable and point-of-care imaging platform for rapid analysis of biomarker

Hatice Altug, Filiz Yesilköy, Alexander Belushkin, Yasaman Jahani

We propose a disruptive point-of-care (PoC) imaging platform based on lens-free interference phase-contrast imaging for rapid detection of biomarker such as for sepsis and potentially other diseases (e.g. cancer). It enables simultaneous analysis of potent ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Mid-infrared plasmonic biosensing with graphene

Hatice Altug, Dordaneh Etezadi, Daniel Rodrigo Lopez

Infrared spectroscopy is the technique of choice for chemical identification of biomolecules through their vibrational fingerprints. However, infrared light interacts poorly with nanometric-size molecules. We exploit the unique electro-optical properties o ...

American Association for the Advancement of Science2015

Self-Similar Multiresonant Nanoantenna Arrays for Sensing from Near- to Mid-Infrared

Hatice Altug, Andreas Tittl, Aurélian Michel John-Herpin, Daniel Rodrigo Lopez

Tailoring nanoscale light concentration and electromagnetic near-field enhancement over a broad spectral range is crucial for many photonics applications such as infrared spectroscopy, photodetection, and light harvesting. So far, broadband light enhanceme ...

2018

Method and spectrometer apparatus for investigating an infrared absorption of a sample

Hatice Altug, Andreas Tittl, Aleksandrs Leitis

A method of investigating a sample (1) having an absorption within an infrared spectral range of interest, comprises the steps of creating measuring light (2) with a light source device (10), wherein the measuring light (2) includes wavelengths covering th ...

2019

Plasmonic and Dielectric Metasurfaces for Molecular Specific Mid-IR Biosensors

Hatice Altug

Mid-infrared spectrum is powerful for biosensing application, as it encompasses the molecular vibrations that uniquely identify the biochemicals. Here, we will present our contributions using metal, graphene and dielectric based Mid-IR nanophotonics. ...

IEEE2018

Wafer‐Scale Functional Metasurfaces for Mid‐Infrared Photonics and Biosensing

Hatice Altug, Aleksandrs Leitis, Aurélian Michel John-Herpin, Ming-Lun Tseng

Metasurfaces have emerged as a breakthrough platform for manipulating light at the nanoscale and enabling on-demand optical functionalities for next-generation biosensing, imaging, and light-generating photonic devices. However, translating this technology ...

Wiley2021

Actively transporting virus like analytes with optofluidics for rapid and ultrasensitive biodetection

Hatice Altug, Min Huang

Effective analyte delivery is essential to achieve rapid and sensitive biodetection systems. In this article, we present an actively controlled fluidic system integrated with a suspended plasmonic nanohole sensor to achieve superior analyte delivery effici ...

2013

Towards a point-of-care nanoplasmonic biosensor for rapid and multiplexed detection of pathogenic infections

Hatice Altug, Filiz Yesilköy, Alexander Belushkin, Xiaokang Li, Maria Soler Aznar

The implementation of multiplexed point-of-care biosensors is a top priority to address the current epidemic problems originated by widespread pathogenic infections, like those caused by viruses or bacteria. A rapid and accurate detection, identification, ...

SPIE-INT SOC OPTICAL ENGINEERING2018

Mining the Potential of Label-Free Biosensors for In Vitro Antipsychotic Drug Screening

Sandro Carrara, Hatice Altug, Tugba Kilic, Maria Soler Aznar

The pharmaceutical industry is facing enormous challenges due to high drug attribution rates. For the past decades, novel methods have been developed for safety and efficacy testing, as well as for improving early development stages. In vitro screening met ...

2018

Label-free Bacteria Quantification in Blood Plasma by a Bioprinted Microarray Based Interferometric Point-of-Care Device

Hatice Altug, Filiz Yesilköy, Alexander Belushkin

Existing clinical methods for bacteria detection lack speed, sensitivity, and, importantly, point-of-care (PoC) applicability. Thus, finding ways to push the sensitivity of clinical PoC biosensing technologies is crucial. Here we report a portable PoC devi ...

AMER CHEMICAL SOC2019

Advances and applications of nanophotonic biosensors

Hatice Altug

This Review discusses the progresses in label-free nanophotonic biosensors based on photonic or dielectric surfaces and metasurfaces and highlights the challenges and benefits of their applications in the fields of public health, well-being and biosafety. ...

Nature Portfolio2022

Engineered Absorption Enhancement and Induced Transparency in Coupled Molecular and Plasmonic Resonator Systems

Hatice Altug

Coupled plasmonic resonators have become the subject of significant research interest in recent years as they provide a route to dramatically enhanced light-matter interactions. Often, the design of these coupled mode systems draws intuition and inspiratio ...

2013

Deep learning augmented nanoplasmonic infrared sensor for structural protein biomarker-based detection of neurodegenerative diseases

Hilal Lashuel, Hatice Altug, Rajasekhar Kolla, Deepthy Kavungal, Pedro José Santana Ribeiro Magalhães, Senthil Kumar Thangaraj

We introduce an infrared metasurface sensor based on plasmonic surface-enhanced infrared absorption spectroscopy combined with immunoassay, which detects alpha-synuclein, an early structural biomarker protein for neurodegenerative diseases with clinical sp ...

SPIE2024

Challenges and perspectives of CRISPR-based technology for diagnostic applications

Stefano Del Giovane, Hatice Altug

The precision and versatility of CRISPR-based techniques, combined with the advantages of nucleic acid-based nanotechnology, hold great promise in transforming the landscape of molecular diagnostics. While significant progress has been made, current CRISPR ...

Elsevier Sci Ltd2024

Engineering mid-infrared nanoantennas for surface enhanced infrared absorption spectroscopy

Hatice Altug

Mid-infrared absorption spectroscopy is a powerful tool for optically probing the molecular structure of biological samples. However, using conventional approaches, IR measurements on small quantities of molecules are extremely challenging due to sensitivi ...

Elsevier2015

Breaking Lorentz reciprocity to overcome the time-bandwidth limit in physics and engineering

Hatice Altug, Kosmas Tsakmakidis

A century-old tenet in physics and engineering asserts that any type of system, having bandwidth Delta omega, can interact with a wave over only a constrained time period Delta t inversely proportional to the bandwidth (Delta t-Delta w similar to 2 pi). Th ...

American Association for the Advancement of Science2017

Double-layer graphene for enhanced tunable infrared plasmonics

Hatice Altug, Andreas Tittl, Daniel Rodrigo Lopez

Graphene is emerging as a promising material for photonic applications owing to its unique optoelectronic properties. Graphene supports tunable, long-lived and extremely confined plasmons that have great potential for applications such as biosensing and op ...

Chinese Acad Sciences, Changchun Inst Optics Fine Mechanics And Physics2017

Multiplexed nanoplasmonic biosensor for one-step simultaneous detection of Chlamydia trachomatis and Neisseria gonorrhoeae in urine

Hatice Altug, Andrea Cavallini, Alexander Belushkin, Maria Soler Aznar

Development of rapid and multiplexed diagnostic tools is a top priority to address the current epidemic problem of sexually transmitted diseases. Here we introduce a novel nanoplasmonic biosensor for simultaneous detection of the two most common bacterial ...

2017