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Hatice Altug

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Publications associées (123)

Nanoplasmonic Single-Tumoroid Microarray for Real-Time Secretion Analysis

Hatice Altug, Yen-Cheng Liu, Nicolas Antoine Vincent Broguiere, Saeid Ansaryan, Luis Francisco Lorenzo Martin

Organoid tumor models have emerged as a powerful tool in the fields of biology and medicine as such 3D structures grown from tumor cells recapitulate better tumor characteristics, making these tumoroids unique for personalized cancer research. Assessment o ...

2024

Spectral Tuning of High-Harmonic Generation with Resonance-Gradient Metasurfaces

Hatice Altug, Felix Ulrich Richter

High-index dielectric subwavelength structures and metasurfaces are capable of enhancing light-matter interaction by orders of magnitude via geometry-dependent optical resonances. This enhancement, however, comes with a fundamental limitation of a narrow s ...

Wiley-V C H Verlag Gmbh2023

High-throughput spatiotemporal monitoring of single-cell secretions via plasmonic microwell arrays

Hatice Altug, Yen-Cheng Liu, Saeid Ansaryan

Methods for the analysis of cell secretions at the single-cell level only provide semiquantitative endpoint readouts. Here we describe a microwell array for the real-time spatiotemporal monitoring of extracellular secretions from hundreds of single cells i ...

NATURE PORTFOLIO2023

Plasmon-enhanced circular dichroism spectroscopy of chiral drug solutions

Hatice Altug

We investigate the potential of surface plasmon polaritons at noble metal interfaces for surface-enhanced chiroptical sensing of dilute chiral drug solutions with nl volume. The high quality factor of surface plasmon resonances in both Otto and Kretschmann ...

Aip Publishing2023

Metasurface-Enhanced Infrared Spectroscopy: An Abundance of Materials and Functionalities

Hatice Altug, Andreas Tittl, Aurélian Michel John-Herpin, Felix Ulrich Richter

Infrared spectroscopy provides unique information on the composition and dynamics of biochemical systems by resolving the characteristic absorption fingerprints of their constituent molecules. Based on this inherent chemical specificity and the capability ...

Wiley-V C H Verlag Gmbh2023

Rainbow dielectric metasurfaces for tunable resonant generation of high harmonics

Hatice Altug, Felix Ulrich Richter

We design high-Q metasurfaces with resonant wavelengths in mid-IR varying continuously along the sample. We demonstrate tunable rainbow generation of high harmonics as we vary the pump wavelength and the coordinate along the metasurface. ...

Optical Society of America2023

Dielectric Tetramer Nanoresonators Supporting Strong Superchiral Fields for Vibrational Circular Dichroism Spectroscopy

Hatice Altug, Yasaman Jahani, Bang Hyun Lee, Ming-Lun Tseng, Rui Lu, Longfang Ye, Felix Ulrich Richter

Chirality (C) is a fundamental property of objects, in terms of symmetry. It is extremely important to sense and distinguish chiral molecules in the fields of biochemistry, science, and medicine. Vibrational circular dichroism (VCD) spectroscopy, obtained ...

Amer Chemical Soc2023

Antenna-coupled infrared nanospectroscopy of intramolecular vibrational interaction

Felipe Herrera, Hatice Altug, Aurélian Michel John-Herpin

Many photonic and electronic molecular properties, as well as chemical and biochemical reactivities are controlled by fast intramolecular vibrational energy redistribution (IVR). This fundamental ultrafast process limits coherence time in applications from ...

National Academy of Sciences2023

Artificial intelligence-coupled plasmonic infrared sensor for detection of structural protein biomarkers in neurodegenerative diseases

Hilal Lashuel, Hatice Altug, Deepthy Kavungal, Rajasekhar Kolla, Pedro José Santana Ribeiro Magalhães

Diagnosis of neurodegenerative disorders (NDDs) including Parkinson's disease and Alzheimer's disease is challenging owing to the lack of tools to detect preclinical biomarkers. The misfolding of proteins into oligomeric and fibrillar aggregates plays an i ...

AMER ASSOC ADVANCEMENT SCIENCE2023

Molecular profiling of tumor-specific cytolytic CD4 T cells in human cancer

Hatice Altug, Xiaokang Li, Yen-Cheng Liu, Xuan Li

WILEY2022

Real-time monitoring of single-cell secretion with a high-throughput nanoplasmonic microarray

Hatice Altug, Xiaokang Li, Yen-Cheng Liu, Eduardo Romero Arvelo, Saeid Ansaryan

Proteins secreted by cells play significant roles in mediating many physiological, developmental, and pathological processes due to their functions in intra/intercellular communication and signaling. Conventional end-point methods are insufficient for unde ...

Elsevier2022

Advances and applications of nanophotonic biosensors

Hatice Altug

This Review discusses the progresses in label-free nanophotonic biosensors based on photonic or dielectric surfaces and metasurfaces and highlights the challenges and benefits of their applications in the fields of public health, well-being and biosafety. ...

Nature Portfolio2022

Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer

David Gfeller, Georg Alexander Rockinger, Pedro Romero, Amélie Cachot, Hatice Altug, Margaux Saillard, Xiaokang Li, George Coukos, Yen-Cheng Liu, Alexandre Harari, Alexander Mathis

CD4 T cells have been implicated in cancer immunity for their helper functions. Moreover, their direct cytotoxic potential has been shown in some patients with cancer. Here, by mining single-cell RNA-seq datasets, we identified CD4 T cell clusters displayi ...

2021

Infrared Metasurfaces Augmented by Artificial Intelligence for Monitoring Dynamics between All Major Classes of Biomolecules

Hatice Altug, Aurélian Michel John-Herpin, Deepthy Kavungal

IEEE2021

Wafer‐Scale Functional Metasurfaces for Mid‐Infrared Photonics and Biosensing

Hatice Altug, Aurélian Michel John-Herpin, Aleksandrs Leitis, Ming-Lun Tseng

Metasurfaces have emerged as a breakthrough platform for manipulating light at the nanoscale and enabling on-demand optical functionalities for next-generation biosensing, imaging, and light-generating photonic devices. However, translating this technology ...

Wiley2021

Programmable Huygens' metasurfaces for active optical phase control

Hatice Altug, Andreas Tittl, Aleksandrs Leitis

IEEE2021

Dielectric Metasurfaces Enabling Advanced Optical Biosensors

Hatice Altug, Aleksandrs Leitis, Ming-Lun Tseng

Dielectric metasurfaces have emerged as a powerful platform for novel optical biosensors. Due to their low optical loss and strong light-matter interaction, they demonstrate several exotic optical properties, including sharp resonances, strong nearfield en ...

2021

Nanophotonic biosensors harnessing van der Waals materials

Hatice Altug

Low-dimensional van der Waals (vdW) materials can harness tightly confined polaritonic waves to deliver unique advantages for nanophotonic biosensing. The reduced dimensionality of vdW materials, as in the case of two-dimensional graphene, can greatly enha ...

Nature Research2021

Imaging-based spectrometer-less optofluidic biosensors based on dielectric metasurfaces for detecting extracellular vesicles

Michele De Palma, Hatice Altug, Chiara Cianciaruso, Filiz Yesilköy, Yasaman Jahani, Eduardo Romero Arvelo

Biosensors are indispensable tools for public, global, and personalized healthcare as they provide tests that can be used from early disease detection and treatment monitoring to preventing pandemics. We introduce single-wavelength imaging biosensors capab ...

Nature Research2021

All-dielectric Metasurfaces Enabling Imaging-based Real-time Biosensing

Michele De Palma, Hatice Altug, Chiara Cianciaruso, Yasaman Jahani, Eduardo Romero Arvelo

IEEE2021

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