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Beat Fierz

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Related publications (58)

Revealing chromatin organization in metaphase chromosomes

The local structural organization of chromatin in mitotic chromosomes is not well understood. A new cryo-electron tomography study from the Daban laboratory (Chicano et al, ) reveals that mitotic chromatin isolated from human cells can assume a plate-like ...

WILEY2019

Single-molecule dynamics and genome-wide transcriptomics reveal that NF-kB (p65)-DNA binding times can be decoupled from transcriptional activation

Suliana Manley, Aleksandr Benke, Beat Fierz, Andrea Callegari, David Michael Suter, Christian Sieben

Transcription factors (TFs) regulate gene expression in both prokaryotes and eukaryotes by recognizing and binding to specific DNA promoter sequences. In higher eukaryotes, it remains unclear how the duration of TF binding to DNA relates to downstream tran ...

2019

Chromatin Remodeling Induced by the Invasion of Yeast Pioneer Transcription Factor Rap1 Revealed by Single-Molecule FRET

Louise Catherine Bryan, Maxime Nicolas Mivelaz, Beat Fierz, Iuliia Boichenko, Anne-Marinette Thi Phuong Hanh Cao

CELL PRESS2019

Biophysics of Chromatin Dynamics

Beat Fierz

Nucleosomes and chromatin control eukaryotic genome accessibility and thereby regulate DNA processes, including transcription, replication, and repair. Conformational dynamics within the nucleosome and chromatin structure play a key role in this regulatory ...

ANNUAL REVIEWS2019

Engineered Multivalent Sensors to Detect Coexisting Histone Modifications in Living Stem Cells

Horst Pick, Cédric Deluz, Bart Deplancke, Aurore Marie-France Delachat, Nora Guidotti, Beat Fierz, David Michael Suter, Antonio Carlos Alves Meireles Filho, Carolin Christine Lechner, Andreas Linus Bachmann

2018

Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α

Louise Catherine Bryan, Beat Fierz, Sinan Kilic, Iuliia Boichenko

The dynamic architecture of chromatin fibers, a key determinant of genome regulation, is poorly understood. Here, we employ multimodal single-molecule Förster resonance energy transfer studies to reveal structural states and their interconversion kinetics ...

Nature Research2018

A bi-terminal protein ligation strategy to probe chromatin structure during DNA damage

Beat Fierz, Sinan Kilic, Carolin Christine Lechner, Iuliia Boichenko

The cellular response to DNA damage results in a signaling cascade that primes chromatin for repair. Combinatorial post-translational modifications (PTMs) play a key role in this process by altering the physical properties of chromatin and recruiting downs ...

2018

Dynamic chromatin technologies: from individual molecules to epigenomic regulation in cells

Beat Fierz

The establishment and maintenance of chromatin states involves multiscale dynamic processes integrating transcription factor and multiprotein effector dynamics, cycles of chemical chromatin modifications, and chromatin structural organization. Recent devel ...

Nature Publishing Group2017

DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation

Beat Fierz, Andreas Linus Bachmann

Polycomb repressive complex 2 (PRC2) trimethylates histone H3 at lysine 27 to mark genes for repression. We measured the dynamics of PRC2 binding on recombinant chromatin and free DNA at the single-molecule level using total internal reflection fluorescenc ...

Nature Publishing Group2017

Single-molecule kinetic analysis of HP1-chromatin binding reveals a dynamic network of histone modification and DNA interactions

Vassily Hatzimanikatis, Louise Catherine Bryan, Georg Fantner, Pascal Damian Odermatt, Oliver Hantschel, Sandrine Madeleine Suzanne Georgeon, Beat Fierz, Sinan Kilic, Carolin Christine Lechner, Andreas Linus Bachmann, Daniel Robert Weilandt

Chromatin recruitment of effector proteins involved in gene regulation depends on multivalent interaction with histone post-translational modifications (PTMs) and structural features of the chromatin fiber. Due to the complex interactions involved, it is c ...

Oxford University Press (OUP)2017

A two-state activation mechanism controls the histone methyltransferase Suv39h1

Beat Fierz

Specialized chromatin domains contribute to nuclear organization and regulation of gene expression. Gene-poor regions are di- and trimethylated at lysine 9 of histone H3 (H3K9me2 and H3K9me3) by the histone methyltransferase Suv39h1. This enzyme harnesses ...

Nature Publishing Group2016

Dynamic Chromatin Regulation from a Single Molecule Perspective

Beat Fierz

Chromatin regulatory processes, like all biological reactions, are dynamic and stochastic in nature but can give rise to stable and inheritable changes in gene expression patterns. A molecular understanding of those processes is key for fundamental biologi ...

American Chemical Society2016

Traceless Synthesis of Asymmetrically Modified Bivalent Nucleosomes

Beat Fierz, Carolin Christine Lechner, Ninad Dilip Agashe

Nucleosomes carry extensive post-translational modifications (PTMs), which results in complex modification patterns that are involved in epigenetic signaling. Although two copies of each histone coexist in a nucleosome, they may not carry the same PTMs and ...

Wiley-VCH Verlag GmbH2016

2016 International Symposium on Chemical Biology of the NCCR Chemical Biology Campus Biotech, Geneva 13-15.1.2016

Oliver Hantschel, Beat Fierz

Schweizerische Chemische Gesellschaft2016

Heterochromatin Assembly and Dynamics on the Single Molecule Level

Louise Catherine Bryan, Beat Fierz, Sinan Kilic

Cell Press2015

Multivalency governs HP1α association dynamics with the silent chromatin state

Louise Catherine Bryan, Beat Fierz, Sinan Kilic, Andreas Linus Bachmann

Multivalent interactions between effector proteins and histone post-translational modifications are an elementary mechanism of dynamic chromatin signalling. Here we elucidate the mechanism how heterochromatin protein 1α (HP1α), a multivalent effector, is e ...

Nature Research2015

Molecular and Chemical Mechanism in Epigenetics – Swiss Summer School 2015 July 12–17, 2015, Hotel Kurhaus, Arolla, Switzerland

Louise Catherine Bryan, Beat Fierz, Andreas Linus Bachmann

Swiss Chemical Soc2015

Chromatin as a Dynamic Platform for Protein-Protein Interactions

Beat Fierz

Cell Press2014

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