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Beat Fierz

Cette personne a quitté l’EPFL

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Publications associées (58)

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Chromatin as a Dynamic Platform for Protein-Protein Interactions

Beat Fierz

Cell Press2014

Revealing chromatin-specific functions of histone deacylases

Beat Fierz, Carlos Moreno Yruela

Histone deacylases are erasers of Nε-acyl-lysine post-translational modifications and have been targeted for decades for the treatment of cancer, neurodegeneration and other disorders. Due to their relatively promiscuous activity on peptide substrates in v ...

2024

Gene control with a "twist": Exploring the dynamic chromatin landscape Gene control with a "twist": Exploring the dynamic chromatin landscape

Beat Fierz

SPRINGER2019

Semisynthesis of Isomerized Histone H4 Reveals Robustness and Vulnerability of Chromatin toward Molecular Aging

Beat Fierz

Proteins are subject to aging in the form of spontaneous, nonenzymatic post-translational modifications (PTMs). One such PTM is the formation of the β-linked isomer l-isoaspartic acid (isoAsp) from aspartic acid (Asp) or asparagine residues, which tends to ...

2025

A Site-Specific Click Chemistry Approach to Di-Ubiquitylate H1 Variants Reveals Position-Dependent Stimulation of the DNA Repair Protein RNF168

Beat Fierz, Pauline Franz

Ubiquitylation of histone H2A at lysines 13 and 15 by the E3 ligase RNF168 plays a key role in orchestrating DNA double-strand break (DSB) repair, which is often deregulated in cancer. RNF168 activity is triggered by DSB signaling cascades, reportedly thro ...

Wiley-VCH Verlag GmbH2024

Development of a single-molecule approach to observe ubiquitination dynamics in defined chromatin states

Beat Fierz, Alexandra Teslenko

CELL PRESS2022

Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α

Beat Fierz, Louise Catherine Bryan, Sinan Kilic, Iuliia Boichenko

The dynamic architecture of chromatin fibers, a key determinant of genome regulation, is poorly understood. Here, we employ multimodal single-molecule Förster resonance energy transfer studies to reveal structural states and their interconversion kinetics ...

Nature Research2018

The HP1 box of KAP1 organizes HP1α for silencing of endogenous retroviral elements in embryonic stem cells

Matteo Dal Peraro, Beat Fierz, Rudolf Hovius, Maria Josefina Marcaida Lopez

Repression of endogenous retroviral elements (ERVs) is facilitated by KAP1 (KRAB-associated protein 1)-containing complexes, however the underlying mechanism remains unclear. Here, we show that binding of KAP1 to the major component of the heterochromatin ...

Springer Science and Business Media LLC2025

Synthesis of Fluorescent Cyclic Peptides via Gold(I)-Catalyzed Macrocyclization

Jérôme Waser, Aleksandra Radenovic, Beat Fierz, Nathan Cyprien Arsène Ronceray, Xingyu Liu, Wei Cai

Rapid and efficient cyclization methods that form structurally novel peptidic macrocycles are of high importance for medicinal chemistry. Herein, we report the first gold(I)-catalyzed macrocyclization of peptide-EBXs (ethynylbenziodoxolones) via C2-Trp C–H ...

2023

Beat Fierz

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Chromatin as a Dynamic Platform for Protein-Protein Interactions

Revealing chromatin-specific functions of histone deacylases

Gene control with a "twist": Exploring the dynamic chromatin landscape Gene control with a "twist": Exploring the dynamic chromatin landscape

Semisynthesis of Isomerized Histone H4 Reveals Robustness and Vulnerability of Chromatin toward Molecular Aging

A Site-Specific Click Chemistry Approach to Di-Ubiquitylate H1 Variants Reveals Position-Dependent Stimulation of the DNA Repair Protein RNF168

Development of a single-molecule approach to observe ubiquitination dynamics in defined chromatin states

Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α

The HP1 box of KAP1 organizes HP1α for silencing of endogenous retroviral elements in embryonic stem cells

Synthesis of Fluorescent Cyclic Peptides via Gold(I)-Catalyzed Macrocyclization

Development of a single-molecule approach to observe ubiquitination dynamics in defined chromatin states

Short talk Single-molecule enzymology of chromatin ubiquitination

Chromatin Remodeling Induced by the Invasion of Yeast Pioneer Transcription Factor Rap1 Revealed by Single-Molecule FRET

Multiplexed single-molecule experiments reveal Cas9 nucleosome invasion dynamics

2016 International Symposium on Chemical Biology of the NCCR Chemical Biology Campus Biotech, Geneva 13-15.1.2016

Revealing dynamic chromatin invasion by pioneer transcription factors on the single-molecule scale

A single-molecule multiplexed approach to study Cas9 nucleosomes invasion

Heterochromatin Assembly and Dynamics on the Single Molecule Level

Target search dynamics of Sox transcription factors