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Nicolai Cramer

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Related publications (113)

Page 5 of 6

Generation of Heteroatom Stereocenters by Enantioselective C-H Functionalization

Nicolai Cramer, Johannes Diesel

C-H functionalization has been established as an efficient way to generate molecular complexity. The formation of stereogenic carbon atoms by asymmetric C-H functionalization has seen tremendous progress over the past decade. More recently, the direct cata ...

2019

Chiral Cyclopentadienyl Ruthenium Complexes as Versatile Catalysts for Enantioselective Transformations

Nicolai Cramer, David Kossler

Ruthenium complexes, in particular cyclopentadienyl ruthenium (II) derivatives, catalyze a vast number of transformations in the field of homogenous catalysis. Herein we describe the first synthesis of efficient chiral cationic cyclopentadienyl ruthenium ( ...

Schweizerische Chemische Gesellschaft2017

Chiral Monodentate Phosphines and Bulky Carboxylic Acids: Cooperative Effects in Palladium-Catalyzed Enantioselective C(sp3)-H Functionalization

Nicolai Cramer, Tanguy Jean Daniel Saget, Sébastien José Lemouzy

Wiley-VCH Verlag GmbH2012

Ketene Aminal Phosphates: Competent Substrates for Enantioselective Pd(0)-Catalyzed C-H Functionalizations

Nicolai Cramer, Daria Grosheva

Enantioselective Pd(0)-catalyzed C-H functionalizations of ketene aminal phosphates provide isoindoline scaffolds with high enantioselectivity at ambient temperature. The high level of enantiocontrol is enabled by a tailored monodentate electron-rich phosp ...

2017

Access to P- and Axially Chiral Biaryl Phosphine Oxides by Enantioselective (CpIrIII)-Ir-x-Catalyzed C-H Arylations

Nicolai Cramer, Julia Pedroni, Yun-Suk Jang, Lukasz Piotr Wozniak

An enantioselective C-H arylation of phosphine oxides with o-quinone diazides catalyzed by an iridium(III) complex bearing an atropchiral cyclopentadienyl (Cp-x) ligand and phthaloyl tert-leucine as co-catalyst is reported. The method allows access to a) P ...

Wiley-VCH Verlag GmbH2018

Enantioselective Cobalt(III)-Catalyzed [4 + 1] Annulation of Benzamides: Cyclopropenes as One-Carbon Synthons

Lenin Kumar Verdhi, Nicolai Cramer, Matthew Wodrich

A chiral cyclopentadienyl cobalt(III)-catalyzed enantioselective [4 + 1] annulation of N-chlorobenzamides with cyclopropenes is reported. The cobalt catalyst engages in the C−H activation as well as promotes the C−C bond cleavage of the cyclopropene, rende ...

American Chemical Society (ACS)2025

A Chiral Naphthyridine Diimine Ligand Enables Nickel‐Catalyzed Asymmetric Alkylidenecyclopropanations

Nicolai Cramer, Elena Braconi

A novel class of chiral naphthyridine diimine ligands (NDI*) readily accessible from C2‐symmetric 2,6‐di‐(1‐arylethyl)anilines is described. The utility of these ligands, particularly one with fluorinated aryl side arms, is demonstrated by a reductive Ni‐c ...

Wiley-VCH Verlag GmbH2020

Access to beta-Lactams by Enantioselective Palladium(0)-Catalyzed C(sp(3))-H Alkylation

Nicolai Cramer, Tanguy Jean Daniel Saget, Julia Pedroni, Michele Boghi

beta-Lactams are very important structural motifs because of their broad biological activities as well as their propensity to engage in ring-opening reactions. Transitionmetal- catalyzed C-H functionalizations have emerged as strategy enabling yet uncommon ...

Wiley-Blackwell2014

An Enantioselective Cp x Rh(III)‐Catalyzed C−H Functionalization/Ring‐Opening Route to Chiral Cyclopentenylamines

Nicolai Cramer, Shouguo Wang

A chiral CpxRhIII catalyst system in situ generated from a CpxRhI(cod) precatalyst and bis(o‐toluoyl) peroxide as activating oxidant was developed for a C−H activation/ring‐opening sequence between aryl ketoxime ethers and 2,3‐diazabicyclo[2.2.1]hept‐5‐ene ...

Wiley-VCH Verlag GmbH2019

Swiss CAT plus , a Data-driven Infrastructure for Accelerated Catalysts Discovery and Optimization

Elisa Clerc, Urielle Marine Randrianarisoa, Nicolai Cramer, Pascal Miéville, Florian Patrick Marie Daniel De la Barre De Nanteuil, Edy Mariano, Keyan Michel Villat, Jean-Charles Louis André Cousty

The Catalysis Hub - Swiss CAT+, is a new infrastructure project funded by the ETH Domain, co -head-ed by EPFL and ETHZ. It offers the scientific community a unique integrated technology platform combining automated and high-throughput experimentation with ...

SWISS CHEMICAL SOC2023

Biomimetic Synthesis of (+)-Ledene, (+)-Viridiflorol, (-)-Palustrol, (+)-Spathulenol, and Psiguadial A, C, and D via the Platform Terpene (+)-Bicyclogermacrene

Nicolai Cramer

(+)-Bicyclogermacrene is a strained bicyclic and common sesquiterpene found in several essential oils. A short and good yielding synthesis of bicyclogermacrene proceeding in seven steps is reported. This terpene is used as key platform intermediate for a b ...

Wiley-V C H Verlag Gmbh2014

Ligand-Controlled Regiodivergent Nickel-Catalyzed Annulation of Pyridones

Nicolai Cramer, Pavel Alexandrovich Donets

The 1,6-annulated 2-pyridone motif is found in many biologically active compounds and its close relation to the indolizidine and quinolizidine alkaloid core makes it an attractive building block. A nickel-catalyzed CH functionalization of 2-pyridones and s ...

Wiley-VCH Verlag GmbH2015

Chiral N-Heterocyclic Carbene Ligand Enabled Nickel(0)-Catalyzed Enantioselective Three-Component Couplings as Direct Access to Silylated Indanols

Nicolai Cramer, Joachim Sven Ernst Ahlin

An enantioselective nickel(0)-catalyzed reductive three-component coupling between aromatic aldehydes, norbornenes, and silanes affords directly silyl-protected indanol derivatives. A new bulky chiral C-2-symmetric NHC (NHC = N-heterocyclic carbene) ligand ...

American Chemical Society2016

Rhodium-Catalyzed Dynamic Kinetic Asymmetric Transformations of Racemic Allenes by the [3+2] Annulation of Aryl Ketimines

Nicolai Cramer

Wiley-VCH Verlag GmbH2013

Asymmetric Catalysis Powered by Chiral Cyclopentadienyl Ligands

Nicolai Cramer, David Kossler, Christopher Gordon Newton

Application of chiral derivatives of the versatile and ubiquitous cyclopentadienyl ligand has long remained an underdeveloped area in asymmetric catalysis. In this Perspective we highlight recent exciting results that demonstrate their enormous potential. ...

American Chemical Society2016

Divergent Synthesis of Densely Substituted Arenes and Pyridines via Cyclotrimerization Reactions of Alkynyl Triazenes

Kay Severin, Nicolai Cramer, Carl Thomas Bormann, Jin Fay Tan, Florian Gérald Abela, Frederick Mark Chadwick

Densely substituted fused aromatic triazenes can be prepared by [2 + 2 + 2] cyclotrimerization reactions of 1-alkynyl triazenes. The Cp*Ru-catalyzed cyclization proceeds well with both simple alkynyl triazenes and tethered 1-diynyl triazenes. Attractively, ...

2019

Access to Sultams by Rhodium(III)-Catalyzed Directed C-H Activation

Nicolai Cramer, Baihua Ye, Van Manh Pham

Wiley-VCH Verlag GmbH2012

Chiral Monodentate Trialkylphosphines Based on the Phospholane Architecture

Nicolai Cramer, Tanguy Jean Daniel Saget, Pavel Alexandrovich Donets

The development of efficient chiral monodentate phosphine ligands lags behind that of the bidentate congeners. This holds especially true for highly electron rich chiral phosphine analogues able to replace the ubiquitous tricyclohexylphosphine and tri-tert ...

Amer Chemical Soc2012

Atropo‐Enantioselective Oxidation‐Enabled Iridium(III)‐Catalyzed C−H Arylations with Aryl Boronic Esters

Nicolai Cramer, Lukasz Piotr Wozniak

Atropo-enantioselective biaryl coupling through C−H bond functionalization is an emerging technology allowing direct construction of axially chiral molecules. This approach is largely limited to electrophilic coupling partners. We report a highly atropo-en ...

Wiley-VCH Verlag GmbH2021

Catalytic enantioselective reductive Eschenmoser-Claisen rearrangements

Nicolai Cramer, Matthew Wodrich, Guoting Zhang

An important challenge in enantioselective catalysis is developing strategies for the precise synthesis of neighboring congested all-carbon quaternary stereocenters. The well-defined transition states of [3,3]-sigmatropic rearrangements and their underlyin ...

American Association for the Advancement of Science2024