Publication

A Chiral Naphthyridine Diimine Ligand Enables Nickel‐Catalyzed Asymmetric Alkylidenecyclopropanations

Nicolai Cramer, Elena Braconi
2020
Journal Articles

Abstract

A novel class of chiral naphthyridine diimine ligands (NDI*) readily accessible from C2‐symmetric 2,6‐di‐(1‐arylethyl)anilines is described. The utility of these ligands, particularly one with fluorinated aryl side arms, is demonstrated by a reductive Ni‐catalyzed enantioselective alkylidene transfer reaction from 1,1‐dichloroalkenes to olefins. This transformation provides direct access to a broad range of synthetically valuable alkylidenecyclopropanes in high yields and enantioselectivities.

Official source

https://infoscience.epfl.ch/entities/publication/8cec09a9-9171-48ed-99ce-f1e992d5c275

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