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Related publications (297)

Implantable devices: the future of blood monitoring? (Editorial)

Giovanni De Micheli, Cristina Boero, Sandro Carrara

Implantable devices can be developed for the simultaneous monitoring of a specific group of key metabolites, identified by more complex techniques, such as mass spectroscopy- or nuclear magnetic -based analysis.. Since there is a strong correlation between ...

2013

An Implantable Bio-Micro-system for Drug Monitoring

Catherine Dehollain, Giovanni De Micheli, Sandro Carrara, Enver Gürhan Kilinç, Camilla Baj-Rossi, Seyedeh Sara Ghoreishizadeh

Multi-target and continuous monitoring by wireless implantable devices is of increasing interest for personalized therapy. In this work an implantable system is presented which is capable of measuring different drugs with Cyclic Voltammetry (CV) method. Th ...

2013

Fabrication and Packaging of a Fully Implantable Biosensor Array

Catherine Dehollain, Giovanni De Micheli, Sandro Carrara, Enver Gürhan Kilinç, Camilla Baj-Rossi, Seyedeh Sara Ghoreishizadeh, Daniele Casarino

In this work, we showed the realization of a fully- implantable device that integrates a microfabricated sensing platform, a coil for power and data transmission and integrated circuits. We described a device intended to test the biocompati- bility of the ...

2013

Empirical Study of Noise Dependence in Electrochemical Sensors

Giovanni De Micheli, Sandro Carrara, Seyedeh Sara Ghoreishizadeh

We report the experimental study of noise in electrochemical biosensors as related to voltage and concentration. A comparison with experiments is performed for H2O2 and Ferrocyanide with bare sensors and with sensors functionalized wi ...

2013

A Study of Multi-Layer Spiral Inductors for Remote Powering of Implantable Sensors

Giovanni De Micheli, Sandro Carrara, Jacopo Olivo

An approach based on multi-layer spiral inductors to remotely power implantable sensors is investigated. As compared to single-layer inductors having the same area, multi-layer printed inductors enable a higher efficiency (up to 35% higher) and voltage gai ...

Ieee-Inst Electrical Electronics Engineers Inc2013

Direct growth of nanotubes and graphene nanoflowers on electrochemical platinum electrodes

László Forró, Arnaud Magrez, Giovanni De Micheli, Sandro Carrara, Irene Taurino, Federico Matteini

Multi-walled carbon nanotubes and graphene nanoflowers were grown by a catalytic chemical vapor deposition process on metal surfaces. Electrodeposition was used as a versatile technique to obtain three different iron catalyst coatings on platinum microelec ...

2013

Comparative study of three lactate oxidases from Aerococcus viridans for biosensing applications

Giovanni De Micheli, Sandro Carrara, Irene Taurino

A comparison between engineered and commercially available L-lactate oxidases from Aerococcus viridans was conducted for biosensing applications. Enzymes were adsorbed onto the surfaces of graphite electrodes modified with multi-walled carbon nanotubes. Th ...

Elsevier2013

NutriChip: Nutrition Analysis meets Microfluidics

Martinus Gijs, Paolo Silacci, Guy Vergères, Gözen Köklü, Julien Michel Ghaye, Sandro Carrara, Hamideh Jafarpoorchekab, Christine Ruffert

This focus article introduces the concept of NutriChip, an integrated microfluidic platform for investigating the potential of the immuno-modulatory function of dairy food. The core component of the NutriChip is a miniaturized artificial human gastrointest ...

Royal Society of Chemistry2013

Empowering Low-Cost CMOS Cameras by Image Processing to Reach Comparable Results with Costly CCDs

Yusuf Leblebici, Giovanni De Micheli, Gözen Köklü, Julien Michel Ghaye, Sandro Carrara

Despite the huge research effort to improve the performance of the complementary metal oxide semiconductor (CMOS) image sensors, charge-coupled devices (CCDs) still dominate the cell biology-related conventional fluorescence microscopic imaging market wher ...

2013

The NutriChip project - translating technology into nutritional knowledge

Martinus Gijs, Paolo Silacci, Guy Vergères, Sandro Carrara, Flurina Schwander, Reto Portmann

Advances in food transformation have dramatically increased the diversity of products on the market and, consequently, exposed consumers to a complex spectrum of bioactive nutrients whose potential risks and benefits have mostly not been confidently demons ...

Cambridge University Press2012

Quantitative Comparison of Commercial CCD and Custom-Designed CMOS Camera for Biological Applications

René Beuchat, Yusuf Leblebici, Giovanni De Micheli, Gözen Köklü, Julien Michel Ghaye, Sandro Carrara

In biological applications and systems where even the smallest details have a meaning, CCD cameras are mostly preferred and they hold most of the market share despite their high costs. In this paper, we propose a custom-designed CMOS camera to compete with ...

2012

New Approaches for Carbon Nanotubes-Based Biosensors and Their Application to Cell Culture Monitoring

Giovanni De Micheli, Cristina Boero, Sandro Carrara, Jacopo Olivo

Amperometric biosensors are complex systems and they require a combination of technologies for their development. The aim of the present work is to propose a new approach in order to develop nanostructured biosensors for the real-time detection of multiple ...

Ieee-Inst Electrical Electronics Engineers Inc2012

Quantification of Sub-resolution Sized Targets in Cell Fluorescent Imaging

Giovanni De Micheli, Julien Michel Ghaye, Sandro Carrara

We introduce two methods for quantifying and evaluating the amount of surface receptors within a group of cells from fluorescence microscope images. First, the average fluorescence intensity method (AFIM), based on the fluores- cent pixels average intensit ...

2012

Integrated Biosensors for Personalized Medicine

Giovanni De Micheli, Cristina Boero, Sandro Carrara, Irene Taurino, Camilla Baj-Rossi

Biosensors are heterogenous devices, incorporating biological struc- tures combined with electronics, optical or other readout systems. They have been developed for detecting different biomolecules and/or pathogens and represent a key technology for advanc ...

Ieee2012

Simulated biological cells for receptor counting in fluorescence imaging

Giovanni De Micheli, Julien Michel Ghaye, Sandro Carrara

Digital image processing and epi-fluorescence microscopy provide one of the main and basic tools for living biological cells analysis and studying. Developing, testing and comparing those image processing methods properly require the use of a controlled en ...

2012

Multiwalled Carbon Nanotubes for Amperometric Array-Based Biosensors

Giovanni De Micheli, Sandro Carrara, Irene Taurino

For diagnostic and therapeutic purposes an accurate determination of multiple metabolites is often required. Amperometric devices are attractive tools to quantify biological compounds due to the direct conversion of a biochemical event to a current. This r ...

2012

Comparison of Two Different Carbon Nanotube-based Surfaces with Respect to Potassium Ferricyanide Electrochemistry

Giovanni De Micheli, Sandro Carrara, Irene Taurino

This paper describes the electrochemical investigation of two multi-walled carbon nanotube-based electrodes using potassium ferricyanide as a benchmark redox system. Carbon nanotubes were fabricated by chemical vapor deposition on silicon wafer with campho ...

2012

A Current-Mode Potentiostat for Multi-Target Detection Tested with Different Lactate Biosensors

Giovanni De Micheli, Sandro Carrara, Irene Taurino, Seyedeh Sara Ghoreishizadeh

Real-time and multi-target detection by wireless implantable devices is of increasing interest for chronic patients. In this work, electrode sharing is proposed to minimize the size of the implantable device when several three-electrode-based sensing sites ...

2012

Low-cost, CMOS compatible, Ta2O5-based hemi-memristor for neuromorphic circuits

Giovanni De Micheli, Sandro Carrara

In the past, tantalum oxide devices have been used to create non-volatile digital memories, whilst neglecting the analogue memristive characteristics of such devices. In this Letter, it is shown that these devices can provide a low-cost, low-power solution ...

Institution of Engineering and Technology2012

Memristive-Biosensors: A New Detection Method by Using Nanofabricated Memristors

Yusuf Leblebici, Giovanni De Micheli, Davide Sacchetto, Sandro Carrara, Camilla Baj-Rossi

This paper proposes a new detection methodology based on memristive-effect registered on silicon nanowire. The nano-wires are fabricated by a lithographic technique that allows precise and selective etching at the nanoscale. The wires are obtained in three ...

Elsevier2012

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