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Felix Schürmann

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Related publications (82)

Page 2 of 5

Preserving axosomatic spiking features despite diverse dendritic morphology

Henry Markram, Felix Schürmann, Idan Segev

Throughout the nervous system, cells belonging to a certain electrical class (e-class)-sharing high similarity in firing response properties-may nevertheless have widely variable dendritic morphologies. To quantify the effect of this morphological variabil ...

American Physiological Society2013

A Process for Digitizing and Simulating Biologically Realistic Oligocellular Networks Demonstrated for the Neuro-Glio-Vascular Ensemble

Pierre Magistretti, Henry Markram, Felix Schürmann, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Renaud Jolivet, Stefan Eilemann, Jay Coggan, Corrado Cali

One will not understand the brain without an integrated exploration of structure and function, these attributes being two sides of the same coin: together they form the currency of biological computation. Accordingly, biologically realistic models require ...

2018

CoreNEURON : An Optimized Compute Engine for the NEURON Simulator

Aleksandr Ovcharenko, Jérémy Pierre Benoit Fouriaux, Felix Schürmann, James Gonzalo King, Pramod Shivaji Kumbhar, Fabien Jonathan Delalondre

The NEURON simulator has been developed over the past three decades and is widely used by neuroscientists to model the electrical activity of neuronal networks. Large network simulation projects using NEURON have supercomputer allocations that individually ...

2019

Metaball skinning of synthetic astroglial morphologies into realistic mesh models for visual analytics and in silico simulations

Henry Markram, Felix Schürmann, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Jay Coggan, Nadir Roman Guerrero, Alessandro Enrico Foni, Samuel Lieven D. Lapere, Eleftherios Zisis

Motivation: Astrocytes, the most abundant glial cells in the mammalian brain, have an instrumental role in developing neuronal circuits. They contribute to the physical structuring of the brain, modulating synaptic activity and maintaining the blood-brain ...

Oxford University Press2021

Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part I: Anatomy

Henry Markram, Kathryn Hess Bellwald, Felix Schürmann, Daniel Keller, Eilif Benjamin Muller, Michael Reimann, Werner Alfons Hilda Van Geit, Lida Kanari, Srikanth Ramaswamy, Matthias Wolf, James Gonzalo King, Alexis Arnaudon, Ying Shi, András Ecker, Jean-Denis Georges Emile Courcol, Armando Romani, Pramod Shivaji Kumbhar, Judit Planas Carbonell, Michael Emiel Gevaert, Fernando Joaquim Leite Pereira, Liesbeth Maria L Vanherpe, Huanxiang Lu, Daniela Egas Santander, James Bryden Isbister, Ran Levi, Benoît Jean-Albert Coste, Samuel Lieven D. Lapere, Sirio Bolaños Puchet, Juan Bautista Hernando Vieites, Cyrille Pierre Henri Favreau, Joni Henrikki Herttuainen, Christoph Pokorny, Vishal Sood, Thomas Brice Delemontex, Adrien Michel Achille Devresse, Nicolas René Jean Ninin, Alexander Dietz, Hugo Thabo Dictus, Gianluca Ficarelli

The function of the neocortex is fundamentally determined by its repeating microcircuit motif, but also by its rich, hierarchical, interregional structure with a highly specific laminar architecture. The last decade has seen the emergence of extensive new ...

2024

Simulation Neurotechnologies for Advancing Brain Research: Parallelizing Large Networks in NEURON

Felix Schürmann

Large multiscale neuronal network simulations are of increasing value as more big data are gathered about brain wiring and organization under the auspices of a current major research initiative, such as Brain Research through Advancing Innovative Neurotech ...

Mit Press2016

Digital Reconstruction of the Neuro-Glia-Vascular Architecture

Henry Markram, Kathryn Hess Bellwald, Felix Schürmann, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Lida Kanari, Alexis Arnaudon, Michael Emiel Gevaert, Alessandro Enrico Foni, Benoît Jean-Albert Coste, Corrado Cali, Eleftherios Zisis, Thomas Brice Delemontex

Astrocytes connect the vasculature to neurons mediating the supply of nutrients and biochemicals. They are involved in a growing number of physiological and pathophysiological processes that result from biophysical, physiological, and molecular interaction ...

OXFORD UNIV PRESS INC2021

An Efficient Parallel Load-Balancing Framework for Orthogonal Decomposition of Geometrical Data

Felix Schürmann

The accurate subdivision of spatially organized datasets is a complex problem in computer science but specifically important for load balancing in parallel environments. The problem is to (a) find a partitioning where each partition has the same number of ...

2016

Structural to functional synaptic conversion

Henry Markram, Felix Schürmann, Sean Lewis Hill, Eilif Benjamin Muller, Michael Reimann, James Gonzalo King

Computer-implemented methods, software, and systems for determining functional synapses from given structural touches between cells in a neuronal circuit are described. One computer-implemented method for determining functional synapses from predetermined ...

Technology Transfer Office EPFL2015

Distributor of neurons in a neocortical column

Henry Markram, Felix Schürmann, Georges Khazen

Computer-implemented methods, software, and systems for determining a distribution of neuronal cells across a portion of a brain are described. One computer-implemented method for determining a target distribution of one or more neuronal cells across a por ...

2014

The quantitative single-neuron modeling competition

Wulfram Gerstner, Felix Schürmann, Richard Naud, Renaud Jolivet

As large-scale, detailed network modeling projects are flourishing in the field of computational neuroscience, it is more and more important to design single neuron models that not only capture qualitative features of real neurons but are quantitatively ac ...

Springer Verlag2008

A Component-Based Extension Framework for Large-Scale Parallel Simulations in NEURON

Henry Markram, Felix Schürmann, Sean Lewis Hill

As neuronal simulations approach larger scales with increasing levels of detail, the neurosimulator software represents only a part of a chain of tools ranging from setup, simulation, interaction with virtual environments to analysis and visualizations. Pr ...

2009

STEPS 4.0: Fast and memory-efficient molecular simulations of neurons at the nanoscale

Christos Kotsalos, Tristan Mathieu Carel, Samuel Marie A Melchior, Baudouin Paul Michel Maria Joseph Del Marmol, Giacomo Castiglioni, Nicola Cantarutti, Felix Schürmann, James Gonzalo King, Pramod Shivaji Kumbhar, Omar Awile, Alessandro Cattabiani

Recent advances in computational neuroscience have demonstrated the usefulness and importance of stochastic, spatial reaction-diffusion simulations. However, ever increasing model complexity renders traditional serial solvers, as well as naive parallel imp ...

FRONTIERS MEDIA SA2022

Towards real-time visualization of detailed neural tissue models: View frustum culling for parallel rendering

Felix Schürmann, Juan Bautista Hernando Vieites

Recent efforts to model neural tissue in great anatomical detail play an important role in the shift towards simulation-based brain research. Visualization of those detailed models is an important part of the scientific workflow, allowing domain scientists ...

IEEE2012

Intrinsic morphological diversity of thick-tufted layer 5 pyramidal neurons ensures robust and invariant properties of in silico synaptic connections

Henry Markram, Felix Schürmann, Srikanth Ramaswamy

The morphology of neocortical pyramidal neurons is not only highly characteristic but also displays an intrinsic diversity that renders each neuron morphologically unique. We investigated the significance of this intrinsic morphological diversity in in sil ...

2012

Fully-Asynchronous Cache-Efficient Simulation of Detailed Neural Networks

Felix Schürmann

Modern asynchronous runtime systems allow the re-thinking of large-scale scientific applications. With the example of a simulator of morphologically detailed neural networks, we show how detaching from the commonly used bulk-synchronous parallel (BSP) exec ...

SPRINGER INTERNATIONAL PUBLISHING AG2019

Reconstruction and visualization of large-scale volumetric models of neocortical circuits for physically-plausible in silico optical studies

Henry Markram, Felix Schürmann, Marwan Muhammad Ahmed Abdellah, Juan Bautista Hernando Vieites, Stefan Eilemann, Nicolas Antille

Background: We present a software workflow capable of building large scale, highly detailed and realistic volumetric models of neocortical circuits from the morphological skeletons of their digitally reconstructed neurons. The limitations of the existing a ...

2017

Rebasing I/O for Scientific Computing: Leveraging Storage Class Memory in an IBM BlueGene/Q Supercomputer

Alessandro Curioni, John Anthony Biddiscombe, Miguel Angel Gila Arrondo, Peter Morjan, Robert Germain, Blake Fitch, Felix Schürmann, Pramod Shivaji Kumbhar, Fabien Jonathan Delalondre, Lars Schneidenbach

Storage class memory is receiving increasing attention for use in HPC systems for the acceleration of intensive IO operations. We report a particular instance using SLC FLASH memory integrated with an IBM BlueGene/Q supercomputer at scale (Blue Gene Active ...

Springer2014

Fully implicit parallel simulation of single neurons

Henry Markram, Felix Schürmann

When a multi-compartment neuron is divided into subtrees such that no subtree has more than two connection points to other subtrees, the subtrees can be on different processors and the entire system remains amenable to direct Gaussian elimination with only ...

2008

Community-based reconstruction and simulation of a full-scale model of region CA1 of rat hippocampus

Alberto Antonietti, Davide Bella, Pranav Rai, Henry Markram, Felix Schürmann, Eilif Benjamin Muller, Michael Reimann, Marwan Muhammad Ahmed Abdellah, Werner Alfons Hilda Van Geit, Lida Kanari, Srikanth Ramaswamy, James Gonzalo King, Alexis Arnaudon, Ying Shi, András Ecker, Jean-Denis Georges Emile Courcol, Armando Romani, Pramod Shivaji Kumbhar, Judit Planas Carbonell, Michael Emiel Gevaert, Nadir Roman Guerrero, Liesbeth Maria L Vanherpe, Huanxiang Lu, Mohameth François Sy, Cristina Colangelo, Juan Bautista Hernando Vieites, Cyrille Pierre Henri Favreau, Genrich Ivaska, Anna-Kristin Kaufmann, Joni Henrikki Herttuainen, Elvis Boci, Vishal Sood, Thomas Brice Delemontex, Fabien Petitjean, Julian Martin Budd, Mustafa Kerem Kurban

The CA1 region of the hippocampus is one of the most studied regions of the rodent brain, thought to play an important role in cognitive functions such as memory and spatial navigation. Despite a wealth of experimental data on its structure and function, i ...

2024