Publications by Rolf Gruetter | EPFL Graph Search

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We advocate the use of a novel compressed sensing technique for accelerating the magnetic resonance image acquisition process, coined spread spectrum MR imaging or simply s2MRI. The method resides in pre-modulating the signal of interest by a linear chirp, ...

All 13C NMR studies of brain glycogen to date relied on observing the incorporation of 13C label into glycogen, and thus interpretation was potentially affected by changes in 13C label turnover rates. The goal of this study was to quantify total brain glyc ...

C57BL/6 mice are the most widely used strain of laboratory mice. Using in vivo proton Magnetic Resonance Spectroscopy (1H MRS), we have repeatedly observed an abnormal neurochemical profile in the brains of both wild-type and ge ...

This review covers some of the contributions to date from cerebellar imaging studies performed at ultra-high magnetic fields. A short overview of the general advantages and drawbacks of the use of such high field systems for imaging is given. One of the bi ...

Emerging evidence suggests that hierarchical status provide vulnerability to develop stress-induced depression. Energy metabolic changes in the nucleus accumbens (NAc) were recently related to hierarchical status and vulnerability to develop depression-lik ...

The BOLD contrast is widely used to study brain function. Under externally-applied stimuli, positive BOLD responses (PBR) are generally attributed to local increases in brain activity. Negative BOLD responses (NBR) are also frequently observed, but their u ...

The broad resonances underlying the entire (1) H NMR spectrum of the brain, ascribed to macromolecules, can influence metabolite quantification. At the intermediate field strength of 3 T, distinct approaches for the determination of the macromolecule signa ...

After ischemic stroke, the ischemic damage to brain tissue evolves over time and with an uneven spatial distribution. Early irreversible changes occur in the ischemic core, whereas, in the penumbra, which receives more collateral blood flow, the damage is ...

In 1H magnetic resonance spectroscopy, macromolecule signals underlay metabolite signals, the understanding of which is necessary for reliable metabolite quantification. When macromolecule signals are measured using an inversion-recovery pulse sequence, sp ...

OBJECTIVES: For turbo spin echo (TSE) sequences to be useful at ultra-high field, they should ideally employ an RF pulse train compensated for the B 1 + inhomogeneity. Previously, it was shown that a single kT-point pulse designed in the small tip-angle re ...

Clinical use of the Stejskal-Tanner diffusion weighted images is hampered by the geometric distortions that result from the large residual 3D eddy current field induced. In this work we aimed to predict, using linear response theory, the residual 3D eddy c ...

Measurement of arterial input function is a restrictive aspect for quantitative 18F-FDG PET studies in rodents because of their small total blood volume and the related difficulties in withdrawing blood. METHODS: In the present study, we took advantage of ...

The large spatial inhomogeneity in transmit B, field (B-1(+)) observable in human MR images at hi h static magnetic fields (B-0) severely impairs image quality. To overcome this effect in brain T-1-weighted images the, MPRAGE sequence was modified to gener ...

Eddy currents induced by switching of magnetic field gradients can lead to distortions in short echo-time spectroscopy or diffusion weighted imaging. In small bore magnets, such as human head-only systems, minimization of eddy current effects is more deman ...

Acetate has been proposed as an astrocyte-specific energy substrate for metabolic studies in the brain. The determination of the relative contribution of the intracellular and extracellular compartments to the acetate signal using diffusion-weighted magnet ...

Full signal intensity H-1-[C-13] NMR spectroscopy, combining a preceding C-13-editing block based on an inversion BISEP (B-1-insensitive spectral editing pulse) with a spin-echo coherence-based localization, was developed and implemented at 14.1 T. C-13 ed ...

Trapped coil designs allow the operation of lower-frequency coils in the presence of a proton coil. Adding a second capacitor to a trap in the non-proton RF coil allows control over the trap reactance at the low and high frequency (here 13C and 1H) and the ...

In vivo localized proton magnetic resonance spectroscopy (1H MRS) became a powerful and unique technique to non-invasively investigate brain metabolism of rodents and humans. The main goal of 1H MRS is the reliable quantification of concentrations of metab ...

Cerebral function is associated with exceptionally high metabolic activity, and requires continuous supply of oxygen and nutrients from the blood stream. Since the mid-20th century the idea that brain energy metabolism is coupled to neuronal activity has e ...

Rolf Gruetter

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Accelerated MR imaging with spread spectrum encoding

Biochemical quantification of total brain glycogen concentration in rats under different glycemic states

The C57BL/6J Mouse Exhibits Sporadic Congenital Portosystemic Shunts

In vivo Structural Imaging of the Cerebellum, the Contribution of Ultra-High Fields

Metabolic signature in nucleus accumbens for anti-depressant-like effects of acetyl-L-carnitine

Intra and cross-modal negative BOLD response to contrast-varying visual stimuli

Quantification of the neurochemical profile using simulated macromolecule resonances at 3 T

High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice

In vivo brain macromolecule signals in healthy and glioblastoma mouse models: 1H magnetic resonance spectroscopy, post-processing and metabolite quantification at 14.1 T

3D T 2-weighted imaging at 7T using dynamic kT-points on single-transmit MRI systems

3D Residual Eddy Current Field Characterisation: applied to Diffusion Weighted Magnetic Resonance Imaging

Image-Derived Input Function from the Vena Cava for 18F-FDG PET Studies in Rats and Mice

MP2RAGE, a self bias-field corrected sequence for improved segmentation and T-1-mapping at high field

Eddy current effects on a clinical 7T-68 cm bore scanner

Diffusion-weighted MRS of acetate in the rat brain

Hyperpolarized acetate as a metabolic tracer for skeletal and cardiac muscle energetics

H-1-[C-13] NMR Spectroscopy of the Rat Brain During Infusion of [2-C-13] Acetate at 14.1 T

Proton traps for multi-nuclear RF coils: design analysis and practical implementation for 13C MRS in humans at 7T

Handling macromolecule signals in the quantification of the neurochemical profile

How Energy Metabolism Supports Cerebral Function: Insights from 13C Magnetic Resonance Studies In vivo