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Rolf Gruetter

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Related publications (418)

GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution

Glucose, the main energy substrate used in the CNS, is continuously supplied by the periphery. Glutamate, the major excitatory neurotransmitter, is foreseen as a complementary energy contributor in the brain. In particular, astrocytes actively take up glut ...

Elsevier2015

Assessment of metabolic fluxes in the mouse brain in vivo using (1)H-[(13)C] NMR spectroscopy at 14.1 Tesla

Bernard Lanz, Rolf Gruetter, Lijing Xin, Hongxia Lei

(13)C magnetic resonance spectroscopy (MRS) combined with the administration of (13)C labeled substrates uniquely allows to measure metabolic fluxes in vivo in the brain of humans and rats. The extension to mouse models may provide exclusive prospect for t ...

Nature Publishing Group2015

Fast low-specific absorption rate B0-mapping along projections at high field using two-dimensional radiofrequency pulses

Rolf Gruetter, Benoît Schaller, Daniel Gallichan, Olivier Benoit Thomas Reynaud

Purpose At 7 Tesla (T), conventional static field (B0) projection mapping techniques, e.g., FASTMAP, FASTESTMAP, lead to elevated specific absorption rates (SAR), requiring longer total acquisition times (TA). In this work, the series of adiabatic pulses n ...

Wiley-Blackwell2015

Distinct contributions of Brodmann areas 1 and 2 to body ownership

Roberto Martuzzi, Rolf Gruetter, Olaf Blanke, Sebastian Dieguez Falcon, Wietske Van der Zwaag, Andrea Serino

Although body ownership – i.e. the feeling that our bodies belong to us – modulates activity within the primary somatosensory cortex (S1), it is still unknown whether this modulation occurs within a somatotopically defined portion of S1. We induced an illu ...

Oxford University Press2015

Prospective motion correction with FID-triggered image navigators

Jean-Philippe Thiran, Reto Meuli, Rolf Gruetter, Guillaume Bonnier, Gunnar Krüger, Tobias Kober, Tom Hilbert, Maryna Volodimirivna Waszak, Pavel Falkovskiy

2015

Energy metabolism in the rat cortex under deep thiopental anesthesia measured in vivo by 13C MRS at 14.1 T

Rolf Gruetter, João Miguel das Neves Duarte, Nathalie Just, Sarah Catherine Sonnay

Wiley-Blackwell2015

Simultaneous EEG–fMRI at ultra-high field: Artifact prevention and safety assessment

Rolf Gruetter, Wietske Van der Zwaag, João Pedro Forjaco Jorge, Patricia Figueiredo, Özlem Ipek

The simultaneous recording of scalp electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) can provide unique insights into the dynamics of human brain function, and the increased functional sensitivity offered by ultra-high field fM ...

Elsevier2015

Evidence From Imaging Studies For Oxidative Stress Mechanisms In First Episode Schizophrenia

Jean-Philippe Thiran, Patric Hagmann, Rolf Gruetter, Lijing Xin, João Miguel das Neves Duarte, Alessandra Griffa, Yohan Van de Looij, Alexander Monin, Alberto Corcoba, Kim Do

Oxford Univ Press2015

Characterization of hepatic fatty acids in mice with reduced liver fat by ultra-short echo time (1) H-MRS at 14.1 T in vivo

Rolf Gruetter, Hongxia Lei, Ana Francisca Leal Silva Soares

Alterations in the hepatic lipid content (HLC) and fatty acid composition are associated with disruptions in whole body metabolism, both in humans and in rodent models, and can be non-invasively assessed by (1) H-MRS in vivo. We used (1) H-MRS to character ...

Wiley-Blackwell2015

Non-invasive diagnostic biomarkers for estimating the onset time of permanent cerebral ischemia

Rolf Gruetter, Lijing Xin, Hongxia Lei, Corinne Benakis, Lara Buscemi Estefanell

The treatments for ischemic stroke can only be administered in a narrow time-window. However, the ischemia onset time is unknown in ~30% of stroke patients (wake-up strokes). The objective of this study was to determine whether MR spectra of ischemic brain ...

Nature Publishing Group2014

Hyperpolarized 13C lactate as a substrate for in vivo metabolic studies in skeletal muscle

Arnaud Comment, Rolf Gruetter, Josefina Adriana Maria Bastiaansen, Yuhei Takado, Hikari Ananda Infinity Yoshihara

Resting skeletal muscle has a preference for the oxidation of lipids compared to carbohydrates and a shift towards carbohydrate oxidation is observed with increasing exercise. Lactate is not only an end product in skeletal muscle but also an important meta ...

2014

Image-Derived Input Function from the Vena Cava for 18F-FDG PET Studies in Rats and Mice

Bernard Lanz, Rolf Gruetter, Carole Poitry-Yamate

Measurement of arterial input function is a restrictive aspect for quantitative 18F-FDG PET studies in rodents because of their small total blood volume and the related difficulties in withdrawing blood. METHODS: In the present study, we took advantage of ...

Soc Nuclear Medicine Inc2014

In vivo brain macromolecule signals in healthy and glioblastoma mouse models: 1H magnetic resonance spectroscopy, post-processing and metabolite quantification at 14.1 T

Rolf Gruetter, Cristina Ramona Cudalbu, Mélanie Craveiro

In 1H magnetic resonance spectroscopy, macromolecule signals underlay metabolite signals, the understanding of which is necessary for reliable metabolite quantification. When macromolecule signals are measured using an inversion-recovery pulse sequence, sp ...

Wiley-Blackwell2014

Impaired White Matter Integrity in Fornix and Anterior Commissure in a Schizophrenia Mouse Model of Redox Dysregulation

Rolf Gruetter, João Miguel das Neves Duarte, Yohan Van de Looij, Alberto Corcoba, Kim Do

Elsevier Science Inc2014

Definition and quantification of acute inflammatory white matter injury in the immature brain by MRI/MRS at high magnetic field

Nicolas Kunz, Rolf Gruetter

Background: Intrauterine growth restriction (IUGR) is a major risk factor for both perinatal and long-term morbidity. Bovine lactoferrin (bLf) is a major milk glycoprotein considered as a pleiotropic functional nutrient. The impact of maternal supplementat ...

Nature Publishing Group2014

Impact of insulin resistance on memory performance, brain morphology and neurochemical profiles of the cortex and hippocampus

Rolf Gruetter, João Miguel das Neves Duarte

Springer2014

Optimized MEGA-SPECIAL for in vivo glutamine detection in the rat brain at 14.1 T

Rolf Gruetter, Cristina Ramona Cudalbu, Mélanie Craveiro

Glutamine has multiple roles in brain metabolism and its concentration can be altered in various pathological conditions. An accurate knowledge of its concentration is therefore highly desirable to monitor and study several brain disorders in vivo. However ...

Wiley-Blackwell2014

Improved temporal resolution for functional studies with reduced number of segments with three-dimensional echo planar imaging

Rolf Gruetter, Wietske Van der Zwaag, Tobias Kober, José Pedro Rebelo Ferreira Marques, Mayur Narsude

PURPOSE: To introduce a new k-space traversal strategy for segmented three-dimensional echo planar imaging (3D EPI) that encodes two partitions per radiofrequency excitation, effectively reducing the number excitations used to acquire a 3D EPI dataset by h ...

Wiley-Blackwell2014

Experimental peripheral arterial disease: new insights into muscle glucose uptake, macrophage, and T-cell polarization during early and late stages

Rolf Gruetter, Carole Poitry-Yamate

Peripheral arterial disease (PAD) is a common disease with increasing prevalence, presenting with impaired walking ability affecting patient's quality of life. PAD epidemiology is known, however, mechanisms underlying functional muscle impairment remain un ...

2014

Improving T2 -weighted imaging at high field through the use of kT -points

Rolf Gruetter, Florent Eggenschwiler, José Pedro Rebelo Ferreira Marques, Kieran O'Brien

PURPOSE: At high magnetic field strengths (B0 >/= 3 T), the shorter radiofrequency wavelength produces an inhomogeneous distribution of the transmit magnetic field. This can lead to variable contrast across the brain which is particularly pronounced in T2 ...

Wiley-Blackwell2014

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