Publications de Rolf Gruetter | EPFL Graph Search

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A large body of published work shows that proton (hydrogen 1 [(1)H]) magnetic resonance (MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality. Herein, the authors present a summary of brain disorders in which MR spectrosc ...

Glucose supply from blood to brain occurs through facilitative transporter proteins. A near linear relation between brain and plasma glucose has been experimentally determined and described by a reversible model of enzyme kinetics. A conformational four-st ...

(13)C magnetic resonance spectroscopy (MRS) combined with the administration of (13)C labeled substrates uniquely allows to measure metabolic fluxes in vivo in the brain of humans and rats. The extension to mouse models may provide exclusive prospect for t ...

The current study investigates a new model of barrel cortex activation using stimulation of the infraorbital branch of the trigeminal nerve. A robust and reproducible activation of the rat barrel cortex was obtained following trigeminal nerve stimulation. ...

In the brain, glycogen is a source of glucose not only in emergency situations but also during normal brain activity. Altered brain glycogen metabolism is associated with energetic dysregulation in pathological conditions, such as diabetes or epilepsy. Bot ...

Schizophrenia pathophysiology implies both abnormal redox control and dysconnectivity of the prefrontal cortex, partly related to oligodendrocyte and myelin impairments. As oligodendrocytes are highly vulnerable to altered redox state, we investigated the ...

The detection of Parkinson's disease (PD) in its preclinical stages prior to outright neurodegeneration is essential to the development of neuroprotective therapies and could reduce the number of misdiagnosed patients. However, early diagnosis is currently ...

Objectives: Lesion detection and characterization in multiple sclerosis (MS) are an essential part of its clinical diagnosis and an important research field. In this pilot study, we applied the recently introduced two inversion-contrast magnetization-prepa ...

In in vivo H-1 spectroscopy, the signal at 1.32 ppm is usually assigned to lactate. This resonance position is shared with threonine at physiological pH. The similarity of spectral patterns of lactate and threonine renders the separate measurement of eithe ...

Although numerous positron emission tomography (PET) studies with ((8) F-fluoro-deoxyglucose) FDG have reported quantitative results on cerebral glucose kinetics and consumption, there is a large variation between the absolute values found in the literatur ...

PURPOSE: Most existing methods for accelerated parallel imaging in MRI require additional data, which are used to derive information about the sensitivity profile of each radiofrequency (RF) channel. In this work, a method is presented to avoid the acquisi ...

Quantification of short-echo time proton magnetic resonance spectroscopy results in >18 metabolite concentrations (neurochemical profile). Their quantification accuracy depends on the assessment of the contribution of macromolecule (MM) resonances, previou ...

For most of the last forty years, the techniques of Dynamic Nuclear Polarization (DNP) have been confined to particle-physics laboratories building polarized targets, but recently it has been shown that samples similar to a solid target can be transformed ...

In vivo MRS is a non-invasive measurement technique used not only in humans, but also in animal models using high-field magnets. MRS enables the measurement of metabolite concentrations as well as metabolic rates and their modifications in healthy animals ...

Mood disorders (MD) are a major burden on society as their biology remains poorly understood, challenging both diagnosis and therapy. Among many observed biological dysfunctions, homeostatic dysregulation, such as metabolic syndrome (MeS), shows considerab ...

Energy metabolism supports both inhibitory and excitatory neurotransmission processes. This study investigated the specific contribution of astrocytic metabolism to γ-aminobutyric acid (GABA) synthesis and inhibitory GABAergic neurotransmission that remain ...

BACKGROUND: The heart relies on continuous energy production and imbalances herein impair cardiac function directly. The tricarboxylic acid (TCA) cycle is the primary means of energy generation in the healthy myocardium, but direct noninvasive quantificati ...

Functional magnetic resonance imaging (fMRI) measures activation-induced signal changes by means of the blood-oxygenation-level-depended (BOLD) contrast. Since signal changes are typically only 1-3%, the method is intrinsically sensitive to all signal inst ...

BACKGROUND: Oxidative stress and glutathione (GSH) metabolism dysregulation has been implicated in the pathophysiology of schizophrenia. GAG-trinucleotide repeat (TNR) polymorphisms in the glutamate-cysteine ligase catalytic gene (GCLC), the rate-limiting ...

Purpose: Simultaneous scalp electroencephalography and functional magnetic resonance imaging (EEG-fMRI) enable noninvasive assessment of brain function with high spatial and temporal resolution. However, at ultra-high field, the data quality of both modali ...

Rolf Gruetter

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Clinical Proton MR Spectroscopy in Central Nervous System Disorders

Steady-state brain glucose transport kinetics re-evaluated with a four-state conformational model

Assessment of metabolic fluxes in the mouse brain in vivo using (1)H-[(13)C] NMR spectroscopy at 14.1 Tesla

BOLD responses to trigeminal nerve stimulation

Technical and experimental features of Magnetic Resonance Spectroscopy of brain glycogen metabolism

Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients

An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker

MP2RAGE multiple sclerosis magnetic resonance imaging at 3 T

Editing through multiple bonds: Threonine detection

MRS glucose mapping and PET joining forces: Re-evaluation of the lumped constant in the rat brain under isoflurane anaesthesia

Parallel imaging with phase scrambling

Diffusion-Weighted Spectroscopy: A Novel Approach to Determine Macromolecule Resonances in Short-Echo Time H-1-MRS

Design and performance of a DNP prepolarizer coupled to a rodent MRI scanner

Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations

Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior

Glutamatergic and GABAergic energy metabolism measured in the rat brain by 13C NMR spectroscopy at 14.1 T

Direct noninvasive estimation of myocardial tricarboxylic acid cycle flux in vivo using hyperpolarized 13C magnetic resonance

Adaptive FID-navigators for respiration monitoring in multi-slice fMRI applications

Genetic Polymorphism Associated Prefrontal Glutathione and Its Coupling With Brain Glutamate and Peripheral Redox Status in Early Psychosis

Segmenting electroencephalography wires reduces radiofrequency shielding artifacts in simultaneous electroencephalography and functional magnetic resonance imaging at 7 T