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Carl Petersen

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Related publications (90)

Imaging the Dynamics of Neocortical Population Activity in Behaving and Freely Moving Mammals

The development of functional imaging techniques applicable to neuroscience and covering a wide range of spatial and temporal scales has greatly facilitated the exploration of the relationships between cognition, behaviour and electrical brain activity. Fo ...

Springer-Verlag Berlin2015

Cortical Sensorimotor Reverberations

Carl Petersen, Sylvain Crochet

In this issue of Neuron, Manita et al. (2015) report that reciprocal excitatory interactions between higher-order frontal motor cortex and primary sensorimotor cortex might play a key role in hindlimb sensory perception in mice. In this issue of Neuron, Ma ...

Cell Press2015

In Vivo Measurement of Cell-Type-Specific Synaptic Connectivity and Synaptic Transmission in Layer 2/3 Mouse Barrel Cortex

Carl Petersen, Aurélie Pala

Intracellular recordings of membrane potential in vitro have defined fundamental properties of synaptic communication. Much less is known about the properties of synaptic connectivity and synaptic transmission in vivo. Here, we combined single-cell opto-ge ...

Cell Press2015

Cell-Type-Specific Sensorimotor Processing in Striatal Projection Neurons during Goal-Directed Behavior

Carl Petersen, Sylvain Crochet, Tanya C Sippy, Damien Lapray

Goal-directed sensorimotor transformation drives important aspects of mammalian behavior. The striatum is thought to play a key role in reward-based learning and action selection, receiving glutamatergic sensorimotor signals and dopaminergic reward signals ...

Cell Press2015

Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation

Carl Petersen, Graham Knott, Natalya Korogod

Analysis of brain ultrastructure using electron microscopy typically relies on chemical fixation. However, this is known to cause significant tissue distortion including a reduction in the extracellular space. Cryo fixation is thought to give a truer repre ...

Elife Sciences Publications Ltd2015

Parallel pathways from motor and somatosensory cortex for controlling whisker movements in mice

Carl Petersen, Varun Sreenivasan

Mice can gather tactile sensory information by actively moving their whiskers to palpate objects in their immediate surroundings. Whisker sensory perception therefore requires integration of sensory and motor information, which occurs prominently in the ne ...

Wiley-Blackwell2015

Cell-type specific function of GABAergic neurons in layers 2 and 3 of mouse barrel cortex

Carl Petersen

GABAergic neurons are a minor fraction of the neocortical neuronal population, but they are highly diverse in their features. The GABAergic neurons can be divided into three largely non-overlapping groups, defined through the expression of ionotropic serot ...

Current Biology Ltd2014

From Perception to Action: A Spatiotemporal Cortical Map

Carl Petersen, Sylvain Crochet

Cell Press2014

Connection-type-specific biases make uniform random network models consistent with cortical recordings

Wulfram Gerstner, Carl Petersen, Michael Avermann, Christian Tomm, Tim Vogels

Uniform random sparse network architectures are ubiquitous in computational neuroscience, but the implicit hypothesis that they are a good representation of real neuronal networks has been met with skepticism. Here we used two experimental data sets, a stu ...

American Physiological Society2014

Cholinergic Signals in Mouse Barrel Cortex during Active Whisker Sensing

Carl Petersen, Sylvain Crochet, Yves Emile Alfred Kremer, Emmanuel Albert Eggermann

Internal brain states affect sensory perception, cognition, and learning. Many neocortical areas exhibit changes in the pattern and synchrony of neuronal activity during quiet versus active behaviors. Active behaviors are typically associated with desynchr ...

Elsevier2014

Cortical Control of Whisker Movement

Carl Petersen

Facial muscles drive whisker movements, which are important for active tactile sensory perception in mice and rats. These whisker muscles are innervated by cholinergic motor neurons located in the lateral facial nucleus. The whisker motor neurons receive s ...

Annual Reviews2014

Barrel cortex function

Carl Petersen, James Poulet

Neocortex, the neuronal structure at the base of the remarkable cognitive skills of mammals, is a layered sheet of neuronal tissue composed of juxtaposed and interconnected columns. A cortical column is considered the basic module of cortical processing pr ...

Pergamon-Elsevier Science Ltd2013

Membrane Potential Dynamics of Neocortical Projection Neurons Driving Target-Specific Signals

Carl Petersen, Egbert Welker, Aurélie Pala, Leticia Pedrido, Yves Emile Alfred Kremer, Takayuki Yamashita

Primary sensory cortex discriminates incoming sensory information and generates multiple processing streams toward other cortical areas. However, the underlying cellular mechanisms remain unknown. Here, by making whole-cell recordings in primary somatosens ...

Cell Press2013

Synaptic Computation and Sensory Processing in Neocortical Layer 2/3

Carl Petersen, Sylvain Crochet

Computations in neocortical circuits are predominantly driven by synaptic integration of excitatory glutamatergic and inhibitory GABAergic inputs. New optical, electrophysiological, and genetic methods allow detailed in vivo investigation of the superficia ...

Cell Press2013

Membrane potential correlates of sensory perception in mouse barrel cortex

Carl Petersen, Shankar Sachidhanandam, Yves Emile Alfred Kremer, Varun Sreenivasan, Alexandros Kyriakatos

Neocortical activity can evoke sensory percepts, but the cellular mechanisms remain poorly understood. We trained mice to detect single brief whisker stimuli and report perceived stimuli by licking to obtain a reward. Pharmacological inactivation and optog ...

Nature Publishing Group2013

Parameter extraction and classification of three cortical neuron types reveals two distinct adaptation mechanisms

Wulfram Gerstner, Skander Mensi, Carl Petersen, Christian Antonio Pozzorini, Michael Avermann, Richard Naud

Mensi S, Naud R, Pozzorini C, Avermann M, Petersen CCH, Gerstner W. Parameter extraction and classification of three cortical neuron types reveals two distinct adaptation mechanisms. J Neurophysiol 107: 1756-1775, 2012. First published December 7, 2011; do ...

American Physiological Society2012

Thalamic control of cortical states

Carl Petersen, Sylvain Crochet, James Poulet

We investigated the impact of thalamus on ongoing cortical activity in the awake, behaving mouse. We demonstrate that the desynchronized cortical state during active behavior is driven by a centrally generated increase in thalamic action potential firing, ...

Nature Publishing Group2012

Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex

Wulfram Gerstner, Carl Petersen, Céline Matéo, Michael Avermann, Christian Tomm

Avermann M, Tomm C, Mateo C, Gerstner W, Petersen CC. Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex. J Neurophysiol 107: 3116-3134, 2012. First published March 7, 2012; doi:10.1152/jn.00917.2011.-Synaptic interactio ...

American Physiological Society2012

Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex

Carl Petersen, Yves Emile Alfred Kremer

Neocortical GABAergic neurons have diverse molecular, structural and electrophysiological features, but the functional correlates of this diversity are largely unknown. We found unique membrane potential dynamics of somatostatin-expressing (SOM) neurons in ...

Nature Publishing Group2012

Synaptic Mechanisms Underlying Sparse Coding of Active Touch

Carl Petersen, Sylvain Crochet, James Poulet, Yves Emile Alfred Kremer

Sensory information is actively gathered by animals, but the synaptic mechanisms driving neuronal circuit function during active sensory processing are poorly understood. Here, we investigated the synaptically driven membrane potential dynamics during acti ...

2011

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