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We investigated the impact of thalamus on ongoing cortical activity in the awake, behaving mouse. We demonstrate that the desynchronized cortical state during active behavior is driven by a centrally generated increase in thalamic action potential firing, which can also be mimicked by optogenetic stimulation of the thalamus. The thalamus therefore is key in controlling cortical states.
Friedhelm Christoph Hummel, Maximilian Jonas Wessel, Takuya Morishita, Traian Popa, Elena Beanato, Pierre Theopistos Vassiliadis, Fabienne Windel
Dimitri Nestor Alice Van De Ville, Farnaz Delavari