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Carl Petersen

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Related publications (90)

Cortical circuits for transforming whisker sensation into goal-directed licking

Carl Petersen, Sylvain Crochet, Georgios Foustoukos, Vahid Esmaeili, Keita Tamura, Anastasiia Oryshchuk

Animals can learn to use sensory stimuli to generate motor actions in order to obtain rewards. However, the precise neuronal circuits driving learning and execution of a specific goal-directed sensory-to-motor transformation remain to be elucidated. Here, ...

2020

Pathway-, layer- and cell-type-specific thalamic input to mouse barrel cortex

Carl Petersen, Berat Semihcan Sermet, Johannes Maria Mayrhofer

Mouse primary somatosensory barrel cortex (wS1) processes whisker sensory information, receiving input from two distinct thalamic nuclei. The first-order ventral posterior medial (VPM) somatosensory thalamic nucleus most densely innervates layer 4 (L4) bar ...

2019

Sensorimotor processing in the rodent barrel cortex

Carl Petersen

Tactile sensory information from facial whiskers provides nocturnal tunnel-dwelling rodents, including mice and rats, with important spatial and textural information about their immediate surroundings. Whiskers are moved back and forth to scan the environm ...

NATURE PUBLISHING GROUP2019

Neural Circuits for Goal-Directed Sensorimotor Transformations

Carl Petersen, Sylvain Crochet, Seung-Hee Lee

Precisely wired neuronal circuits process sensory information in a learning- and context-dependent manner in order to govern behavior. Simple sensory decision-making tasks in rodents are now beginning to reveal the contributions of distinct cell types and ...

ELSEVIER SCIENCE LONDON2019

Distinct Contributions of Whisker Sensory Cortex and Tongue-Jaw Motor Cortex in a Goal-Directed Sensorimotor Transformation

Sami El-Boustani, Carl Petersen, Matthieu Pierre Auffret, Johannes Maria Mayrhofer, Georgios Foustoukos, Keita Tamura

The neural circuits underlying goal-directed sensorimotor transformations in the mammalian brain are incompletely understood. Here, we compared the role of primary tongue-jaw motor cortex (tjM1) and primary whisker sensory cortex (wS1) in head-restrained m ...

2019

Diverse Long-Range Axonal Projections of Excitatory Layer 2/3 Neurons in Mouse Barrel Cortex

Carl Petersen, Aurélie Pala, Sylvain Crochet, Takayuki Yamashita, Katia Galan

2018

OPTOGENETIC STIMULATION OF CORTEX TO MAP EVOKED WHISKER MOVEMENTS IN AWAKE HEAD-RESTRAINED MICE

Carl Petersen, Matthieu Pierre Auffret

2018

Reward-Based Learning Drives Rapid Sensory Signals in Medial Prefrontal Cortex and Dorsal Hippocampus Necessary for Goal-Directed Behavior

Carl Petersen, Sylvain Crochet, Pierre François Philippe Le Merre, Eloïse Ludivine Charrière, Katia Galan, Vahid Esmaeili

2018

State-dependent cell-type-specific membrane potential dynamics and unitary synaptic inputs in awake mice

Carl Petersen, Aurélie Pala

2018

Whole-Cell Recording of Neuronal Membrane Potential during Behavior

Carl Petersen

Neuronal membrane potential is of fundamental importance for the mechanistic understanding of brain function. This review discusses progress in whole-cell patch-clamp recordings for low-noise measurement of neuronal membrane potential in awake behaving ani ...

Cell Press2017

Parallel pathways from whisker and visual sensory cortices to distinct frontal regions of mouse neocortex

Carl Petersen, Céline Matéo, Varun Sreenivasan, Alexandros Kyriakatos

The spatial organization of mouse frontal cortex is poorly understood. Here, we used voltage-sensitive dye to image electrical activity in the dorsal cortex of awake head-restrained mice. Whisker-deflection evoked the earliest sensory response in a localiz ...

SPIE-Intl Soc Optical Eng2017

Voltage-sensitive dye imaging of mouse neocortex during a whisker detection task

Carl Petersen, Matthieu Pierre Auffret, Alexandros Kyriakatos, Alessandro Motta, Vijay Sadashivaiah, Yifei Zhang

Sensorimotor processing occurs in a highly distributed manner in the mammalian neocortex. The spatiotemporal dynamics of electrical activity in the dorsal mouse neocortex can be imaged using voltage-sensitive dyes (VSDs) with near-millisecond temporal reso ...

SPIE-Intl Soc Optical Eng2017

Pioneers in Neurophotonics: Special Section Honoring Professor Amiram Grinvald

Carl Petersen

Spie-Soc Photo-Optical Instrumentation Engineers2017

Layer-Dependent Short-Term Synaptic Plasticity Between Excitatory Neurons in the C2 Barrel Column of Mouse Primary Somatosensory Cortex

Carl Petersen, Sandrine Lefort

Neurons process information through spatiotemporal integration of synaptic input. Synaptic transmission between any given pair of neurons is typically a dynamic process with presynaptic action potentials (APs) evoking depressing or facilitating postsynapti ...

Oxford Univ Press Inc2017

Parvalbumin-Expressing GABAergic Neurons in Mouse Barrel Cortex Contribute to Gating a Goal-Directed Sensorimotor Transformation

Carl Petersen, Shankar Sachidhanandam, Berat Semihcan Sermet

Sensory processing in neocortex is primarily driven by glutamatergic excitation, which is counterbalanced by GABAergic inhibition, mediated by a diversity of largely local inhibitory interneurons. Here, we trained mice to lick a reward spout in response to ...

Elsevier2016

Movement Initiation Signals in Mouse Whisker Motor Cortex

Carl Petersen, Sylvain Crochet, Varun Sreenivasan, Taro Kiritani, Katia Galan, Vahid Esmaeili

Frontal cortex plays a central role in the control of voluntary movements, which are typically guided by sensory input. Here, we investigate the function of mouse whisker primary motor cortex (wM1), a frontal region defined by dense innervation from whiske ...

Cell Press2016

Target-specific membrane potential dynamics of neocortical projection neurons during goal-directed behavior

Carl Petersen, Takayuki Yamashita

Goal-directed behavior involves distributed neuronal circuits in the mammalian brain, including diverse regions of neocortex. However, the cellular basis of long-range cortico-cortical signaling during goal-directed behavior is poorly understood. Here, we ...

Elife Sciences Publications Ltd2016

Inhibition Patterns the Whisking Rhythm

Carl Petersen, Varun Sreenivasan

In this issue of Neuron, Deschenes et al. (2016) propose that rhythmic inhibition of whisker motor neurons is a key pattern generator underlying exploratory whisking. The inhibitory premotor neurons located in the brain-stem reticular formation are synchro ...

Cell Press2016

Whisking-Related Changes in Neuronal Firing and Membrane Potential Dynamics in the Somatosensory Thalamus of Awake Mice

Carl Petersen

The thalamus transmits sensory information to the neocortex and receives neocortical, subcortical, and neuromodulatory inputs. Despite its obvious importance, surprisingly little is known about thalamic function in awake animals. Here, using intracellular ...

Elsevier2015

Optogenetic Dissection of the Basal Forebrain Neuromodulatory Control of Cortical Activation, Plasticity, and Cognition

Carl Petersen

The basal forebrain (BF) houses major ascending projections to the entire neocortex that have long been implicated in arousal, learning, and attention. The disruption of the BF has been linked with major neurological disorders, such as coma and Alzheimer's ...

Soc Neuroscience2015

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