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Carl Petersen

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Related publications (90)

In Vivo Optogenetic Stimulation of Neocortical Excitatory Neurons Drives Brain-State-Dependent Inhibition

Carl Petersen, Céline Matéo, Michael Avermann

Background: Synaptic interactions between excitatory and inhibitory neocortical neurons are important for mammalian sensory perception. Synaptic transmission between identified neurons within neocortical microcircuits has mainly been studied in brain slice ...

Elsevier2011

Motor control by sensory cortex

Carl Petersen, Rachel Aronoff, Fred Marbach, Céline Matéo, Ferenc Mátyás, Varun Sreenivasan, Catherine Wacongne

Classical studies of mammalian movement control define a prominent role for the primary motor cortex. Investigating the mouse whisker system, we found an additional and equally direct pathway for cortical motor control driven by the primary somatosensory c ...

American Association for the Advancement of Science2010

Long-range connectivity of mouse primary somatosensory barrel cortex

Bernard Schneider, Carl Petersen, Rachel Aronoff, Céline Matéo, Ferenc Mátyás

The primary somatosensory barrel cortex processes tactile vibrissae information, allowing rodents to actively perceive spatial and textural features of their immediate surroundings. Each whisker on the snout is individually represented in the neocortex by ...

Wiley-Blackwell2010

Membrane potential dynamics of GABAergic neurons in the barrel cortex of behaving mice

Carl Petersen, Michael Avermann, Ferenc Mátyás

Computations in cortical circuits are mediated by synaptic interactions between excitatory and inhibitory neurons, and yet we know little about their activity in awake animals. Here, through single and dual whole-cell recordings combined with two-photon mi ...

Elsevier2010

BOLD responses to trigeminal nerve stimulation

Carl Petersen, Rolf Gruetter, Nathalie Just

The current study investigates a new model of barrel cortex activation using stimulation of the infraorbital branch of the trigeminal nerve. A robust and reproducible activation of the rat barrel cortex was obtained following trigeminal nerve stimulation. ...

2010

Fast Fluorescence Dynamics in Non-ratiometric Calcium Indicators

Cristiano Niclass, Marek Gersbach, Dmitri Boiko, Edoardo Charbon, Carl Petersen

2009

The Excitatory Neuronal Network of the C2 Barrel Column in Mouse Primary Somatosensory Cortex

Juan-Carlos Sarria, Carl Petersen, Sandrine Lefort, Christian Tomm

Local microcircuits within neocortical columns form key determinants of sensory processing. Here, we investigate the excitatory synaptic neuronal network of an anatomically defined cortical column, the C2 barrel column of mouse primary somatosensory cortex ...

2009

Genetic determinants of barrel cortex map formation

Carl Petersen

Wiley-Blackwell2009

Synaptic Mechanisms Of Sensory Perception

Carl Petersen

2009

Genetic manipulation, whole-cell recordings and functional imaging of the sensorimotor cortex of behaving mice

Carl Petersen

Sensory processing, sensorimotor integration and motor control are amongst the most basic functions of the brain and yet our understanding of how the underlying neuronal networks operate and contribute to behaviour is very limited. The relative simplicity ...

2009

Extracting non-linear integrate-and-fire models from experimental data using dynamic I – V curves

Wulfram Gerstner, Laurent Badel, Carl Petersen, Sandrine Lefort, Thomas Berger

The dynamic I–V curve method was recently introduced for the efficient experimental generation of reduced neuron models. The method extracts the response properties of a neuron while it is subject to a naturalistic stimulus that mimics in vivo-like fluctua ...

Springer Verlag2008

Dynamic I-V curves are reliable predictors of naturalistic pyramidal-neuron voltage traces

Wulfram Gerstner, Laurent Badel, Carl Petersen, Sandrine Lefort, Romain Brette

Neuronal response properties are typically probed by intracellular measurements of current-voltage (I-V) relationships during application of current or voltage steps. Here we demonstrate the measurement of a novel I-V curve measured while the neuron exhibi ...

American Physiological Society2008

Internal brain state regulates membrane potential synchrony in barrel cortex of behaving mice

Carl Petersen, James Poulet

Internal brain states form key determinants for sensory perception, sensorimotor coordination and learning. A prominent reflection of different brain states in the mammalian central nervous system is the presence of distinct patterns of cortical synchrony, ...

Nature Publishing Group2008

Layer, column and cell-type specific genetic manipulation in mouse barrel cortex

Carl Petersen, Rachel Aronoff

Sensory information is processed in distributed neuronal networks connected by intricate synaptic circuits. Studies of the rodent brain can provide insight into synaptic mechanisms of sensory perception and associative learning. In particular, the mouse wh ...

Frontiers Research Foundation2008

Sensory Systems

Carl Petersen

Blackwell2007

Time-correlated Two-photon Fluorescence Imaging with Arrays of Solid-state Single Photon Detector

Cristiano Niclass, Marek Gersbach, Dmitri Boiko, Edoardo Charbon, Carl Petersen

This paper reports on our progress in developing two-photon fluorescence lifetime imaging microscopy (FLIM) based on time-correlated single-photon counting (TCSPC). The core of the system is a 2D array of solid-state single-photon avalanche diodes (SPADs) ...

2007

Combined voltage and calcium epifluorescence imaging in vitro and in vivo reveals subthreshold and suprathreshold dynamics of mouse barrel cortex

Carl Petersen, Sandrine Lefort, Sylvain Crochet, Thomas Berger

Cortical dynamics can be imaged at high spatiotemporal resolution with voltage-sensitive dyes (VSDs) and calcium-sensitive dyes (CaSDs). We combined these two imaging techniques using epifluorescence optics together with whole cell recordings to measure th ...

2007

Higher Nervous Functions

Carl Petersen

Blackwell2007

Layer- and column-specific knockout of NMDA receptors in pyramidal neurons of the mouse barrel cortex

Carl Petersen, Rachel Aronoff

Viral vectors injected into the mouse brain offer the possibility for localized genetic modifications in a highly controlled manner. Lentivector injection into mouse neocortex transduces cells within a diameter of approximately 200mum, which closely matche ...

Frontiers Research Foundation2007

The functional organization of the barrel cortex

Carl Petersen

The tactile somatosensory pathway from whisker to cortex in rodents provides a well-defined system for exploring the link between molecular mechanisms, synaptic circuits, and behavior. The primary somatosensory cortex has an exquisite somatotopic map where ...

2007

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