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Giovanni Dietler

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Related publications (156)

Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6

Giovanni Dietler, Hilal Lashuel, Anass Chiki, Annalisa Ansaloni, Francesco Simone Ruggeri, Ritwik Burai, Sophie Vieweg, Sean Michael Deguire, Urszula Beata Cendrowska

Herein, we used protein semisynthesis to investigate, for the first time, the effect of lysine acetylation and phosphorylation, as well as the crosstalk between these modifications on the structure and aggregation of mutant huntingtin exon1 (Httex1). Our r ...

Wiley-Blackwell2017

Nanomechanics of multidomain neuronal cell adhesion protein contactin revealed by single molecule AFM and SMD

Andrzej Kulik, Giovanni Dietler, Karolina Anna Mikulska Ruminska

Contactin-4 (CNTN4) is a complex cell adhesion molecule (CAM) localized at neuronal membranes, playing a key role in maintaining the mechanical integrity and signaling properties of the synapse. CNTN4 consists of six immunoglobulin C2 type (IgC2) domains a ...

Springer Nature2017

Spatial organization of DNA sequences directs the assembly of bacterial chromatin by a nucleoid-associated protein

Giovanni Dietler, Aleksandre Japaridze, Sylvain Renevey

Structural differentiation of bacterial chromatin depends on cooperative binding of abundant nucleoid-associated proteins at numerous genomic DNA sites and stabilization of distinct long-range nucleoprotein structures. Histone-like nucleoid-structuring pro ...

American Society for Biochemistry & Molecular Biology (ASBMB)2017

Hyperplectonemes: A Higher Order Compact and Dynamic DNA Self-Organization

Giovanni Dietler, Paolo De Los Rios, Fabrizio Benedetti, Giovanni Longo, Aleksandre Japaridze

Bacterial chromosome has a compact structure that dynamically changes its shape in response to bacterial growth rate and growth phase. Determining how chromatin remains accessible to DNA binding proteins, and transcription machinery is crucial to understan ...

American Chemical Society2017

High-Q surface modes in photonic crystal/iron garnet film heterostructures for sensor applications

Giovanni Dietler, Serguei Sekatski, Pavel Kapralov

A novel type of a plasmonic sensor based on a magnetophotonic plasmonic heterostructure with an ultrahigh-Q resonance is considered. A magnetoplasmonic resonance with an angular width of 0.06A degrees, which corresponds to a Q factor of 700 and is a record ...

Springer Verlag2017

Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection

Giovanni Dietler, Hilal Lashuel, Francesco Simone Ruggeri, Hatice Altug, Dordaneh Etezadi, John Blaine Warner IV

Plasmonic nanoantennas offer new applications in mid-infrared (mid-IR) absorption spectroscopy with ultrasensitive detection of structural signatures of biomolecules, such as proteins, due to their strong resonant near-fields. The amide I fingerprint of a ...

Springer Nature2017

Nanomechanical sensor applied to blood culture pellets: a fast approach to determine the antibiotic susceptibility against agents of bloodstream infections

Giovanni Dietler, Sandor Kasas, Giovanni Longo, Petar Stupar

Objectives: The management of bloodstream infection, a life-threatening disease, largely relies on early detection of infecting microorganisms and accurate determination of their antibiotic susceptibility to reduce both mortality and morbidity. Recently we ...

2017

Mitochondrial activity detected by cantilever based sensor

Giovanni Dietler, Sandor Kasas, Petar Stupar, Wojciech Chomicki

Our team recently demonstrated that cantilever based devices can detect signature of life in a chemistry independent manner. In this technique, the organism of interest is attached onto a classical AFM cantilever. If alive, it induces nanometre scale oscil ...

Copernicus GmbH2017

Spatial confinement induces hairpins in nicked circular DNA

Giovanni Dietler, Aleksandre Japaridze, Enzo Orlandini

In living cells, DNA is highly confined in space with the help of condensing agents, DNA binding proteins and high levels of supercoiling. Due to challenges associated with experimentally studying DNA under confinement, little is known about the impact of ...

Oxford University Press (OUP)2017

Amyloid Single Cell Cytotoxicity Assays by Nanomotion Detection

Giovanni Dietler, Sandor Kasas, Hilal Lashuel, Giovanni Longo, Francesco Simone Ruggeri, Anne-Laure Mahul Mellier

Cells are extremely complex systems able to modify actively their metabolism and behaviour in response to environmental conditions and stimuli, such as pathogenic agents or drugs. The comprehension of these responses is central to understand the molecular ...

Springer Nature2017

MechStiff: A New Tool for Evaluating Stress-Induced Dynamics and Application to Cell Adhesion Proteins

Andrzej Kulik, Giovanni Dietler, Karolina Anna Mikulska Ruminska

Cell Press2017

A Robust Actin Filaments Image Analysis Framework

Giovanni Dietler, Sandor Kasas

The cytoskeleton is a highly dynamical protein network that plays a central role in numerous cellular physiological processes, and is traditionally divided into three components according to its chemical composition, i.e. actin, tubulin and intermediate fi ...

Public Library of Science2016

Can Dissipative Properties of Single Molecules Be Extracted from a Force Spectroscopy Experiment?

Andrzej Kulik, Giovanni Dietler, Serguei Sekatski, Dmitry Klinov, Fabrizio Benedetti

We performed dynamic force spectroscopy of single dextran and titin 127 molecules using small-amplitude and low-frequency (40-240 Hz) dithering of an atomic force microscope tip excited by a sine wave voltage fed onto the tip-carrying piezo. We show that f ...

Elsevier2016

Nanoscale studies link amyloid maturity with polyglutamine diseases onset

Giovanni Dietler, Hilal Lashuel, Giovanni Longo, Francesco Simone Ruggeri, Urszula Beata Cendrowska

The presence of expanded poly-glutamine (polyQ) repeats in proteins is directly linked to the pathogenesis of several neurodegenerative diseases, including Huntington's disease. However, the molecular and structural basis underlying the increased toxicity ...

Nature Research2016

A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates

Giovanni Dietler, Francesco Simone Ruggeri

A wide consensus based on robust experimental evidence indicates pyroglutamylated amyloid-beta isoform (A beta pE3-42) as one of the most neurotoxic peptides involved in the onset of Alzheimer's disease. Furthermore, A beta pE3-42 co-oligomerized with exce ...

Elsevier2016

Magneto-optical plasmonic heterostructure with ultranarrow resonance for sensing applications

Giovanni Dietler, Serguei Sekatski, Pavel Kapralov

Currently, sensors invade into our everyday life to bring higher life standards, excellent medical diagnostic and efficient security. Plasmonic biosensors demonstrate an outstanding performance ranking themselves among best candidates for different applica ...

Nature Research2016

Preparation of Well-Defined DNA Samples for Reproducible Nanospectroscopic Measurements

Giovanni Dietler, Aleksandre Japaridze, Ewelina Wioletta Lipiec

Wiley-Blackwell2016

Micro- and nanoscale hierarchical structure of core-shell protein microgels

Raffaele Mezzenga, Giovanni Dietler, Francesco Simone Ruggeri

Protein nanofibrils were first discovered in the context of misfolding and neurodegenerative diseases but have recently been found in naturally occurring functional materials including algal adhesives, bacterial coatings, and even mammalian melanosomes. Th ...

Royal Society of Chemistry2016

The persistence length of adsorbed dendronized polymers (vol 8, pg 13498, 2016)

Giovanni Dietler, Plinio Maroni, Michal Borkovec, Andrey Mikhaylov

Royal Society of Chemistry2016

The persistence length of adsorbed dendronized polymers

Giovanni Dietler, Plinio Maroni, Michal Borkovec, Andrey Mikhaylov

The persistence length of cationic dendronized polymers adsorbed onto oppositely charged substrates was studied by atomic force microscopy (AFM) and quantitative image analysis. One can find that a decrease in the ionic strength leads to an increase of the ...

Royal Society of Chemistry2016

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