Publication

Time-Lapse AFM Imaging of DNA Conformational Changes Induced by Daunorubicin

Giovanni Dietler, Sandor Kasas, Giovanni Longo, Livan Bladimir Alonso Sarduy
2013
Journal Articles

Abstract

Cancer is a major health issue that absorbs the attention of a large part of the biomedical research. Intercalating agents bind to DNA molecules and can inhibit their synthesis and transcription; thus, they are increasingly used as drugs to fight cancer. In this work, we show how atomic force microscopy in liquid can characterize, through time-lapse imaging, the dynamical influence of intercalating agents on the supercoiling of DNA, improving our understanding of the drug's effect.

Official source

https://infoscience.epfl.ch/entities/publication/f161411a-e062-4656-be43-e9ac819bd2f5

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Time-Lapse AFM Imaging of DNA Conformational Changes Induced by Daunorubicin

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