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Martinus Gijs

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Related publications (370)

An automated microfluidic platform for reversible immobilization and imaging of C. elegans

Thomas Lehnert, Martinus Gijs, Johan Auwerx, Matteo Cornaglia, Marie-Pierre Meurville, Laurent Mouchiroud, Govindan Narayanan Krishnamani

2014

Delayed voltammetric with respect to amperometric electrochemical detection of concentration changes in microchannels

Martinus Gijs, Raphaël Etienne Jean Trouillon

The time response of an electrode incorporated into a fluidic channel to variations in analyte concentration of the outer-sphere redox probe ferrocenemethanol was investigated both for amperometry (AMP) and cyclic voltammetry (CV). The experimental data sh ...

Royal Society of Chemistry2014

Microfluidic chip for monitoring Ca2+ transport through a confluent layer of intestinal cells

Martinus Gijs, Paolo Silacci, Guy Vergères, Hüseyin Cumhur Tekin, Josias Basil Wacker, Christine Ruffert

The absorption of dietary calcium through the intestinal barrier is essential for maintaining health in general and especially of the bone system. We propose a microfluidic model that studies free calcium (Ca2+) transport through a confluent monolayer of C ...

Royal Soc Chemistry2014

An automated microfluidic platform for long-term high-resolution imaging of C. elegans

Thomas Lehnert, Martinus Gijs, Johan Auwerx, Matteo Cornaglia, Marie-Pierre Meurville, Laurent Mouchiroud, Govindan Narayanan Krishnamani

We describe a microfluidic platform for the automated culture, treatment and long-term highresolution imaging of Caenorhabditis elegans nematodes under normal physiological conditions. Our device features: (i) a microfluidic design tailored for the isolati ...

2014

Programming and use of Parylene C fluorescence as a quantitative on-chip reference

Martinus Gijs, Ata Tuna Ciftlik, Diego Gabriel Dupouy, Joan Teixidor

A large number of lab-on-a-chip applications use fluorescence for quantifying biological entities. In such applications, incorporation of a stable on-chip fluorescent reference source would be highly desirable in order to compensate for instrumental parame ...

Royal Soc Chemistry2014

Large spherical assemblies of oxide nanoparticles

Martinus Gijs, Virendra Kumar Parashar, Josias Basil Wacker

2014

Fabrication of a high aspect ratio (HAR) micropillar filter for a magnetic bead-based immunoassay

Martinus Gijs, Christine Ruffert

A microfluidic chip has been realized for investigating immune cell (U937) activation with lipopolysaccharide (LPS) and subsequent pro-inflammatory cytokine (Interleukin-6, IL-6) detection (Ruffert et al. Proc. EMBL Conference Microfluidics 2012a, p 184; P ...

Springer2014

Super-Resolution Biological Microscopy Using Virtual Imaging by a Microsphere Nanoscope

Martinus Gijs, Johan Auwerx, Norman Lionel Moullan, Hui Yang

Wiley-Blackwell2014

Impact of milk processing on the generation of peptides during digestion

Martinus Gijs, Guy Vergères, Flurina Schwander, Reto Portmann

Milk processing may induce changes in dairy product composition and influence digestibility and nutrient bioavailability. Differences in protein degradation and peptide generation were studied for beta-lactoglobulin and alpha(S1)-casein from commercially a ...

Elsevier Sci Ltd2014

Voltammetric electrochemical detection of concentration changes in a microfluidic chip is delayed in comparison to amperometry

Martinus Gijs, Raphaël Etienne Jean Trouillon

2014

Fabrication of Biocompatible Monolithic Microchannels with High Pressure-Resistance Using Direct Polymerization of PEG-Modified PMMA

Martinus Gijs, Ata Tuna Ciftlik, Elena Bianchi

Withstanding high pressures in polymeric microchannels is an important requirement for many biological applications. Here, a simple direct polymerization through a polyester photomask is applied to obtain monolithic polyethylene glycol (PEG)-modified poly( ...

Wiley-Blackwell2014

Self-assembled melamine microlens arrays for immunofluorescence enhancement

Abdeljalil Sayah, Martinus Gijs, Hüseyin Cumhur Tekin, Hui Yang

Self-assembled dielectric microlenses are used for focusing of the fluorescent signal emitted from a surface-based immunoassay, performed on silane micropatterns as assay substrates, to enhance the detection signal. In our model system, a fluorescent immun ...

2013

Fine-tuning of magnetic and microfluidic viscous forces for specific magnetic bead-based immunocomplex formation

Thomas Lehnert, Martinus Gijs, Hüseyin Cumhur Tekin, Matteo Cornaglia

We investigate the working principle of a novel type of microfluidic sandwich immunoassay, as used for the detection of biomarkers. The heterogeneous assay is based on the specific interactions between an array of functionalized superparamagnetic beads and ...

American Institute of Physics2013

Characterization of short incubation time effects on chromogen signal obtained by HER2-expressing breast carcinomas using microfluidic immunohistochemistry

Martinus Gijs, Ata Tuna Ciftlik, Hans-Anton Lehr

2013

Polymer-based flexible capacitive sensor for three-axial force measurements

Martinus Gijs, Jagoda Anna Dobrzynska

We have developed a flexible-substrate-based three-axial force sensor, composed of finger-shaped electrode capacitors, whose operation is based on the measurement of a capacitance change induced upon applying a three-axial load. The electrode design suppor ...

Institute of Physics2013

Ultrasensitive protein detection: a case for microfluidic magnetic bead-based assays

Martinus Gijs, Hüseyin Cumhur Tekin

Royal Society of Chemistry2013

Microfluidic processor allows rapid HER2 immunohistochemistry of breast carcinomas and significantly reduces ambiguous (2+) read-outs

Martinus Gijs, Ata Tuna Ciftlik, Hans-Anton Lehr

Biomarker analysis is playing an essential role in cancer diagnosis, prognosis, and prediction. Quantitative assessment of immunohistochemical biomarker expression on tumor tissues is of clinical relevance when deciding targeted treatments for cancer patie ...

National Academy of Sciences2013

Microtextured Substrates and Microparticles Used as in Situ Lenses for On-Chip Immunofluorescence Amplification

Martinus Gijs, Hui Yang

We propose a concept for enhancing the fluorescent detection signal of on-chip immunoassays by using three-dimensional 3 and 8 mu m size microtextured structures as substrates for the assay, which allows exploitation of a large number of fluorophores withi ...

Amer Chemical Soc2013

Programmable parylene-C bonding layer fluorescence for storing information on microfluidic chips

Martinus Gijs, Ata Tuna Ciftlik, Diego Gabriel Dupouy

We demonstrate data storage on glass/silicon microfluidic devices fabricated using parylene-C as a bonding layer. In particular, we report intermediate parylene-C bonding layer fluorescence (iPBLF) and its use as an on-chip medium for data storage by dynam ...

Royal Society of Chemistry2013

Attomolar protein detection using a magnetic bead surface coverage assay

Martinus Gijs, Hüseyin Cumhur Tekin, Matteo Cornaglia

We demonstrate a microfluidic method for ultra-sensitive protein detection in serum. First, ‘large’ (2.8 μm) antibody-functionalized magnetic beads specifically capture antigen from a serum matrix under active microfluidic mixing. Subsequently, the large b ...

Royal Society of Chemistry2013

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